Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome

Abstract

BackgroundThyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of MetS. It is possible that coexistence of these two disease entities and unrecognized TD in patients with MetS might substantially increase ASCVD risk. Moreover, little is known about the relationship between TD and the components of MetS. Thus, the purpose of this study was to evaluate the pattern of TD in patients with MetS and its relationship with components of the MetS.MethodsA total of 358 previously diagnosed patients with MetS were recruited in the study. The thyroid function test parameters were measured to classify TD at Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Nepal. Statistical analyses were performed using SPSS version 16.0 to evaluate pattern and relationship.ResultsThe overall prevalence of TD in patients with MetS was 31.84% with high prevalence of subclinical hypothyroidism (29.32%). We found no evidence of a relationship between TD and components of MetS, although there was significant difference in waist circumference between four groups of TD.ConclusionPatients with MetS had subclinical hypothyroidism greatly. Although there was no evidence of any relationship between thyroid status and all components of MetS, TD should be taken into account when evaluating and treating patients with MetS to reduce the impending risk.

Study of thyroid function in patients with metabolic syndrome

“…These finding were similar to those obtained in the studies on Hispanic population by Garcia GJ et al, Nepal population Gyawali P et al, and Chennai population by Shantha GP et al 10,12,13 Serum triglycerides and TG/HDL-C ratio, which are surrogate markers for insulin resistance, were significantly elevated in study group compared to control group. This indicates that the study group may have greater insulin resistance than the control group.…”

“…Another study from Nepal showed that the prevalence of TD in patients with MetS was 31.84% and its pattern showed high prevalence of SCH (29.32%) followed by hypothyroidism (1.67%) and subclinical hyperthyroidism (0.83%). 12 . In this study, the mean BMI, waist circumference, waist/hip ratio, systolic and diastolic blood pressure, fasting blood glucose, triglycerides, were significantly higher and HDL-C levels were significantly lower in the study group (P<0.001) than in the control group.…”

“…The above results are in agreement with previous studies showing an association between metabolic syndrome and thyroid dysfunctions. [9][10][11][12] A study done by Meher LK et al showed a high prevalence of SCH (22%) and overt hypothyroidism (4%) in the MetS subjects. 9 In addition, similar study from India has shown a high prevalence of SCH (21.90%) and overt hypothyroidism (7.40%) in patients with MetS.…”

Thyroid disorders in obese patients. Does insulin resistance make a difference?

“…Lately, there has been increased interest in the effects of IR and MS on the thyroid (1-3). The association of IR and MS with thyroid diseases has been reported by several studies that have shown an increased incidence of hypothyroidism, autoimmune thyroiditis, thyroid nodules, and differentiated thyroid carcinomas along with other systemic malignancies (4,5). Patients with both POS and IR have been described as having an increased frequency of thyroid disorders such as hypothyroidism, Hashimoto's thyroiditis, and Graves' disease (6).…”

Study of Thyroid Profile in Geriatric Type-2 Diabetics in Jharkhand

“…Altered serum thyroid-stimulating hormones (TSHs) levels with normal or altered thyroid hormone, free triiodothyronine (FT3) and free thyroxine (FT4) is defined as thyroid dysfunction [2]. Different TDs include Hashimoto's thyroiditis, hyperthyroidism, and hypothyroidism [3].…”