Pattern of Uveitis in a Tertiary Ophthalmology Center in Thailand

Sukavatcharin, Somsiri; Kijdaoroong, Ornsirin; Lekhanont, Kaevalin; Vallipakorn, Sakda Arj-Ong

doi:10.1080/09273948.2016.1215475

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…Over time, the evolvement and advancement of diagnostic tools and imaging techniques have enhanced the way we diagnose and manage uveitis patients [2]. As the common causes of uveitis vary worldwide, the incidence for certain uveitides may differ according to region [3][4][5][6][7][8][9]. Understanding the epidemiology and causes of uveitis in various regions will further aid clinicians in a targeted approach to managing patients with diagnostically challenging uveitis.…”

Section: Introductionmentioning

confidence: 99%

Demography and clinical pattern of newly diagnosed uveitis patients in Malaysia

Rajan

Mohamed²,

Salowi

2022

J Ophthal Inflamm Infect

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Introduction Uveitis is one of the common causes of visual impairment in Malaysia. It remains a challenging entity to diagnose and manage due to variation in its clinical presentation. This study aims to observe the demographic and clinical pattern of cases from the participating ophthalmology units in Malaysia. Methods This study involved prospective and multicentered data collection for patients newly diagnosed with uveitis from 1st January 2018 to 31st December 2018. Variables collected and analyzed included age, gender, ethnicity, nationality, state of origin, laterality, granulomatous or non-granulomatous uveitis, and etiology of uveitis. Results A total of 1199 newly diagnosed uveitis patients were analyzed within the study period. There was a significant association between the anatomical location of uveitis with age at presentation. The percentage of patients with anterior uveitis was higher in the ‘40 to 60’ years and ‘above 60’ years age groups at 52.1% (n = 210) and 61.3% (n = 114) respectively. In contrast the percentage of patients with posterior and panuveitis was higher in the 1 to 20 and 20 to 40 years age groups at 51.4% (n = 54) and 48.7% (n = 246) respectively. Sixty three percent of the patients presented with unilateral uveitis (n = 760, p < 0.001) vs bilateral. Non-granulomatous uveitis comprised 84.5% of all patients (n = 1013, p < 0.001) compared to granulomatous uveitis. Non-infectious etiology contributed to 65.7% of all patients (n = 788, p < 0.001) with the majority being unclassifiable uveitis (n = 686, 57.2%,). Specific inflammatory entities contributed to only 8.5% (n = 102) of the non-infectious causes with Vogt-Koyanagi-Harada (VKH) syndrome being the most common (n = 25, 2.1%,). Infectious uveitis comprised 34.3% (n = 411) with tubercular (TB) uveitis (n = 105, 8.8%) and viral uveitis (n = 107, 8.9%) contributing the most followed by ocular Toxoplasmosis (n = 93,7.8%).] Conclusion This study has highlighted the demographic data and common causes of uveitis in Malaysia.

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Section: Introductionmentioning

confidence: 99%

Demography and clinical pattern of newly diagnosed uveitis patients in Malaysia

Rajan

Mohamed²,

Salowi

2022

J Ophthal Inflamm Infect

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“…Gender predilection of VKH disease seems to vary globally. Studies from the Philippines and India have suggested that women are affected more frequently than men, whereas men and women are equally represented in other studies from the Asia-Pacific region [24,25,43,85].…”

Section: Epidemiologymentioning

confidence: 91%

“…Studies in China, Taiwan, and Thailand have revealed relatively consistent patterns of uveitis. Noninfectious uveitis represents 41-55% of cases in China and 38-44% in Thailand [5,6,8,[40][41][42][43]. It also represents the majority of uveitis cases in Taiwan, accounting for 47-83% of etiologies [44][45][46].…”

Section: Epidemiology and Distribution Of Etiologiesmentioning

confidence: 99%

Noninfectious uveitis in the Asia–Pacific region

Hsu

Huang

Tao

et al. 2018

Eye

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Uveitis is a sight-threatening disease. Up to 35% of patients may have impaired vision. Inflammation of the uvea tissue has more than 60 etiologies. Previous reports have shown that 20-40% of uveitis cases were noninfectious. Some of them may be associated with systemic rheumatological and autoimmune diseases but some may affect the eyes only. The epidemiology and clinical situations of some specific uveitis entities vary worldwide because they are influenced by genetic, ethnic, environmental, and socioeconomic factors. The Asia-Pacific region comprises more than 30 countries. Epidemiology and patterns of uveitis vary greatly in this region. However, some uveitis entities, such as Behcet's disease, sarcoidosis, and Vogt-Koyanagi-Harada disease, are more common in this region. Many studies on the epidemiology, risk factors, and immune pathogenesis of this disease have been conducted. In this article, we review the epidemiology of noninfectious uveitis and special situations of these three uveitis entities in the Asia-Pacific region.

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“…This explains the great heterogeneity of the studies reported in the literature. The main etiologies (mostly reported from tertiary centers) are Vogt-Koyanagi-Harada disease (VKH) and sarcoidosis in Japan [7], VKH and Behçet's disease (BD) in China [8], BD in Turkey [9], HLA-B27-associated uveitis in Australia [10], herpesvirus in North Africa [11] and Thailand [12], tuberculosis in India [13], toxoplasmosis in South America [14], and infections (presumed tuberculosis, followed by cytomegalovirus infection and herpesvirus infection) in Singapore [15]. In Western countries, approximately a quarter of cases are related to ophthalmologic entities, a quarter to systemic diseases meeting consensual diagnostic criteria, a quarter to suspected systemic diseases, and a quarter to unexplained causes [16].…”

Section: Introductionmentioning

confidence: 99%

Uveitis as an Open Window to Systemic Inflammatory Diseases

Jammal

Loria

Jamilloux

et al. 2021

JCM

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Spondyloarthritis (Spa), Behçet’s disease (BD) and sarcoidosis are major systemic inflammatory diseases worldwide. They are all multisystem pathologies and share a possible ocular involvement, especially uveitis. We hereby describe selected cases who were referred by ophthalmologists to our internal medicine department for unexplained uveitis. Physical examination and/or the use of laboratory and imaging investigations allowed to make a diagnosis of a systemic inflammatory disease in a large proportion of patients. In our tertiary referral center, 75 patients have been diagnosed with Spa (n = 20), BD (n = 9), or sarcoidosis (n = 46) in the last two years. There was a significant delay in the diagnosis of Spa-associated uveitis. Screening strategies using Human Leukocyte Antigen (HLA)-B27 determination and sacroiliac magnetic resonance imaging in patients suffering from chronic low back pain and/or psoriasis helped in the diagnosis. BD’s uveitis affects young people from both sexes and all origins and usually presents with panuveitis and retinal vasculitis. The high proportion of sarcoidosis in our population is explained by the use of chest computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography CT that helped to identify smaller hilar or mediastinal involvement and allowed to further investigate those patients, especially in the elderly. Our results confirm how in these sight- and potentially life-threatening diseases a prompt diagnosis is mandatory and benefits from a multidisciplinary approach.

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Pattern of Uveitis in a Tertiary Ophthalmology Center in Thailand

Abstract: Herpetic uveitis was the commonest form of infectious uveitis, whereas Vogt-Koyanagi-Harada disease was most frequently seen as the non-infectious cause of uveitis in Thailand.

Cited by 16 publications

References 20 publications

Demography and clinical pattern of newly diagnosed uveitis patients in Malaysia

Demography and clinical pattern of newly diagnosed uveitis patients in Malaysia

Noninfectious uveitis in the Asia–Pacific region

Uveitis as an Open Window to Systemic Inflammatory Diseases

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