Pattern of Candida species isolated from patients with diabetes mellitus and vulvovaginal candidiasis and their response to single dose oral fluconazole therapy

Goswami, Deepti; Goswami, Ravinder; Banerjee, Uma; Dadhwal, Vatsla; Miglani, Sunita; Lattif, Ali Abdul; Kochupillai, N.

doi:10.1016/j.jinf.2005.03.005

Cited by 89 publications

(67 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lactobacillus spp. could provide colonization resistance and prevent germination, maintaining low numbers of yeast; ii) pregnancy, a higher prevalence of vaginal colonization and symptomatic vaginitis are more often observed in pregnant women; iii) contraceptives, these increase vaginal colonization with Candida after the use of oral contraceptives with high estrogen content and in users of intrauterine contraceptive devices, contraceptive sponges, diaphragms, and condoms, with or without spermicides; iv) patients with DM; v) HIV infection, the number of women with HIV grew in the 1980s, vaginal candidiasis was also increasingly reported, and there is a tendency to isolate notably C. glabrata and Candida isolates notably with reduced sensitivity to fluconazole; vi) behavioral factors, the incidence of VVC increases in the second decade of life, corresponding to the onset of sexual activity, cultural differences affect the frequency of Candida species in some groups, women's culture and ethnicity influence their diet, hygiene, and sometimes the use of modern medicine, among other factors; vii) hypersensitivity, chemical contact, atopy, local allergy, or hypersensitivity reactions could alter the vaginal milieu and facilitate transformation from asymptomatic colonization into symptomatic vaginitis (Goswami et al, 2006;Sobel, 2007;Wei, et al, 2010;Fisher and Bradford, 2011).…”

Section: Predisposing Factorsmentioning

confidence: 99%

Use of antifungal Saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences

Herrera-Arellano¹,

López-Villegas²,

Rodríguez-Tovar³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X 2 , p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC.

show abstract

Section: Predisposing Factorsmentioning

confidence: 99%

Use of antifungal Saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences

Herrera-Arellano¹,

López-Villegas²,

Rodríguez-Tovar³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

show abstract

“…Interestingly, in a few small studies, C. glabrata was found to be the primary species isolated from diabetic (61.3%) and elderly (51.2%) patients with VVC (2,4,6,11). Often, these non-albicans species are associated with elevated MIC levels for the azoles, the most commonly prescribed class of antifungal drugs.…”

mentioning

confidence: 99%

Survey of Vaginal-Flora Candida Species Isolates from Women of Different Age Groups by Use of Species-Specific PCR Detection

et al. 2008

View full text Add to dashboard Cite

A retrospective survey of 93,775 samples testing positive in Candida species-specific PCR tests performed on cervicovaginal swabs over a 4-year period demonstrated consistent yearly distributions of Candida albicans (89%), C. glabrata (7.9%), C. parapsilosis (1.7%), and C. tropicalis (1.4%). However, the species distributions among different age groups revealed increases in the percentages of non-albicans species with increases in age.Vulvovaginal candidiasis (VVC) is a common fungal infection that affects healthy women of all ages. At least 75% of women will develop one or more infections once during their lifetime, with 5 to 8% of those individuals developing recurrent infections (5, 7). Current literature examining the species distribution of Candida isolates involved in VVC is limited; however, several important observations have been made. For example, one study shows that Candida albicans accounts for 70 to 90% of all VVC cases, with a recent emergence of nonalbicans species (10). The rise in VVC infections, more specifically in those caused by non-albicans species, could be due to several factors, ranging from an increase in over-the-counter antifungal use to an increase in high-risk patient populations (i.e., diabetics and menopausal women). Candida glabrata is the primary non-albicans species emerging in VVC, accounting for up to 14% of infections in immune-competent women (9, 10).In addition to an increase in non-albicans species overall, it is becoming clear that certain patient populations may experience higher risks of infection from these non-albicans species, often leading to limited treatment options. Interestingly, in a few small studies, C. glabrata was found to be the primary species isolated from diabetic (61.3%) and elderly (51.2%) patients with VVC (2, 4, 6, 11). Often, these non-albicans species are associated with elevated MIC levels for the azoles, the most commonly prescribed class of antifungal drugs. It has been well documented that C. glabrata demonstrates both intrinsically low susceptibility to the azoles and the ability to develop frank resistance (8,12,13,14,15,16). Moreover, a recent increase in the trailing phenotype, with low-level resistance to the azoles, has been observed for the Candida tropicalis isolates (1, 3). This highlights the importance of identifying Candida species within clinical samples in order to provide physicians with information concerning the proper treatment for their patients.

show abstract

“…Goswami et al 6 reported significantly higher prevalence of Candida colonisation in diabetic patients with poor glycaemic control. Grigoriou et al 7 isolated more CA from diabetic patients than from non-diabetics.…”

Section: Discussionmentioning

confidence: 98%

Candida albicans and Streptococcus pyogenes balanitis: diabetes or STI?

Maatouk¹,

Hajjar

Moutran³

2015

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

Pattern of Candida species isolated from patients with diabetes mellitus and vulvovaginal candidiasis and their response to single dose oral fluconazole therapy

Cited by 89 publications

References 18 publications

Use of antifungal Saponin SC-2 of <i>Solanum chrysotrichum</i> for the treatment of vulvovaginal candidiasis: <i>in vitro</i> studies and clinical experiences

Use of antifungal Saponin SC-2 of <i>Solanum chrysotrichum</i> for the treatment of vulvovaginal candidiasis: <i>in vitro</i> studies and clinical experiences

Survey of Vaginal-Flora Candida Species Isolates from Women of Different Age Groups by Use of Species-Specific PCR Detection

Candida albicans and Streptococcus pyogenes balanitis: diabetes or STI?

Contact Info

Product

Resources

About