Pattern of Cerebrospinal Fluid Lactic Dehydrogenase During Treatment of Bacterial Meningitis

Reference intervals for the activity of lactate dehydrogenase and its isoenzymes in the serum and cerebrospinal fluid of healthy canines

“…9,14,15 Cerebrospinal fluid LD activity and isoenzyme patterns have also proven clinically relevant in human medicine. Studies have found that LD isoenzyme distributions in the CSF can rapidly differentiate bacterial meningitis from aseptic meningitis in human patients, [16][17][18][19] and that CSF isoenzymes are altered in patients with Guillain-Barre syndrome 20 and multiple sclerosis. 21 Importantly, there have been very few studies regarding CSF LD activity in veterinary medicine, although there are indications that it could be a useful diagnostic tool for distinguishing between neurologic diseases that present similarly, such as infectious and noninfectious meningitis.…”

Determination of the effect of iatrogenic blood contamination on lactate dehydrogenase and creatine kinase activity in canine cerebrospinal fluid

“…These subunits combine to form five isoenzymes defined by the relative contribution of each type of subunit: H 4 , H 3 M 1 , H 2 M 2 , H 1 M 3 , M 4 , or LDH‐1, LDH‐2, LDH‐3, LDH‐4, and LDH‐5, respectively 3,4 . In people, studies indicate LDH activity is elevated in the CSF of patients with meningitis and that CSF LDH isoenzyme patterns can be used for the differentiation between bacterial and aseptic meningitis 5,6 . LDH isoenzyme activity can also help determine the status of the blood–brain barrier when LDH CSF and serum values are compared 7 .…”

“…3,4 In people, studies indicate LDH activity is elevated in the CSF of patients with meningitis and that CSF LDH isoenzyme patterns can be used for the differentiation between bacterial and aseptic meningitis. 5,6 LDH isoenzyme activity can also help determine the status of the blood-brain barrier when LDH CSF and serum values are compared. 7 In dogs, elevated CSF LDH has been identified as a biomarker of GM1 gangliosidosis, a lysosomal storage disease impacting the central nervous system (CNS).…”

Determination of optimal storage temperature and duration for analysis of total and isoenzyme lactate dehydrogenase activities in canine serum and cerebrospinal fluid

“…Human studies show that metastatic CNS tumors have an increased fraction of LDH‐5, while primary CNS tumors elicit an increase in all LDH isoenzymes . Furthermore, changes in the CSF LDH isoenzyme profile can be used to differentiate bacterial from aseptic meningitis in people …”