Patients with early age-related macular degeneration exhibit signs of macro- and micro-vascular disease and abnormal blood glutathione levels

Qin, Lu; Mroczkowska, Stephanie; Ekárt, Anikó; Patel, Samip; Gibson, Jonathan; Gherghel, Doina

doi:10.1007/s00417-013-2418-0

Cited by 17 publications

(12 citation statements)

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“…, ; Qin et al. ); however, with the methodology used in our own research being identical, these inconsistencies could also be attributed to other factors such as age. Indeed, the present study included a slightly younger group than our previous ones (Gherghel et al.…”

Section: Discussionmentioning

confidence: 68%

“…; Qin et al. ). This is generally possible due to the fact that the retinal microvascular response to flicker provocation is, in part, dependent on nitric oxide (NO) release, (Dorner et al.…”

Section: Introductionmentioning

confidence: 98%

“…; Qin et al. ). This possibility may be important for screening and early intervention, particularly in individuals free of overt vascular disease, but who belong to a group when age‐induced cardiovascular complications start to occur.…”

Section: Introductionmentioning

confidence: 98%

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Systemic circulatory influences on retinal microvascular function in middle‐age individuals with low to moderate cardiovascular risk

Seshadri

Mroczkowska

Qin

et al. 2014

Acta Ophthalmologica

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ABSTRACT.Purpose: To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD. Methods: Retinal vascular reactivity to flickering light was assessed in 102 healthy participants (46-60 years) by means of dynamic retinal vessel analysis (DVA). Other vascular assessments included carotid intima-media thickness (C-IMT) and blood pressure (BP) measurements. Total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and blood glutathione levels in its reduced (GSH) and oxidized (GSSG) forms were also determined for each participant, along with Framingham risk scores (FRS). Results: Retinal arterial baseline diameter fluctuation (BDF) was independently, significantly and negatively influenced by LDL-C levels (b = À0.53, p = 0.027). Moreover, the arterial dilation slope (Slope AD ) was independently, significantly and positively associated with redox index (GSH: GSSG ratio, b = 0.28, p = 0.016), while the arterial constriction slope (Slope AC ) was significantly and negatively influenced by blood GSH levels (b = À0.20, p = 0.042), and positively associated with FRS (b = 0.25, p = 0.009). Venous BDF and dilation amplitude (DA) were also negatively influenced by plasma LDL-C levels (b = À0.83, p = 0.013; and b = À0.22, p = 0.028, respectively). Conclusions: In otherwise healthy individuals with low to moderate cardiovascular risk, retinal microvascular dilation and constriction responses to stress levels are influenced by systemic antioxidant capacity, and circulating markers for cardiovascular risk.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 98%

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Systemic circulatory influences on retinal microvascular function in middle‐age individuals with low to moderate cardiovascular risk

Seshadri

Mroczkowska

Qin

et al. 2014

Acta Ophthalmologica

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“…In previous studies, we have already documented that individuals with various levels of cardiovascular risk exhibit abnormal retinal and venous responses to flicker-induced provocation (Mroczkowska et al 2012(Mroczkowska et al , 2013Patel et al 2012;Qin et al 2014). In the present study, in a sample with low CVD risk, decreases in the postflicker constrictory phase of retinal veins were apparent in the middle-aged and older individuals only.…”

Section: Discussionmentioning

confidence: 99%

Ageing effect on flicker‐induced diameter changes in retinal microvessels of healthy individuals

Seshadri

Ekárt

Gherghel

2015

Acta Ophthalmologica

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PurposeTo compare flicker‐induced retinal vessel diameter changes in varying age groups with low cardiovascular risk.MethodsRetinal vascular reactivity to flicker light was assessed by means of dynamic retinal vessel analysis in 57 participants aged 19–30 years, 75 participants aged 31–50 years and 62 participants aged 51–70 years participants. Other assessments included carotid intima–media thickness (c‐IMT), augmentation index (AIx), blood pressure profiles, blood lipid metabolism markers and Framingham risk scores (FRS).ResultsRetinal arterial dilation amplitude (DA) and postflicker percentage constriction (MC%) were significantly decreased in the oldest group compared to the middle‐aged (p = 0.028; p = 0.021) and youngest group (p = 0.003; p = 0.026). The arterial constriction slope (SlopeAC) was also decreased in the oldest group compared to the youngest group (p = 0.027). On the venous side, MC% was decreased in the middle‐aged and oldest groups in comparison with the youngest group (p = 0.015; p = 0.010, respectively). Additionally, men exhibited increased arterial DA (p = 0.007), and percentage dilation (MD%, p < 0.001) in comparison with women, but only in the youngest age group. Both AIx and c‐IMT scores increased with age (both p < 0.001); however, no correlations were found between the observed differences in the measured retinal vascular function and systemic parameters.ConclusionIn individuals with low cardiovascular risk, there are age‐related differences in flicker‐induced retinal vessel diameter changes throughout the entire functional response curve for arteries and veins. Gender differences mainly affect the arterial dilatory phase and are only present in young individuals.

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“…Korai AMD-vel diagnosztizált betegek a sziszté-más és retinalis elváltozások olyan jeleit mutatják, amelyek a későbbi cardiovascularis morbiditás ismert kocká-zati tényezői. AMD-s betegekben szignifi kánsan nagyobb az a. carotis-intima átlagos vastagsága és augmentációs indexe; a betegekben fokozott oxidált glutationt, alacsonyabb redoxindexet és emelkedett LDL-koleszterin-szintet mutattak ki [57,58].…”

Section: Az Emberi éRrendszer Egységessége éS Egylényegűségeunclassified

The age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesis

Fischer¹

2015

Orvosi Hetilap

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A szem struktúráit vérrel ellátó érendothelium működészavarának kulcsfontosságú a szerepe az időskori maculadegeneráció létrejöttében, és indirekt bizonyítékok arra utalnak, hogy az időskori maculadegeneráció érbetegség, végső soron az egész érrendszer megbetegedésének a része. Az ártalmak, a rizikófaktorok oxidatív stresszhez vezetnek, ami aktiválja az endothelt, és szövetkárosodás alakul ki. Az erek, így a szem érhártyájában, a chorioideában lévő erek falát is számos ismétlődő és/vagy elhúzódó inger éri, amelyek mechanikai, fi zikai, kémiai, mikrobiológiai, immunológiai, illetve genetikai eredetűek lehetnek. Bármilyen hosszan tartó/ismétlődő ártalom, amely működésbe hozza a védekezés láncreakcióját, gyulladást vált ki. Az ártalmas behatás eliminálásának sikertelensége endothelműködés-zavart, ér/szö-vet károsodást, időskori maculadegenerációt eredményez(het). Mindezek a tények arra utalnak, hogy az időskori maculadegeneráció érbetegség, az egész érrendszer megbetegedésének a része. Ami a kockázati tényezők jelenlé tében kialakuló endotheldiszfunkció és következményes időskori maculadegeneráció kiküszöbölésének, megelőzésének, illetve megszüntetésének stratégiáját illeti, számos jótékony nem gyógyszeres és farmakológiai intervenció áll rendelkezés-re: joggal várható, hogy az endotheldiszfunkció helyreállítása megakadályozza az érbántalom és így az időskori maculadegeneráció kialakulását vagy csökkenti a már kialakult elváltozást. Orv. Hetil., 2015, 156(9), 358-365.Kulcsszavak: időskori maculadegeneráció, endotheldiszfunkció, oxidatív stressz, kockázati tényező, prevenció, preventív terápiaThe age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesisThe wall of blood vessels including those in choroids may be harmed by several repeated and/or prolonged mechanical, physical, chemical, microbiological, immunologic, and genetic impacts (risk factors), which may trigger a protracted response, the so-called host defense response. As a consequence, pathological changes resulting in vascular injury (e. g. atherosclerosis, age-related macular degeneration) may be evolved. Risk factors can also act directly on the endothelium through an increased production of reactive oxygen species promoting an endothelial activation, which leads to endothelial dysfunction, the onset of vascular disease. Thus, endothelial dysfunction is a link between the harmful stimulus and vascular injury; any kind of harmful stimuli may trigger the defensive chain that results in infl ammation that may lead to vascular injury. It has been shown that even early age-related macular degeneration is associated with the presence of diffuse arterial disease and patients with early age-related macular degeneration demonstrate signs of systemic and retinal vascular alterations. Chronic infl ammation, a feature of AMD, is tightly linked to diseases associated with ED: AMD is accompanied by a general infl ammatory response, in the form of complement system activation, similar to that observed in de...

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Patients with early age-related macular degeneration exhibit signs of macro- and micro-vascular disease and abnormal blood glutathione levels

Abstract: Patients diagnosed with early AMD exhibit signs of systemic and retinal vascular alterations that correlated with known risk markers for future cardiovascular morbidity.

Cited by 17 publications

References 42 publications

Systemic circulatory influences on retinal microvascular function in middle‐age individuals with low to moderate cardiovascular risk

Systemic circulatory influences on retinal microvascular function in middle‐age individuals with low to moderate cardiovascular risk

Ageing effect on flicker‐induced diameter changes in retinal microvessels of healthy individuals

The age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesis

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