Pattern of congenital malformations in newborn: a hospital-based study

Jain, Swapnil; Naik, J. D.; Dhakne, Babasaheb R.; Prabhu, Priya M.; Kamble, Sandesh V.; Mathurkar, Madhuri P.

doi:10.18203/2320-6012.ijrms20160308

Cited by 6 publications

(9 citation statements)

References 4 publications

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“…congenital rubella syndrome, Toxoplasmosis and maternal diabetes. Similar etiology were found in the studies done by Mosquera et al 24 and Wiener-Megnazi et al 26 In this study major birth defects were 78% and minor birth defects were 22%; it was similar to (60.71% vs. 33.29%) the study conducted by Chowdhury K et al 23 In this cross-sectional study, 27% neonates had multiple birth defects while 73% newborns had only single birth defects, which were similar to (15% vs. 85%) study done by Chowdhury K et al 23 and (8.3% vs. 91.7%) in study by Jain SR et al 27 and study by Mosquera et al 24 showed 37% babies with multiple birth defects and 63% cases with an isolated defect. Accordingly, in this study, 126 birth defects were found among 100 study subjects.…”

Section: Discussionsupporting

confidence: 86%

“…In this study, the birth defects were most commonly found in the cardiovascular system (i.e. 28%) among the system wise distribution of birth defects, followed by musculoskeletal system (24%), genitourinary system (18%) and gastrointestinal system (17%); similar results were found in study conducted by Mosquera et al 25 showed the most common birth defect was cardiac defects (75.2 per 10000) and by Jain et al 27 showed cardiac defects as the most common (29.6%). However, study by Zheng XY et al 25 showed the most common birth defect was neural tube defects (168 per 10000) and Desai NA et al 28 found that birth defects were most common in the musculoskeletal system (31.65%).…”

Section: Discussionsupporting

confidence: 84%

“…1 In the study done by Yang et al 18 the prevalence of birth defect was 1.5% and was 2.9% in the study by Mosquera et al 24 and in Bangladesh, it was 3.3% in the study conducted by Chowdhury K et al 23 There was a male predominance in birth defects i.e. 53% vs. 47% found in this study; the male-female ratio was 2.1:1 in the study done by Banu T et al 22 and 53% vs. 43.8% found in the study by Chowdhury K et al 23 and similar result was found in study conducted by Jain SR et al 27 (51.6% vs. 48.4%) and also by Zheng et al 25 In this study, etiology of birth defects was chromosomal anomaly e.g. Down syndrome, Edward syndrome etc.…”

Section: Discussionsupporting

confidence: 77%

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Frequency of Birth Defects in a Tertiary Care Hospital in Bangladesh

Amin

Pervez

Nur³

2020

Bangladesh J Child Health

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Background: Birth defects usually present at birth and may cause morbidity and mortality in the newborn. These defects may involve any organ system of the body. Gradually the incidence is rising due to various etiologies. The objective of the study was to find out the frequency, types and etiology of birth defects. Materials & Methods: This cross-sectional study was done in a tertiary care hospital in Bangladesh. In this study, 100 neonates with birth defects were enrolled, thoroughly examined, investigated and evaluated. Then collected data were analyzed. Results: The frequency of birth defects in this study was 1.54%. The most frequent birth defect was club foot deformity i.e. 11% and the most frequently involved organ system was cardiovascular system i.e. 28%. Among the birth defects 78% were major and only 22% were minor. Among those children with birth defect mortality was 17%; 41% were referred to advanced center and 42% were improved and discharged. In some of the cases with birth defect chromosomal anomaly, congenital infection (TORCH), maternal diabetes was found as causing factor. Conclusion: The frequency of birth defects was found 1.54% and most of the birth defects were major defect. Club foot deformity was found as the most common birth defect. Bangladesh J Child Health 2020; VOL 44 (1) :8-12

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 77%

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Frequency of Birth Defects in a Tertiary Care Hospital in Bangladesh

Amin

Pervez

Nur³

2020

Bangladesh J Child Health

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“…These results were slightly lower than in brazil (1%) [13]. Also, the incidence of congenital anomalies was 1.3% in Kuwait [14] 1.4% in India [15]. Furthermore, our results agreed with another study where the authors found that the predominance of congenital anomalies was 0.9% [16].…”

Section: Discussionsupporting

confidence: 87%

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Sayed¹,

Khalifa²,

Shehata³

et al. 2021

Clin J Obstet Gynecol

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Objective: To observe the predominance of fetal anomalies in pregnant women in a multi-centric setting. Methods: This prospective observational study included 20225 pregnant women who came for antenatal care in University Hospital and fetal medicine units from 2016 to 2019. Fetal anatomical scanning was done for all participants. Results: One hundred eighty-three cases had fetal congenital anomalies, yielding a prevalence of around 0.9%. Third of cases had positive consanguinity, this increased in cases of skeletal and thoracic anomalies. The presence of past history of anomalies was evident in 8.2% mostly with skeletal and heart anomalies. History of drug intake was only verified in 1.6% of cases. Sixty-three women out of 183 (34.4%) were diagnosed to have anomalies in fetal nervous system. Conclusion: Prenatal diagnosis are recommended for early detection of congenital anomalies and counselling.

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“…[8][9][10] Differently, other studies report higher frequency of CAs of the cardiovascular system. 5,[11][12][13] On the other hand, the higher frequency of CNS has been reported in several studies in Iran, 14 Japan, 15 Pakistan, 16,17 China, 18 Nigeria, 19 Tanzania, 20 and India. [8][9][10] The etiology of CNS anomalies is multifactor and involves complex interactions between genetic and environmental factors, constituting one of the most common congenital defects.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

Moraes

Melo

Amaral

2020

Rev Bras Ginecol Obstet

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Objective To evaluate the frequency of structural congenital anomalies (CAs) in the midwest of Brazil and its association with maternal risk factors. Methods This was a prospective, observational, case-control study based on a hospital population. Pregnant women attended at a fetal medicine service in Brazil were analyzed in the period from October 2014 to February 2016.A total of 357 pregnant women were included, 223 of whom had fetuses with structural anomalies (group case), and 134 of whom had structurally normal fetuses (control group). The clinical history was made previous to prenatal consultation, and the diagnosis of the structural CA was performed through ultrasound. Results A frequency of 64.27% (n = 223) of pregnant women with fetuses with structural anomalies was observed. The most frequent structural CAs were those of the central nervous system (30.94%), followed by anomalies of the genitourinary system (23.80%), and, finally, by multiple CAs (16.60%). The background of previous children with CAs (odds ratio [OR]: 3.85; p = 0.022), family history (OR: 6.03; p = < 0.001), and consanguinity between the progenitors (OR: 4.43; p = 0.034) influenced the occurrence of structural CA. Conclusion The most frequent CAs are those of the central nervous system, followed by those of the genitourinary system, and then multiple anomalies. The maternal risk factors that may have influenced the occurrence of structural CA were previous children with CA, family history, and consanguinity among the parents.

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Pattern of congenital malformations in newborn: a hospital-based study

Cited by 6 publications

References 4 publications

Frequency of Birth Defects in a Tertiary Care Hospital in Bangladesh

Frequency of Birth Defects in a Tertiary Care Hospital in Bangladesh

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

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