2016
DOI: 10.1039/c5nr08327c
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Patterned porous silicon photonic crystals with modular surface chemistry for spatial control of neural stem cell differentiation

Abstract: We present a strategy to spatially define regions of gold and nanostructured silicon photonics, each with materials-specific surface chemistry, for azide-alkyne cycloaddition of different bioactive peptides. Neural stem cells are spatially directed to undergo neurogenesis and astrogenesis as a function of both surface properties and peptide identity.

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Cited by 14 publications
(8 citation statements)
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“…Indeed, the patterning of BFs themselves can be of interest for the precise patterning of polymer films or materials to generate controlled templates by the BF method. Potential applications are textured surfaces, , responsive surfaces, filtration, or catalysis . Patterned BFs could also find utilizations in patterned chemistry for biomedical utilizations, , in aqueous media. For the generation of a controlled BF pattern, 0.2 μL of water droplets was deposited on a silicon wafer surface in the shape of a ring, then condensation was performed after complete evaporation.…”
Section: Resultsmentioning
confidence: 99%
“…Indeed, the patterning of BFs themselves can be of interest for the precise patterning of polymer films or materials to generate controlled templates by the BF method. Potential applications are textured surfaces, , responsive surfaces, filtration, or catalysis . Patterned BFs could also find utilizations in patterned chemistry for biomedical utilizations, , in aqueous media. For the generation of a controlled BF pattern, 0.2 μL of water droplets was deposited on a silicon wafer surface in the shape of a ring, then condensation was performed after complete evaporation.…”
Section: Resultsmentioning
confidence: 99%
“…For example, their long-range ordered structures provide a stable code that can direct the growth of nerve cells according to changes in the refractive index. Huang et al presented that lithographically patterned microporous silicon photonic crystals, which are functionalized with different bioactive peptide-doped surfaces, could be used as a spatial guidance for NSC differentiation and that NSCs can be spatially specified to suffer astrogenesis or neurogenesis as a multifunction of peptide identity as well as surface properties [58]. In addition, these crystals have found applications in the field of biomedical optics, and it has been shown that adsorbing proteins to the surface of a photonic crystal changes the refractive index which can be used to detect neurotransmitters and neural markers.…”
Section: The Application Of Photonic Crystals In Neuroengineeringmentioning
confidence: 99%
“…The last two decades have witnessed the increasing application of PSi in drug delivery, bio‐imaging, bio‐sensing, tissue engineering, and immunotherapy [11,12]. In addition, PSi has been widely used in many fields including optoelectronic devices [13,14], chemical sensors [15–18], energy conversion and storage [19–24], etc.…”
Section: Introductionmentioning
confidence: 99%