Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile

Vrieling, Frank; Ronacher, Katharina; Kleynhans, Léanie; Akker, Erik B. van den; Walzl, Gerhard; Ottenhoff, Tom H. M.; Joosten, Simone A.

doi:10.1016/j.ebiom.2018.05.011

Cited by 47 publications

(62 citation statements)

References 52 publications

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“…In our study we observed that the HDL level of DM and TB patients was at 34.17 mg/dl, the baseline HDL level of DM free TB patients was at 43.49 mg/dl. The nding was in line with the nding in Netherland [41], suggesting high malnutrition burdens in the study area [42].…”

Section: Discussionsupporting

confidence: 87%

Nexus Between Tuberculosis and Diabetic Mellitus, A Prospective Cohort Study.

Feleke

Kassahun

et al. 2020

Preprint

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Background: This work aimed to describe the clinical presentation of TB in patient with DM, to determine the effects of DM on TB treatment outcomes, to identify the effects of TB on glycemic control, and to describe the lipid profile of TB and DM patients. Methods: This prospective cohort study design was conducted. The data were collected from September 2018 to June 2020 using patient interviews, examining the patients, chart review, and collecting blood samples. Binary logistic regression was used to identify the determinants of TB treatment outcomes in the context of DM. Kaplan Meier survival curve was used to see the effects of DM on TB clinical response. Linear regression was used to identify the determinants of the HbA1c level during TB infection. Results: A total of 1092 study participants were included giving for the response rate at 93.81 %. Good TB treatment outcome was observed in 72.5 % of the patients [95 % CI: 69 % - 76 %]. The odds of good TB treatment outcomes were at 75 % lower in the presence of DM (AOR 0.25 [95 % CI: 0.08 – 0.73]). The median time of clinical response in TB and DM patients was 45 days interquartile range (IQR) of 8 days; the median time of clinical response in DM free TB patients was 9 days [IQR 2 days]. TB increased the HbA1c level of DM patients by 1.22 % (B 1.22 [95% CI: 1.11 – 1.34]). In six months period, 60 % of TB and DM patients had got 3 episodes of acute complications. Conclusion: DM significantly decreases the favorable treatment outcome of DOTS. TB predisposed DM patients for bad glycemic control and increased episodes of acute DM complications.

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Section: Discussionsupporting

confidence: 87%

Nexus Between Tuberculosis and Diabetic Mellitus, A Prospective Cohort Study.

Feleke

Kassahun

et al. 2020

Preprint

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“…An increased fasting serum TG concentration has been associated with coronary artery disease, increased mortality risk in coronary heart disease (CHD) patients, and an increased risk for developing both CHD and ischemic heart disease . Next to this, higher VLDL lipoprotein concentrations have been associated with ischemic heart disease risk, and higher levels of VLDL‐TG have been observed in type 2 diabetes mellitus patients . Thus, the effects of the MED diet, for example, the lowering of total VLDL‐TG, and serum TG concentration, may indicate a potential additional beneficial effect on cardiovascular risk on top of the effect of the MUFA content.…”

Section: Discussionmentioning

confidence: 99%

Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome

Michielsen

Hangelbroek

Feskens

et al. 2019

Molecular Nutrition Food Res

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Scope The Mediterranean (MED) diet has been associated with a decreased risk of cardiovascular diseases. It is unclear whether this health effect can be mainly contributed to high intakes of monounsaturated fatty acids (MUFA), characteristic for the MED diet, or whether other components of a MED diet also play an important role. Methods and Results A randomized fully controlled parallel trial is performed to examine the effects of the consumption of a saturated fatty acid rich diet, a MUFA‐rich diet, or a MED diet for 8 weeks on metabolite profiles, in 47 subjects at risk of the metabolic syndrome. A total of 162 serum metabolites are assessed before and after the intervention by using a targeted NMR platform. Fifty‐two metabolites are changed during the intervention (false discovery rate [FDR] p < 0.05). Both the MUFA and MED diet decrease exactly the same fractions of LDL, including particle number, lipid, phospholipid, and free cholesterol fraction (FDR p < 0.05). The MED diet additionally decreases the larger subclasses of very‐low‐density lipoprotein (VLDL), related VLDL fractions, VLDL‐triglycerides, and serum‐triglycerides (FDR p < 0.05). Conclusion The findings clearly demonstrate that the MUFA component is responsible for reducing LDL subclasses and fractions, and therefore causes an antiatherogenic lipid profile. Interestingly, consumption of the other components in the MED diet show additional health effects.

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“…1B) that was shown to be increased in patients in the study of Weiner et al 3 and Vrieling et al 13 . However, in a study of a TB patient cohort from South Africa, also a decreased level of phenylalanine was reported compared to the control group 30 .…”

Section: Metabolite Profiles Of Tb Patients Measured By Mass Spectrommentioning

confidence: 96%

Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae

Ding

Raterink

Marín-Juez

et al. 2020

Sci Rep

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tuberculosis is a highly infectious and potentially fatal disease accompanied by wasting symptoms, which cause severe metabolic changes in infected people. in this study we have compared the effect of mycobacteria infection on the level of metabolites in blood of humans and mice and whole zebrafish larvae using one highly standardized mass spectrometry pipeline, ensuring technical comparability of the results. Quantification of a range of circulating small amines showed that the levels of the majority of these compounds were significantly decreased in all three groups of infected organisms. Ten of these metabolites were common between the three different organisms comprising: methionine, asparagine, cysteine, threonine, serine, tryptophan, leucine, citrulline, ethanolamine and phenylalanine. The metabolomic changes of zebrafish larvae after infection were confirmed by nuclear magnetic resonance spectroscopy. Our study identified common biomarkers for tuberculosis disease in humans, mice and zebrafish, showing across species conservation of metabolic reprogramming processes as a result of disease. Apparently, the mechanisms underlying these processes are independent of environmental, developmental and vertebrate evolutionary factors. The zebrafish larval model is highly suited to further investigate the mechanism of metabolic reprogramming and the connection with wasting syndrome due to infection by mycobacteria. Infection with Mycobacterium tuberculosis (Mtb) can result in tuberculosis (TB) that currently is newly affecting over 10 million people per year and leading to 1.6 million deaths annually 1. However, the majority of people that have been infected with Mtb, estimated to be in the order of 2 billion, do not experience any symptoms in the presence of positive immunological (blood or skin) test results. In patients diagnosed with TB, the disease is uniformly characterized by a metabolic wasting syndrome that leads to heavy weight loss that concurs with a strong reduction of muscle mass. TB has therefore historically earned the name of "consumption". Novel tools for control of TB should include not only better treatments, including attention to the deleterious effects of wasting syndrome, but also needs to include cost-effective assays for robust and sensitive diagnosis of TB 2. Recent metabolomics studies have identified valuable diagnostic metabolic blood markers that can discriminate TB patients from healthy individuals 3-13. This appeared to be applicable to very different population groups, ranging from trans-Africa, China, Georgia, and Indonesia, and therefore highlighting that blood metabolites are robust and validating biomarkers for TB progression. These studies used mostly mass spectrometry (MS) and

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Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile

Cited by 47 publications

References 52 publications

Nexus Between Tuberculosis and Diabetic Mellitus, A Prospective Cohort Study.

Nexus Between Tuberculosis and Diabetic Mellitus, A Prospective Cohort Study.

Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome

Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae

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