Pattern of Nasal and Paranasal Sinus Tumours in Owerri, Nigeria

Chukuezi, A. B.; Nwosu, Jones N.

doi:10.3923/rjmsci.2010.11.14

Cited by 4 publications

(11 citation statements)

References 18 publications

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“…There is a gap between the onset of symptoms and final diagnosis of the disease in most cases due to nonspecific manifestations of the paranasal malignancies, which misleads patients to receive treatment in an appropriate time ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

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Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Danesh-Sani

Sarafraz²,

Chamani³

et al. 2016

Med Oral

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BackgroundInadequate epidemiologic investigations of the paranasal sinuses malignancies prompted this retrospective study with special emphasis on a major group of 111 tumors.Material and MethodsClinical records of 111 patients with histologically confirmed malignant tumors of the paranasal sinuses were investigated retrospectively from April 2000 to January 2012. Collection of data included demographic information, clinical manifestations, treatment plans, and histopathology of the tumor.ResultsThere were 69 (62.16%) male and 42 (37.83%) female patients (male-to-female ratio of 1.6:1), with a median age of 49±12.2 years (range 21 to 88 years). A high level of occurrence was noticed in the fifth (26.3%) decade of life. The most frequent histological types were squamous cell carcinoma (43.5%) and adenoid cystic carcinoma (19%). Among clinical manifestations, nasal obstruction was the most frequent followed by diplopia, and facial swelling. Fifty three patients (47.74%) were treated with combined approach of surgery and radiation therapy.ConclusionsParanasal sinuses malignancies are rare conditions with nonspecific symptoms which make early diagnosis of the lesions more challenging. The optimal therapeutic protocol for patients suffering from these tumors is still a somewhat controversial entity and requires further studies. Key words:Paranasal sinuses, malignancy, surgery,radiotherapy.

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Section: Discussionmentioning

confidence: 99%

“…Epistaxis and diplopia more than any other symptoms may provoke patients for further medical consultation due to the fear of bleeding and visual impairment ( 19 ). In the present study, diplopia was the most frequent ophthalmic symptom in patients with SCC, adenocarcinoma, and malignant lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Danesh-Sani

Sarafraz²,

Chamani³

et al. 2016

Med Oral

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“…9 But works by Bush, et al, Gao, et al found auditory disturbance was a rare clinical symptom associated with maxillary carcinoma. 10,11 Based on Broder's grading system, in this study, 72% cases had well differentiated squamous cell carcinoma, followed by moderately differentiated in 12% cases, poorly and undifferentiated in 16% cases.…”

Section: Discussionmentioning

confidence: 57%

Squamous cell carcinoma of maxillary sinus: a comparison of clinico-radiological staging with pre-operative staging

Sudheer

Singh²

2018

Int J Otorhinolaryngol Head Neck Surg

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Background: The nasal cavity and paranasal sinuses are the site of origin of more complex, histologically diverse group of tumors which include neoplasms derived from mucosal epithelium, seromucinous glands and haematolymphoid cells. This study aimed to assess the incidence and prognosis of maxillary sinus malignancy.Methods: A total 25 (16 males, 09 females) malignancy cases between age group 11-70 years. All the cases were undergone with detailed clinical examination. The TNM staging system was followed to detect and standardize the disease stage. CT scan was used to identify the growth and extent of tumor. Results: Majority cases were between the age group 41-50 years (40%). Epistaxis was the commonest clinical symptom in 72% cases followed by nasal obstruction (68%), oral related symptoms (56%), oedema in cheeks (44%) and auditory disturbances in 16% cases. The TNM Staging system showed that 76% cases had T3 lesions, 16% had T4 lesions and 8% had T2 lesions. Nasal symptoms are commonly associated with malignancies and were belongs to T3 stage and few under T4.Conclusions: Maxillary sinus malignancy is an aggressive tumor normally diagnosed at the advanced stage, with minimal prognosis and reduced survival rate. Surgery in combination with radiotherapy followed by chemotherapy remains the best treatment modality.

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“…The rare nature of the tumors is almost a universal finding. [4,5,6,7] Epithelial tumors (18cases) predominated over nonepithelial tumors (4 cases) constituted 81.82%.The ratio of epithelial to nonepithelial tumors was 4.5:1. Male to female ratio was 2.1:1 similar to other studies (Lilly-Tariah da, 1999; Mundy et al, 1985 ;).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Analysis of Undifferentiated Malignant Neoplasms of the Sinonasal tract

Sundaramoorthy¹,

Srigayathri²,

Devadas³

2017

APALM

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Background: Sinonasal tumours are characterized by low incidence, non specific symptoms, and late presentation. Aggressive, nonsquamous cell epithelial and nonepithelial malignant neoplasms of varying histogenesis occurring in sinonasal region are grouped under the term undifferentiated malignant neoplasms. Frequently, these undifferentiated malignancies share clinical and light microscopic features, which make differentiation of one from the other virtually impossible without the use of adjunct immunohistochemical analysis .Methods: Undifferentiated malignant sinonasal tumors biopsied or surgically excised over a period of 5 years were studied. Result:We encountered 22 cases of undifferentiated malignant sinonasal tumors with an incidence of 0.05%, with a mean age of 41 to 50 years and the male to female ratio was 2.1:1. Epithelial tumors (18 cases) constituting 81.82 % predominated over non epithelial tumors (4 cases) constituting 18.18% with a ratio of 4.5:1. 16 tumors involved the nasal cavity (72.7%) and 6 involved paranasal sinuses (27.3%). The most common clinical presentation was mass in the nose 19 cases (86.36%). The most common Undifferentiated malignant tumor encountered was Sinonasal undifferentiated carcinoma-10 cases (45.45%). Conclusion:A variety of undifferentiated malignant neoplasms occur in the sinonasal tract with overlapping clinical and pathologic findings. In limited biopsy material, differentiation of these tumor types can be challenging and differentiating these tumors with the help of immunohistoochemistry has clinical importance because advances in therapeutic intervention may increase survival with good quality of life, and in some instances may achieve a cure. Keywords

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Pattern of Nasal and Paranasal Sinus Tumours in Owerri, Nigeria

Cited by 4 publications

References 18 publications

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Squamous cell carcinoma of maxillary sinus: a comparison of clinico-radiological staging with pre-operative staging

Clinicopathological Analysis of Undifferentiated Malignant Neoplasms of the Sinonasal tract

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