Patterns of Care and Outcome Analysis of Nasopharyngeal Carcinoma: An Indonesian Single Institution Study

Abstract

Background: Nasopharyngeal cancer is endemic to Southeast Asia. However, there is limited clinical evidence of nasopharyngeal cancer in Indonesia, which has the largest population in Southeast Asia. Methods: Patterns of care and treatment outcomes in 428 patients with newly-diagnosed and pathologically-confirmed nasopharyngeal cancer were retrospectively analyzed. Results: Concurrent chemo-radiotherapy (CCRT) was the first-line treatment for stages I-IVB diseases. The 2-year overall survival (OS) of all patients were 100.0%, 100.0%, 93.8%, 86.2%, 82.9%, and 62.4% for stages I, II, III, IVA, IVB, and IVC, respectively. The 2-year OS of CCRT-treated patients were 100.0%, 100.0%, 92.6%, 82.4%, and 78.3% for stages I, II, III, IVA, and IVB, respectively. Conclusion: The patterns of care and treatment outcomes were potentially consistent with world standards, needing future validation. This is the largest study of newly diagnosed nasopharyngeal cancer in Indonesia, a huge disease burden, providing an important basis for the clinical management of this disease.

In vitro Production of Dendritic Cells as Cancer Immunotherapy: Highlights on Sample Source, Culture Period, Differentiation and Maturation Cytokines

“…3 Despite it is commonly used as a treatment, chemoradiation may cause side effects such as fatigue, vomiting, nausea, dermatitis, stomatitis, diarrhea, weight loss, leukopenia, neutropenia, thrombocytopenia, anemia, and ototoxic. [4][5][6][7][8] The current goal of cancer treatment is to provide a target-specific immune system with high efficacy and safety, diminishing the chemoradiation effect. 9 DC have the potential to present antigens and mediating crosstalk between innate and adaptive immune responses through major histocompatibility complex (MHC).…”

Novel Prognostic Indicators of Long Noncoding RNA Somatostatin Receptor 5 Antisense RNA 1 and Tubulin Alpha 4B in Prognosis of Nasopharyngeal Carcinoma

“…Nasopharyngeal Carcinoma (NPC) is a malignant tumor occurring at the top and lateral wall of the nasopharynx [1] . As one of the most common malignancies in China, the incidence ranks first among all the otorhinolaryngology malignant tumors [2][3][4] . According to global cancer statistics, there are 133 354 new cases in the nasopharynx site and 80 008 NPCrelated deaths around the world in 2020 [5] .…”