Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho

Wang, Jian; Zhu, Zhanfang; Liu, Fuqiang; Liu, Cun; Ou-Yang, Ai-Mei; Chen, Weiwei; Wang, En-Guo; Wang, Ximing

doi:10.2147/ijgm.s300309

Cited by 3 publications

(1 citation statement)

References 45 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, it is important to mention that men were more likely to have a DELC compared to women, a finding that has only been reported recently: Wang et al report that in the group with DELC had the highest male/female ratio (M/F: 32/13) compared to controls without DELC (M/F: 24/21) [ 41 ]. A previous report mentioned that looking old for your age is a marker of poor cardiovascular health in both men and women [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most Important

Molina-Gallardo,

Aurelien-Cabezas,

Tiburcio-Jimenez

et al. 2024

International Journal of Hypertension

View full text Add to dashboard Cite

Introduction. Cardiovascular risk factors such as obesity, type 2 diabetes, hypertension, smoking, and dyslipidemia enfold heart disease morbimortality. Diagonal earlobe crease has been proposed as a prognostic marker of extension and severity of illness in patients with acute coronary syndrome. But its usefulness remains unclear in patients with or without coronary disease. Methods. A case‐control study was carried out on a total of 805 patients with and without cardiovascular risk factors or acute coronary syndrome. Univariate and multivariate binary logistic regression analyses were used to determine the probability of having diagonal earlobe crease with the presence of cardiovascular risk factors and acute coronary syndrome. Data were summarized as odds ratio with 95% confidence intervals and P values. Results. An unadjusted (univariate) analysis showed that being male, being older than 55 years, obesity, type 2 diabetes mellitus, arterial hypertension, smoking, and dyslipidemia, as well as having acute coronary syndrome, were associated with the presence of diagonal earlobe crease. The multivariate analysis showed that men (OR 1.6, 95% IC 1.1–2.4, P = 0.007), being over 55 years old (OR 4.8, 95% IC 3.2–7.2, P < 0.001), being obese (OR 2.1, 95% IC 1.4–3.1, P < 0.001), having arterial hypertension (1.5, 95% IC 1.1–2.3, P = 0.025), or suffering from acute coronary syndrome (OR 5.3, 95% IC 2.5–11.1, P < 0.001), were independent factors associated with diagonal earlobe crease. The rest of cardiovascular risk factors were not relevant in the multivariate model. Conclusions. In Mexican adults, having an acute coronary syndrome is not the only factor associated with diagonal earlobe crease but also being a man, older than 55 years, having high blood pressure and obesity. Diagonal earlobe crease may simply be caused by changes in the skin and connective tissues of the ears because of the aging process, obesity, and/or being male. These factors, by themselves, enfold cardiovascular risk due to well‐known pathophysiological causes.

show abstract

Section: Discussionmentioning

confidence: 99%

Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most Important

Molina-Gallardo,

Aurelien-Cabezas,

Tiburcio-Jimenez

et al. 2024

International Journal of Hypertension

View full text Add to dashboard Cite

show abstract

Regulatory and legal regulation of medical care in the «cosmetology» profile in the Russian Federation

Kubanov

Kolsanova²,

Chertukhina

2022

Medical Journal of the Russian Federation

View full text Add to dashboard Cite

The theoretical and methodological bases of the present study are scientific works, theoretical and methodological developments, current publications of domestic scientists, official normative legal acts, and description of their application in the practical activities of medical organizations providing cosmetology services. This study aimed to examine studies that have focused on the most pressing issues of the legal regulation of medical care to the population of the Russian Federation in the field of cosmetology, identify the main problems associated with the legal regulation of the industry, and summarize the proposals of medical organizations for its improvement. In the study, a survey study was conducted, which allowed researchers to identify and summarize the known literature on this topic, regardless of the publication type and study design. The study presents an analysis of the regulatory and legal regulations of the activities of employees and medical organizations providing services in the field of cosmetology. After completing the initial literature search, the authors analyzed, compared, summarized, and systematized the published information. The analysis made it possible to distribute the data obtained in several key areas of regulatory and legal regulation of domestic cosmetology, i.e., an excursion into history, regulatory and legal support for the activities of a cosmetology medical organization at the present stage, modern requirements for the activities of a doctor, in relation to medical cosmetology care. A content analysis was conducted on the use by medical organizations in the regions of the Russian Federation of the regulatory framework of the cosmetology industry, assessed its effect on the system of providing cosmetological care to the population at the present stage, identified several problems related to the legal regulation of the activities of medical cosmetology organizations and summarized proposals for its improvement.

show abstract

Klotho protein and atherosclerotic cardiovascular diseases: prolonging the thread of life

Alieva

Reznik

Teplova

et al. 2022

Medical Journal of the Russian Federation

View full text Add to dashboard Cite

To date, the most widely used biomarkers are natriuretic peptides and cardiac troponins. Many other biomarkers have also been identified, but only a few of them have found application in actual clinical practice. This review focuses on the Klotho protein and its role in cardiovascular diseases. In 1997, a gene that slows down the aging process was identified. It was named Klotho (Greek, ώ, spinning; Latin, Clotho; English, Klotho) in honor of the goddess of ancient Greek mythology, spinning the thread of life and being the personification of the steady, calm course of fate. Mice with an insertional mutation in the region of the Klotho gene promoter were characterized by premature aging processes. Three families of Klotho are known: -Klotho, -Klotho, and -Klotho, and the most studied is -Klotho. The Klotho protein consists of a large extracellular domain and a short C-terminal intracellular region. The extracellular domain consists of two repeat sequences called KL1 and KL2. -Klotho and -Klotho contain the KL1 and KL2 domains, respectively, and -Klotho contains only the KL1 domain. The Klotho gene in humans is located on chromosome 13q12 and consists of five exons. The Klotho protein is mainly expressed in the distal convoluted tubules of the kidneys and the vascular epithelial plexus of the cerebral ventricles. At lower concentrations, the Klotho gene is also found in other organs and tissues, particularly in the heart. Many studies have demonstrated the protective role of the Klotho protein in cardiovascular pathology. The pleiotropic properties of this protein are reflected in the diversity and interaction of cardioprotective mechanisms. The regulation of the concentrations of the Klotho protein in the blood and its expression in heart cells with the help of drugs can play a significant role in cellular metabolism and represent a promising target for the treatment of heart and vascular pathologies.

show abstract

Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho

Cited by 3 publications

References 45 publications

Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most Important

Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most Important

Regulatory and legal regulation of medical care in the «cosmetology» profile in the Russian Federation

Klotho protein and atherosclerotic cardiovascular diseases: prolonging the thread of life

Contact Info

Product

Resources

About