Pattern of Congenital Heart Disease in Infants of Diabetic Mother

Ferdousi, Shormin Ara; Sarker, Ferdousur Rahman; Jahan, Nasim; Fatema, Nurunnahar

doi:10.3329/bjch.v38i2.21140

Cited by 6 publications

(10 citation statements)

References 17 publications

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“…The fact that the poor diabetic control and hyperglycemia are associated with an increased risk of congenital malformation in offspring is well documented [15,16,17]. In this study the different echocardiography findings were PDA in 38.4 % and ASD in 7.7 % which is comparable to the study by Ferdousi et al [11] where PDA in 55.3%, ASD in 10.71% and VSD in 3.54%. Whereas VSD in 23.1% in our study and other findings as mentioned in Table 4.…”

Section: Resultssupporting

confidence: 84%

“…In published studies reported risk of maternal diabetes having teratogenic effect is 1.7-4.0 % [11]. In the studies of antenatal echocardiography and diabetic pregnancy it has been reported that there is an excess of cardiovascular malformations where the authors has concluded that the GDM has "increased risk" of cardiovascular malformation in infants and it is an indication for fetal echocardiography [11]. Increased risk of CHD has also been shown in a population-based case control study where it has showed that the overall risk of structural heart disease in infants born to maternal diabetes mellitus was 3.2 time higher than in non diabetic mother.…”

Section: Resultsmentioning

confidence: 99%

“…In only 1% of the cases, maternal disease is the cause [10]. In published studies reported risk of maternal diabetes having teratogenic effect is 1.7-4.0 % [11]. In the studies of antenatal echocardiography and diabetic pregnancy it has been reported that there is an excess of cardiovascular malformations where the authors has concluded that the GDM has "increased risk" of cardiovascular malformation in infants and it is an indication for fetal echocardiography [11].…”

Section: Resultsmentioning

confidence: 99%

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Echocardiographic Study of Congenital Heart Disease in Infants of Diabetic Mother

Shrivastava

Kafle²,

Shah³

2019

J Nobel Med Coll

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Background: Maternal diabetes mellitus (DM) has been shown to be high risk factor for congenital anomalies. It carries 3-5 times higher risk of incidence compared to the general population. The aims of present study is to investigate and portray the incidence of congenital heart disease in infants of diabetic mothers and know the utility of echocardiography in the early diagnosis of CHD at Nobel Medical College teaching hospital, a tertiary care centre in the eastern part of Nepal and review the current literature. Material & Methods: This is a prospective observational study conducted in Nobel Medical College Teaching hospital, Kanchanbari, Biratnagar Nepal over the period of 12 months. A structured questionnaire was designed which included demographic profile and the Echocardiography findings. The collected data were analysed using window’s SPSS version 20. Results: In the present study of the total deliveries 1.99 % was diabetic mother comprising 208 deliveries.127 had undergone echocardiography in which 10.2 % (n=13) had anomalies. One hundred sixteen were term and 11 were preterm. PDA was the most common anomaly (38.4%) followed by VSD (23.1%) and HCM (15.4%). Conclusion: With the review of current literature it has been found that maternal diabetes mellitus is a significant risk factor for congenital heart disease so it is suggested that the presence of diabetes mellitus in a pregnancy should be taken as a strong suspicious of having CHD and infants should be screened for the same .so as to diagnose the anomaly at the earliest possible.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Echocardiographic Study of Congenital Heart Disease in Infants of Diabetic Mother

Shrivastava

Kafle²,

Shah³

2019

J Nobel Med Coll

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“…Different studies showed that congenital anomalies occur three to five times more commonly in the IDM than in the general population. 12 In the present study, 100 IDM were subjected to ECG; of this, 28 (28%) babies had cardiac abnormality. Among them 5 babies had CCHD and 23 babies had ACHD.…”

Section: Discussionmentioning

confidence: 66%

Spectrum of Cardiovascular Abnormalities in Infants Born to Diabetic Mother in a Tertiary Care Center

et al. 2019

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Background Diabetes mellitus is one of the most common medical problems among pregnant women. Now, gestational diabetes mellitus (GDM) is increasing and amounts to 17% in Asian women but only in 4% of American and European women. In southern India, the prevalence of GDM is 17% in urban women, 13.8% in semiurban, and 9.8% in rural women. Aim The aim of the study is to find the cardiovascular abnormalities in infants born to a diabetic mother (IDM) and the association between infant’s heart lesion and diabetes mellitus in pregnant mother in a tertiary care center. Materials and Methods All babies born to both pregestational and gestational diabetic mother were included. Information regarding maternal type of diabetes, treatment regimen, maternal glycemic control status, antenatal ultrasonogram, baby’s sex, birth weight, gestational age, and clinical features were collected. Echocardiogram was done for all the babies. Results Out of the 100 IDM, 28 babies had cardiac disease, 5 babies had cyanotic heart disease, and 23 babies had acyanotic heart disease. Out of 100 diabetic mothers, 66 were on meal plan, 21 were on oral hypoglycemic agent (OHA) metformin, and 13 were on insulin therapy. Among 66 babies whose mother was on the meal plan, 8 had cardiac abnormality. Among the 21 mothers on OHA, 7 babies had cardiac abnormality and all the 13 babies of mothers who were on insulin had cardiac abnormality which was a significant finding among the IDM. Conclusion Maternal diabetes is a significant risk factor for heart disease in the newborn. Careful evaluation and early diagnosis of heart diseases in this high-risk group is of great value. Both pregestational and gestational diabetic mothers should monitor their blood sugar and maintain it in a normal range at the time of conception and early in pregnancy to reduce the risk of congenital heart disease in IDM.

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“…7 Ferdousi S. also reported the frequencies of patent Foramen Ovale (60.71%), PDA 55.3%, hypertrophic Cardiomyopathy (21.42%) and ASD (10.71%) in IDM babies in Bangladesh. 8 The aim of this study was to know the frequency of congenital heart diseases in infants born to diabetic mothers.…”

Section: Introductionmentioning

confidence: 99%

Congenital heart defects in neonates born to diabetic mother (IDM): A single center experience.

Shamoon

Zunaira

Ahsan³

et al. 2020

TPMJ

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Neonates born to diabetic mothers babies are more prone to develop congenital anomalies and defects. Overall risk of development of congenital malformations increases by 2-12% compared to normal neonates. In Pakistan, the true prevalence of CHD is unknown. Objectives: To determine the frequency of congenital heart diseases in infants born to diabetic mothers (IDM). Study Design: Cross Sectional Study. Setting: Pediatric Ward, Emergency and OPD, Allied Hospital, Faisalabad. Period: Six month after the approval of synopsis, August 16, 2017 to February 16, 2018. Material & Methods: Total 295 neonates born to diabetic mothers diagnosed presenting in neonatal unit were enrolled in study. Chest X-ray, electrocardiography (ECG) and echocardiography were done to identify CHDs. Results: Total 292 infants born to diabetic mother were selected. Mean age of the patients was 10.1±5.9 days. Of total, 189 (64.7%) were males and 103 (35.3%) were females. Out of 292 infants of diabetic mothers, 138(47.3%) were having various (CHD) and remaining 48(47.5%) were found normal after echocardiography. Conclusion: The cardiovascular system along with other systems of the body of neonates is affected in about 50% of the neonates born to diabetic mothers. Early diagnosis of CHD using a screening echocardiography is recommended to morbidity and mortality.

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Pattern of Congenital Heart Disease in Infants of Diabetic Mother

Cited by 6 publications

References 17 publications

Echocardiographic Study of Congenital Heart Disease in Infants of Diabetic Mother

Echocardiographic Study of Congenital Heart Disease in Infants of Diabetic Mother

Spectrum of Cardiovascular Abnormalities in Infants Born to Diabetic Mother in a Tertiary Care Center

Congenital heart defects in neonates born to diabetic mother (IDM): A single center experience.

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