Patterns of Breast Lesions in Patients Attending Cims, Bilaspur, C. G.: A Retrospective Tertiary Hospital Based Study

Abstract

ABSTRACT:The present study is designed to find out frequency of various histological patterns of breast lesions in patients attending Chhattisgarh Institute of Medical Sciences (CIMS), a teaching institute in Bilaspur Chhattisgarh and their biopsy samples studied in department of pathology. A retrospective series study was conducted on 335 cases of breast lesions, reported from 2003 to 2014. Mean age of the subjects was 49.65 years with standard deviation 12.06 years, ranging from 12 to 75 years. In a total 335 cases, 40(11.94%) were non-neoplastic and 295(88.06%) were neoplastic. Among neoplastic lesions, 180(53.73%) were benign, 02(0.59%) borderline and 113(33.73%) found malignant. The commonest non-neoplastic lesion was fibrocystic disease of breast followed by fibroadenosis and sclerosing adenosis. Neoplastic lesions were more common than non-neoplastic lesions. Among histological types of breast tumours, fibroadenoma dominated the other types. Thus commonest benign tumour was fibroadenoma followed by phyllodes tumour and commonest malignant was infiltrating duct carcinoma followed by medullary carcinoma. The commonest borderline tumour was phyllodes tumour with borderline changes.

Study of expression and correlation of vascular endothelial growth factor with grading and staging of breast carcinoma

“…Breast carcinoma ranks first among the malignant tumours affecting females in many parts of the world (1) . A considerable body of research spanning almost three decades has documented that tumor growth and metastasis require persistent new blood vessel growth the absence of access to an adequate vasculature, tumor cells become necrotic and/or apoptotic restraining the increase in tumor volume that should result from continuous cell proliferation, the hallmark of cancer (2) .…”