Pattern of skin bacteria in palmar arsenical keratosis

Self Cite

<p class="Abstract">The aim of this study was to examine the pattern of fungi in palmar arsenical keratosis. The skin swab was taken from the five different sites (palm, dorsum, axilla, front and back of the chest) of arsenicosis patients (n=37), arsenic exposed volunteers (n=20) and healthy volunteers (n=20) of an arsenic endemic area. Fungi were cultured in the Sabouraud dextrose agar media. The skin of the healthy volunteers contained only four species of fungi: Aspergillus, Dermatophytes, Mucor and Fusarium. The incidence of each fungus was low (0-4 out of 20 cases). The chronic exposure to arsenic did not alter the pattern of fungi. However, the patient of arsenicosis showed increased inci-dence of Aspergillus and Dermatophytes species and decreased incidence of Mucor species. The supplementation of iron and folic acid to the patient for 12 weeks reduced the incidence of Aspergillus (only in axilla), Dermatophytes (only in palm) and increased the incidence of Mucor (all the sites except palm). In conclusion, skin fungi are altered in arsenicosis irrespective of intake of high concentration of arsenic.</p>

Section: Collection Of Specimensmentioning

confidence: 99%

Section: Fisher Exact Test Was Donementioning

confidence: 99%

See 1 more Smart Citation

Pattern of skin fungi in palmar arsenical keratosis

Moitra

Misbahuddin

Sattar

2018

Self Cite

“…Enrolment of the patients was performed according to the inclusion and exclusion criteria (Ferdous and Misbahuddin, 2014;Khalil et al, 2016).…”

Section: Enrolment Of Patientsmentioning

confidence: 99%

“…There is a clinical improvement of keratosis and melanosis after giving of spirulina extracts plus zinc in arsenicosis patients (Misbahuddin et al, 2006). Vitamin E capsule for 12 weeks also improves the palmar arsenical keratosis (Khalil et al, 2016). However, these systemic drugs and nutritional supplements require a longer duration of treatment that may affect the compliance of the patients.…”

Section: Introductionmentioning

confidence: 99%

Effect of cock’s comb extract in the treatment of palmar arsenical keratosis

Anny¹,

Misbahuddin²

2019

Self Cite

The aim of this study was to examine the effect of cock’s comb extract in the treatment of moderate palmar arsenical keratosis (n = 35). All the patients were provided cock’s comb extract ointment to apply topically twice daily for 12 weeks. Adherence to the ointment and adverse effects were monitored regularly through the phone call and during the visit of each patient. Photographs of both palms were collected before and after treatment. Clinical improvement was assessed by measuring the arsenical keratotic nodular size of the both palms before starting the treatment and after completion of the treatment. The mean (± SD) sizes of the nodules before the study was 33.6 ± 16.8, which reduced to 5.4 ± 5.2 after completion of the study. This change (84% reduction) was statistically significant. None of the patients reported to any adverse effect during this study period. In conclusion, cock’s comb extract can be used effectively as a topical treatment of the palmar arsenical keratosis.

Effects of tetracycline and clotrimazole ointments in the treatment of palmar arsenical keratosis

Ferdous

Misbahuddin

Sattar

2020

Self Cite

The study was designed to see the effects of tetracycline and clotrimazole on the altered skin flora (Aspergillus and Enterobacter species) in 38 patients with palmar arsenical keratosis. The skin swab and scrapping samples were collected. Tetracycline, clotrimazole and their combination were given as ointment for 3 months. Clotrimazole and tetracycline were found to inhibit the growth of Aspergillus spp. and Enterobacter spp. in vitro. A pH-dependent inhibition of the growth of microorganisms in presence of these antimicrobials was observed, which was highest at pH 8. The percentage reduction of keratotic nodular size was 32.9, 66.1, 61.1 and 32.5 in the groups treated with placebo, tetracycline, clotrimazole and the combination of both, respectively. But none of the interventions was proved statistically significant. No remarkable adverse effect was reported. In conclusion, clotrimazole or tetracycline inhibits the growth of Aspergillus spp. or Enterobacter spp. in vitro. However, there was no statistically significant clinical improvement of the palmar arsenical keratosis.