Patients with uterine leiomyoma exhibit a high incidence but low mortality rate for breast cancer

Shen, Te Chun; Hsia, Te Chun; Hsiao, Chieh Lun; Lin, Cheng Li; Yang, Chih Yi; Soh, Khay Seng; Liu, Liang‐Chih; Chang, Wen Shin; Tsai, Chia Wen; Bau, Da Tian

doi:10.18632/oncotarget.16520

Cited by 17 publications

(11 citation statements)

References 28 publications

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“…In addition, the mortality and risk of mortality were found to be lower in women with uterine leiomyomata who developed breast cancer. 6 This is in congruence with the results of Lindegard. 18 Tseng et al published a case-control study in 2017, which revealed a significant association between uterine leiomyoma and breast cancer (adjusted OR = 1.14; 95% CI = 1.07–1.21).…”

Section: Discussionsupporting

confidence: 89%

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A Study on Clinico-Pathological Profile of Breast Cancer Patients and Their Correlation With Uterine Fibroids Using Hormone Level and Receptor Status Assessment

Mohan

Kumar

Brahmachari

et al. 2022

Breast Cancer�(Auckl)

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Purpose: To study the clinico-pathological profile of breast cancer patients and the prevalence of uterine fibroids in them, their hormonal levels and hormone receptor status. Patients and methods: 52 patients with breast cancer who attended AIIMS Bhopal from November 2018 to January 2020 were selected, with their clinical details, triple assessment and other investigations for further management being performed and recorded. The presence of uterine fibroids was assessed using ultrasound of the abdomen, and for patients who had undergone hysterectomy, previous medical records were examined to ascertain the history of uterine fibroids. Serum levels of estrogen and progesterone were assessed using chemi-luminescent micro-particle immune assay (CMIA). Results: The mean age of patients was 50.35 ± 10.87 years. 36.54% of our patients had uterine fibroids, of whom 15.38% had undergone hysterectomy for the same, and 21.15% was detected on ultrasound of the abdomen during evaluation. Among patients with uterine fibroids, 84.2% were hormone receptor-positive, while in patients without uterine fibroids, only 57.6% had positive receptors. ( P = 0.049). Among premenopausal patients, there was a statistically significant difference in serum progesterone values between patients with and without uterine fibroids. Conclusion: The prevalence of uterine fibroids in our study group of breast cancer patients was found to be high. The role of estrogen and progesterone in the pathophysiology of both diseases and the common risk factors involved may biologically explain this finding. Breast cancer and other estrogen associated disorders may hold future research prospects.

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Section: Discussionsupporting

confidence: 89%

“…Only a few studies have looked into disorders associated with breast cancer, along with the hormonal assays, and these studies are all medical record-based. 5 , 6 In our literature search, we could not find any studies that evaluated hormonal levels while investigating the relationship between uterine fibroids and carcinoma breast.…”

Section: Introductionmentioning

confidence: 99%

A Study on Clinico-Pathological Profile of Breast Cancer Patients and Their Correlation With Uterine Fibroids Using Hormone Level and Receptor Status Assessment

Mohan

Kumar

Brahmachari

et al. 2022

Breast Cancer�(Auckl)

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“…A previous study used NHIRD and found a higher incidence rate of breast cancer among Taiwanese women with UM, and both diseases are strongly related by sex hormones. 17 Our study highlighted that women with UM have a higher risk of developing lung cancer.…”

Section: Discussionmentioning

confidence: 73%

Uterine myoma is associated with an increased risk of lung cancer: A nationwide population‐based cohort study

Sun

Chou

Lin

et al. 2021

Int. J. Clin. Pract.

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Objective: The rate of lung cancer in female patients is increasing, with different features from male patients being displayed. Hormonal factors could play a role. The association between the development of uterine myoma (UM) and female hormones has also been reported. The relationship between female lung cancer and UM may be due to the effect of female hormones. Methods: Data from 50 711 Taiwanese women with UM were retrieved from the National Health Insurance Research Database between 2000 and 2012. They were propensity-score matched with 50 711 women without UM (control group). A multivariate Cox proportional hazard regression model was used to compare the incidence of lung cancer between groups and to determine the hazard ratio of lung cancer in the UM group. Results:The risk of lung cancer was significantly higher in women with myoma (adjusted hazard ratio: 1.62, 95% confidence ratio = 1.24-2.12). Stratified analyses demonstrated that the significantly increased risk of lung cancer was more likely to be found in certain groups, such as women who (a) are of younger age, (b) have a midlevel income, (c) have the highest urbanisation level, (d) are office workers and (e) with a longer follow-up period of myoma. Furthermore, myomectomy did not affect the risk pattern. Conclusion:The results from this nationwide population-based cohort study suggested that UM is associated with a higher risk of developing lung cancer. However, the exact underlying mechanism accounted for this remains unclear, and our findings still need to be verified by further comprehensive studies elsewhere.

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“…A population-based study by Wise et al, in the USA, failed to find any association between the history of UL diagnosis and the overall incidence of breast cancer [ 5 ]. Two Asian studies based in Taiwan showed a higher incidence of breast cancer in patients with UL without increased mortality [ 6 - 7 ].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Breast Carcinoma, Uterine Myoma, and Ovarian Teratoma in a Single Woman

Das¹,

Bramhachari²,

Halder³

et al. 2021

Cureus

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Multiple primary tumors in a patient diagnosed with invasive ductal breast cancer are rarely reported in the literature. Here we present a case of invasive ductal carcinoma of the breast in a 42-year-old lady, with synchronous uterine leiomyoma (UL), ovarian teratoma and with prior history of follicular adenoma of thyroid in the same patient. The clinical presentation and management plan is discussed with a review of the literature. Breast cancer is the most common cancer in women where the concomitant occurrence of multiple primary tumors is a diagnostic and therapeutic challenge. In low- and middle-income countries, where facilities of genetic screening in all patients of synchronous neoplasia are limited due to scarcity of resources, strong clinical suspicion, multidisciplinary management, and follow-up remain important.

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Patients with uterine leiomyoma exhibit a high incidence but low mortality rate for breast cancer

Cited by 17 publications

References 28 publications

A Study on Clinico-Pathological Profile of Breast Cancer Patients and Their Correlation With Uterine Fibroids Using Hormone Level and Receptor Status Assessment

A Study on Clinico-Pathological Profile of Breast Cancer Patients and Their Correlation With Uterine Fibroids Using Hormone Level and Receptor Status Assessment

Uterine myoma is associated with an increased risk of lung cancer: A nationwide population‐based cohort study

Synchronous Breast Carcinoma, Uterine Myoma, and Ovarian Teratoma in a Single Woman

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