“…The CRC measures quantify the strength of the association between the two physiological systems (i.e., the cardiac and respiratory systems) under the central autonomic control (Dick and Morris, 2004), and thus the resting level of CRC is largely associated with overall output of central autonomic network (CAN) (Peupelmann et al, 2009). In a recent study on the relationship between pharmacodynamics properties and CRC level, the changes in the CRC level was closely associated with the dose of central norepinephrine enhancer (Chang et al, 2012). By combining HRV with the respiratory rhythm, CRC can enhance the signal-to-noise ratio and be used to evaluate the intrinsic interactions among higher regulatory centers (Lalley, 2008;Peupelmann et al, 2009).…”