This paper presents a transistor-level verification flow to detect electrical overstress, static leakage and ESD-CDM issues in large low power SoC circuits. With innovative features like Spice patterns recognition and static voltage propagation by Calibre® PERC™, this approach brings significant added value to standard digital checkers that cannot capture some parts of the design in essence, such as analog IPs or third-party IPs designed outside power-intent driven flows. The results obtained on a 32nm CMOS circuit using multiple separate supplies with body biasing strategy, demonstrate the ability of this solution to cope with complex design architectures. As a matter of fact, some severe issues like hundreds of missing level shifters and weak input stages inside isolation cells were detected in few hours.