2008
DOI: 10.4049/jimmunol.180.9.6255
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Pattern Recognition Molecule Mindin Promotes Intranasal Clearance of Influenza Viruses

Abstract: The innate immune response is essential for host defense against microbial pathogen infections and is mediated by pattern recognition molecules recognizing pathogen-associated molecular patterns. Our previous work has demonstrated that the extracellular matrix protein mindin functions as a pattern recognition molecule for bacterial pathogens. In this study, we examined the role of mindin in influenza virus infection. We found that intranasal infection of mindin-deficient mice by influenza virus resulted in dra… Show more

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Cited by 30 publications
(29 citation statements)
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“…Therefore, we could observe the effect of galectin-1 on the inhibition of influenza virus-induced hemagglutination in such assay conditions. This result agrees with previous reports demonstrating that lectins can inhibit the activities of hemagglutinin of a variety of viruses (18,35,36). binding of galectin-1 to the surface of influenza A virus is not restricted to influenza A/WSN/33 virus, different subtypes of influenza A viruses were used for the binding assay.…”
Section: Galectin-1 Expression Is Upregulated In Mice Infected With Isupporting
confidence: 83%
“…Therefore, we could observe the effect of galectin-1 on the inhibition of influenza virus-induced hemagglutination in such assay conditions. This result agrees with previous reports demonstrating that lectins can inhibit the activities of hemagglutinin of a variety of viruses (18,35,36). binding of galectin-1 to the surface of influenza A virus is not restricted to influenza A/WSN/33 virus, different subtypes of influenza A viruses were used for the binding assay.…”
Section: Galectin-1 Expression Is Upregulated In Mice Infected With Isupporting
confidence: 83%
“…For example, the collectin family of mammalian C-type lectins including surfactant proteins A and D, mannose-binding protein and conglutinin, which are expressed in the airway and alveolar epithelium, can bind to influenza virus, act as opsonins and inhibit influenza virus HA activity [103107]. The extracellular matrix protein mindin can interact with influenza virus particles directly and enhance the clearance of influenza virus in the lung tissue [108]. Defensins can directly inactivate influenza A virus [109] and the θ-defensin retrocyclin-2 inhibits influenza virus infection by blocking membrane fusion mediated by the viral HA [110].…”
Section: Adjuvant-combined Intranasal Influenza Vaccinesmentioning
confidence: 99%
“…Mindin has been known to essentially initiate innate immunity and serve as a bridge between innate and adaptive immunity [6]. Previous reports indicated that mindin-deficient mice had an impaired capability to clear influenza virus and bacterial infection, and mindin-deficient macrophages exhibit defective responses to a broad spectrum of microbial stimuli.…”
Section: Introductionmentioning
confidence: 99%
“…This is because mindin is a pattern recognition molecule and can directly bind to sugar moieties in bacterial cell walls [7] and influenza virus particles to initiate innate immune responses, as well as function as an opsonin for macrophage phagocytosis of bacteria [8]. Interestingly, even recombinant mindin alone is capable of promoting viral clearance in wild-type mice [6]. Possible mechanisms for mindin’s effects on immunity system include binding to a cell surface receptor, activating synergistic signal transduction pathways for proinflammatory cytokine production, interacting with other pattern recognition receptors (PRR) (such as the Toll-like receptors) and enhancing their recognition of bacterial products, inducing bacterial phagocytosis to enhance the immune response to infection, or a combination of these mechanisms [7].…”
Section: Introductionmentioning
confidence: 99%