Patterning Reactive Microdomains inside Polydimethylsiloxane Microchannels by Trapping and Melting Functional Polymer Particles

Yamamoto, Masashi; Yamada, Masao; Nonaka, Nobuhiro; Fukushima, Shizuka; Yasuda, Masahiro; Seki, Minoru

doi:10.1021/ja804803s

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…S urface modification has become a critical component of micro-and nanofabrication with applications in technologies ranging from biodetection 1,2 to catalysis 3,4 and many more [5][6][7][8] . Many of these applications exploit non-covalent interactions and molecular recognition.…”

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confidence: 99%

Super-resolution surface mapping using the trajectories of molecular probes

2011

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The surface characterization of 'soft' materials presents a significant scientific challenge, particularly under 'wet' in situ conditions where a wide variety of non-covalent interactions may be relevant. Here we introduce a new chemical imaging method, mAPT (mapping using accumulated probe trajectories) that generates images of surface interactions by distributing different aspects of molecular probe trajectories into distinct locations and then combining many trajectories to generate spatial maps. The maps are super-resolution in nature, because they are accumulated from highly localized single-molecule observations. unlike other super-resolution techniques, which report only photon or point counts, our analysis generates spatial maps of physical quantities (adsorption rate, desorption probability, local surface diffusion coefficient, surface coverage/occupancy) that are directly associated with the molecular interactions between the probe molecule and the surface. We demonstrate the feasibility of this characterization using a surface patterned with various degrees of hydrophobicity.

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confidence: 99%

Super-resolution surface mapping using the trajectories of molecular probes

2011

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“…GPTMS was first silanized on the PDMS surface. Since its glycidoxy group becomes reactive to amino groups in basic solutions, PEG-NH 2 was then readily covalently attached to GPTMS on PDMS with high efficiency [39].…”

Section: Surface Modificationmentioning

confidence: 99%

Environmentally friendly surface modification of PDMS using PEG polymer brush

et al. 2009

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A PEG-NH2-based environmentally friendly surface modification strategy was developed for PDMS microchips to prevent protein adsorption and to enhance separation performance. PEG-NH2 was synthesized using a modified synthesis procedure. A two-step grafting method was used for PDMS modification. FTIR absorption by attenuated total reflection and contact angle measurements verified the successful grafting of PEG-NH2 onto the PDMS surface. Subsequent EOF Measurements and protein adsorption studies of PEG-modified PDMS microchips revealed noticeable EOF suppression and resistance to nonspecific protein adsorption for more than 30 days. Separation of four FITC-labeled amino acids was further demonstrated with high repeatability and reproducibility. Comparison of electrophoresis of 3-(2-furoyl)quinoline-2-carboxaldehyde-labeled BSA using PDMS microchips before and after surface modification resulted in significantly improved electrophoretic performance of the PEG-modified PDMS microchips, suggesting that our PEG grafting method successfully modified PDMS surface property and prevented adsorption of proteins. We expect that this environmentally friendly surface modification method will be useful for future protein separations with long-term surface stability.

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“…The assembly of small parts or components, which are not compatible with standard photolithography-based fabrication technologies, onto a substrate to form desired patterns is a difficult task that has been receiving considerable attention in recent years. The main widespread techniques to assemble small components (i.e., microbeads) into regular patterns are microstamping [1,2] and capillary- or template-based methods [3,4,5,6,7]. They have been used in several prospective applications such as photonic crystals [8], micro lens array [9], display of structured color [10], micro/nano lithography [11,12], and bio-separation/sensing [13,14].…”

Section: Introductionmentioning

confidence: 99%

Assembly of Microparticles to Patterned Trenches Using the Depletion Volume Effect

2019

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In this paper, we demonstrate that 20 μm microbeads can be preferentially assembled into substrate trenches of similar width by employing a polymer (depletant) that induces the depletion volume effect (depletion attraction). In previous works, we proved that this strategy is useful to assemble mesoscale parts in a site-specific manner. Here, we show that it is also applicable to assemble functional parts, such as fluorescent particles, into trenches engraved on the surface of two- and three-dimensional template components. A convenient advantage of this strategy is that it is independent of material properties for assembling mesoscale functional components into desired patterns.

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Patterning Reactive Microdomains inside Polydimethylsiloxane Microchannels by Trapping and Melting Functional Polymer Particles

Cited by 9 publications

References 26 publications

Super-resolution surface mapping using the trajectories of molecular probes

Super-resolution surface mapping using the trajectories of molecular probes

Environmentally friendly surface modification of PDMS using PEG polymer brush

Assembly of Microparticles to Patterned Trenches Using the Depletion Volume Effect

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