Pattern of acute blood transfusion reactions in Kano, North-Western Nigeria

Gwaram, Baffa A; Borodo, M M; Dutse, Abdulhamid I; Kuliya‐Gwarzo, Aisha

doi:10.4103/0331-8540.102110

Cited by 10 publications

(19 citation statements)

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“…There is a statistically significant relationship in developing transfusion reactions between pregnant women with previous history of transfusion and those without (see result above), this is similar to what was reported in Kano, North Western, Maiduguri, North Eastern and Ife, South Western Nigeria [11][12][13].…”

Section: Methodssupporting

confidence: 81%

“…Blood banking is crucial in blood transfusion services, and a lot has been said about stored blood and its possible effects which include depletion of clotting factors and development of transfusion reaction [11,14]. The longer the length of storage, the higher the risk of reaction, which was also found in our study to be statistically significant.…”

Section: Methodssupporting

confidence: 75%

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Acute Blood Transfusion Reactions in Pregnancy, an Observational Study from North Eastern Nigeria

Ibrahim¹

2013

J Blood Disord Transfus

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Blood transfusion is one of the key interventions in emergency obstetrics care and is known to save lives, however complications do occur. Pregnancy has certain peculiarities, which includes physiological changes, development of antigens against red cells, leucocytes and platelets. History of previous transfusion is common in pregnancy. The aim of this study is to find the incidence, presentations, types and risk factors for developing acute transfusions reaction in pregnancy. Materials and methods: Retrospective study of all blood transfusions in pregnancy between January to December 2012 at Federal Medical Centre Azare, Nigeria. Results: 1602 pregnant women received blood transfusion out of 15213, given a transfusion rate of 10.5% the mean age and parity were 28.3 ± 4.2 years and 6 ± 1 respectively. Acute reactions were found in 26.3%. Non heamolytic febrile reaction accounts for 47.7%. Allergic uticaria account for 24.5%. There was a significant relationship between stored blood and transfusion reactions, similarly, significant relationship was found between previous history of transfusion and transfusion reactions, but no difference was found between rise and full cross match and uncross match but ABO compatible blood in developing transfusion reactions. Conclusions: As blood transfusion alternatives are not readily available or not practical in pregnancy hemovigilance is the key to making blood transfusion safer.

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Section: Methodssupporting

confidence: 81%

Section: Methodssupporting

confidence: 75%

Acute Blood Transfusion Reactions in Pregnancy, an Observational Study from North Eastern Nigeria

Ibrahim¹

2013

J Blood Disord Transfus

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“…The find was consistent with studies conducted in Japan (5.05%), 12 India (3.4%), 24 Belgaum (4.41%), 25 and Nigeria (3.6%). 26 However, this finding was lower than a study conducted in different areas, namely, USA (16.5%) 27 and Nigeria (26.3%). 28 The observed difference might be due to a difference in study participants.…”

Section: Discussionmentioning

confidence: 63%

<p>Proportion of Acute Transfusion Reaction and Associated Factors Among Adult Transfused Patients at Felege Hiwot Compressive Referral Hospital, Bahir Dar, Northwest Ethiopia: A Cross-Sectional Study</p>

Gelaw¹,

Woldu²,

Melku³

2020

JBM

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Introduction: Acute transfusion reactions are adverse events occurring within 24 hrs of transfusion and cause simple-to-severe complications. They may vary with the blood component transfused and recipient factors. In Ethiopia, there is a limited evidence about the incidence and associated factors of transfusion reactions. Objective: To determine the proportion of acute transfusion reactions and associated factors among adult transfused patients. Methods: A total of 384 study participants were included in the study. Structured questionnaires were used for socio-demographic and past medical history data collection. Vital signs were measured as a baseline for every study participants and monitored and followed for 24 hrs. Laboratory tests like complete blood count, direct anti-human globulin test and urine hemoglobin were done as a baseline for suspected patients. Cross-match, blood grouping, and blood culture for patients and donors sample were also done for suspected patients. Descriptive statistics, bivariable and multivariable binary logistic regression were analyzed using SPSS version 20. P-value of <0.05 in the multivariable model was considered as statistically significant. Results: Acute transfusion reactions were observed in 5.2% of patients. Of total cases of acute transfusion reaction, the majority developed allergic reactions (65%) and febrile non-hemolytic transfusion reaction (30%). It was significantly associated with transfusion history (AOR=3.4; 95% CI: 1.2-9.7), abortion history (AOR=5.0; 95% CI: 1.5-16.4), longer blood storage time (AOR=5.1; 95% CI: 1.7-15.2) and receiving three or more unit of blood (AOR= 4.1; 95% CI: 1.5-11.2). Conclusion: Acute transfusion reactions were observed in 5.2% of patients (allergic reactions (65%), febrile non-hemolytic transfusion reaction (30%) and alloimmunization (5%)). Patients with a history of transfusion, abortion, transfused with blood stored ≥14 days and multi-transfused patients should be closely monitored.

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“…20 On the contrary, Gwaram BA study showed previous transfusion history increased the risk of getting transfusion reactions. 21 Pedrosa AKKV study found that previous history of transfusion was not significantly associated with the type of transfusion reactions. 22 These discrepancies may be explained because the study population characteristics (including race) and type of blood being used in the practice are different from one study to others.…”

Section: Discussionmentioning

confidence: 93%

Characteristics of Acute Transfusion Reactions and its related factors in Cipto Mangunkusumo Hospital Jakarta, Indonesia

Wahidiyat¹,

Marpaung²,

Iskandar³

2019

hsji

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Latar belakang: Reaksi transfusi akut (RTA) merupakan sekelompok kejadian yang tidak diinginkan akibat pemberian transfusi darah. Manifestasi dari RTA bervariasi dari yang ringan hingga mengancam nyawa. Saat ini, data mengenai reaksi transfusi di Indonesia masih sangat terbatas. Dalam studi ini, kami bertujuan untuk memberikan gambaran mengenai karakteristik RTA dan faktor-faktor yang mempengaruhinya. Metode: Studi ini merupakan studi retrospektif yang melibatkan 288 subyek dengan RTA. Studi dilakukan di Rumah Sakit Dr. Cipto Mangunkusumo, dimulai sejak Januari hingga Desember 2017. RTA dikelompokkan berdasarkan sistem tubuh yang mengalami manifestasi, serta derajat manifestasinya. Hasil: Sel darah merah merupakan produk darah utama yang ditransfusikan ke subyek, diikuti dengan konsentrat trombosit, plasma segar beku, dan kriopresipitat. Lima gejala utama dari RTA adalah gatal, demam/kenaikan suhu tubuh, menggigil, urtikaria, dan angioedema. Berdasarkan sistem tubuh yang terkena, umumnya RTA bermanifestasi sebagai gejala pada kulit (56.6%). Berdasarkan derajat manifestasinya, RTA umumnya dikategorikan dalam derajat ringan (55.9%). Anak-anak cenderung mengalami manifestasi yang ringan (64.8%) dan utamanya bermanifestasi pada kulit (65.4%). Riwayat transfusi mempengaruhi derajat RTA secara signifikan. RTA derajat sedang dan gejala konstitusional lebih banyak ditemukan pada subyek yang mendapat PRC dibanding produk darah lainnya. Kesimpulan: Umumnya RTA bermanifestasi sebagai gejala dermatologi. Hanya sedikit kasus RTA yang disebabkan oleh reaksi inkompatibilitas. Manifestasi dan derajat RTA juga dipengaruhi oleh umur, riwayat transfusi, dan jenis komponen darah. Kata kunci: Transfusi darah, reaksi transfusi akut, riwayat transfuse, usia Abstract Background: Acute transfusion reactions (ATRs) are a group of adverse events caused by blood transfusions. Manifestations of ATRs vary from mild to life threatening. At present, data about transfusion reactions in Indonesia are still limited. In this study, we aim to determine the characteristics of ATRs and its related factors. Methods: This was a retrospective study of 288 subjects with ATRs. The study was conducted in Cipto Mangunkusumo Hospital, started from January to December 2017. ATRs were categorized based on the body systems affected and degree of manifestations. Results: Packed red cells (PRC) was the predominant blood product (51.4%) which was transfused to subjects, followed by thrombocyte concentrate (TC), fresh frozen plasma (FFP), and cryoprecipitate. Five most common predominant symptoms of ATRs were pruritus/itch, febrile/increased temperature, chills, transient urticaria, and angioedema. Based on the affected body systems, the majority of ATRs manifested as dermatologic symptoms (56.6%). Based on the degree of manifestations, the majority of ATRs were categorized as mild degree (55.9%). Children tended to have milder symptoms (64.8%), which mostly manifested as dermatologic symptoms (65.4%). History of transfusion affected the degree of ATR significantly. Moderate degree of ATRs and constitutional symptoms were found more common in subjects who received PRC than other blood products. Conclusion: Most of ATRs manifest as dermatologic symptoms, which represent allergic reactions. Only a small portion of ATRs are caused by incompatibility reactions. The manifestation and degree of ATRs are also affected by age, history of transfusion, and type of blood components. Keywords: Blood transfusion, acute transfusion reaction, transfusion history, age

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Pattern of acute blood transfusion reactions in Kano, North-Western Nigeria

Cited by 10 publications

References 0 publications

Acute Blood Transfusion Reactions in Pregnancy, an Observational Study from North Eastern Nigeria

Acute Blood Transfusion Reactions in Pregnancy, an Observational Study from North Eastern Nigeria

<p>Proportion of Acute Transfusion Reaction and Associated Factors Among Adult Transfused Patients at Felege Hiwot Compressive Referral Hospital, Bahir Dar, Northwest Ethiopia: A Cross-Sectional Study</p>

Characteristics of Acute Transfusion Reactions and its related factors in Cipto Mangunkusumo Hospital Jakarta, Indonesia

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