Patterns of changes in fasting plasma glucose, hemoglobin A1c and the area under the curve during oral glucose tolerance tests in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

Safari, Shahla; Amini, Masoud; Aminorroaya, Ashraf; Feizi, Awat

doi:10.1007/s00592-020-01622-5

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…Findings from our study also confirm the benefit of using HbA1c in combination with FPG to estimate the progression rate of DM and classify patients with IFG to be high or low risk of DM. Our results corresponded to the findings from previous meta-analyses11 22 and cohort studies19 20 23 24 that patients with combined IFG and abnormal HbA1c had significantly higher risk of DM than patients with IFG alone. In addition to the prediction of DM risk, results from large prospective cohort studies23 25 found that pre-diabetes defined by HbA1c criteria conferred a significantly higher risk of CVDs, CKD and all-cause mortality.…”

Section: Discussionsupporting

confidence: 91%

Hemoglobin A1c in combination with fasting plasma glucose trumps fasting plasma glucose alone as predictive indicators for diabetes mellitus: an ambidirectional cohort study of Thai people with impaired fasting glucose

Thamakaison

Anothaisintawee

Sukhato

et al. 2021

BMJ Open Diab Res Care

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IntroductionThis ambidirectional cohort study aimed to assess the performance of combining hemoglobin A1c (HbA1c) to fasting plasma glucose (FPG) for estimation of progression rate to diabetes mellitus (DM) and to explore the risk factors of DM in patients with impaired fasting glucose (IFG).Research design and methodsPatients with IFG were eligible for this study. IFG was defined as FPG of 100–125 mg/dL. Progression rates to DM were estimated using Kaplan-Meier analysis. Risk factors of DM were explored by Cox regression analysis.Results3011 patients were enrolled with median follow-up time of 8 years (range: 6 months–29 years). Progression rates to DM in patients with FPG 100–109 mg/dL and 110–125 mg/dL were 2.64 and 4.79 per 100 person-years. After adjusting covariables, compared with patients with FPG 100–109 mg/dL plus normal HbA1c (<5.7%), hazard ratios (95% CI) of patients with FPG 110–125 plus normal HbA1c, FBG 100–109 plus abnormal HbA1c (5.7%–6.49%), and FPG 110–125 plus abnormal HbA1c were 5.89 (2.37 to 14.63), 16.30 (8.59 to 30.92), and 33.84 (16.41 to 69.78), respectively. Body mass index ≥27.5 kg/m2, serum triglyceride level ≥150 mg/dL, family history of DM, and low level of high-density lipoprotein-cholesterol were independently associated with risk of DM in patients with IFG.ConclusionsPatients with both IFG and abnormal HbA1c had higher risk of DM than patients with IFG alone. Therefore, performing HbA1c in combination with FPG helps to identify subgroups of people with IFG at highest risk of DM. These patients should have the highest priority in diabetes prevention programs, especially in countries with low and limited resources.

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Section: Discussionsupporting

confidence: 91%

Hemoglobin A1c in combination with fasting plasma glucose trumps fasting plasma glucose alone as predictive indicators for diabetes mellitus: an ambidirectional cohort study of Thai people with impaired fasting glucose

Thamakaison

Anothaisintawee

Sukhato

et al. 2021

BMJ Open Diab Res Care

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“…In previous studies, elder patients tended to show slower glucose and IRI responses with higher IRI values and glucose 2 hours after a meal [24]. Therefore, we analyzed AUC and ⊿AUC for glucose and IRI during 0-2h and analyzed several related data [23]. The result showed that the obtained distribution of M value was wider than the distribution of mean blood glucose, and then the difference can be clearly grasped [24].…”

Section: Discussionmentioning

confidence: 92%

“…For pathophysiological evaluation for glucose and IRI, the method of Area Under the Curve (AUC) has been used [21]. Glucose AUC can be measured and calculated by the multiplication of glucose value and time [22,23]. In the current study, data of glucose values are obtained 7 points from 0700h to 2100h, and the Glucose-AUC was calculated.…”

Section: Auc Studymentioning

confidence: 99%

Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

Takehisa¹,

Bando

2020

Diab Res Open Access

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Background: Authors and collaborators have continued medical practice in the Heisei Medical Welfare (HMW) group for long years for mainly two areas, extensive care for the elderly and diabetes research. From both of them, the current research was held on the daily profile of glucose and insulin for patients with type 2 diabetes mellitus (T2DM). Subjects and Methods: Cases were 6 T2DM patients in admission, with ages 67.5 ± 12.7 years, diabetes duration 9.5 years. Methods included a daily profile of glucose and insulin for seven times per day, Morbus (M) value, Meal Tolerance Test (MTT) using breakfast with 70g carbohydrate, insulinogenic index (IGI)-2 hours, various correlations among HbA1c, M value, Area Under the Curve (AUC) of glucose and insulin. Results: Cases showed average values of HbA1c 8.4 ± 0.7%, glucose 197 mg/dL, M value 111. Glucose and IRI levels increased during 0700-0900h with 154-258 mg/dL and 13.8-54.3 μU/ml. There was a significant correlation between Glucose-⊿AUC and M value (p<0.05). Discussion: Daily profile of glucose and insulin showed a similar manner, suggesting post-prandial glucose influence due to carbohydrate intake. When studied cases increase, significant correlations among M value, HbA1c and glucose-AUC seem to be found. This report hopefully becomes a reference for future diabetic research.

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“…Worldwide, a recent assessment showed that in 2006-2014 increasing trends of diabetes were reported in only 33% of populations, whereas 30% had stable and 36% a declining incidence [39]. Some population-based cohort studies of diabetes and IH applying repeat OGTTs have been previously published elsewhere [44][45][46][47][48][49][50] although recent studies and those having such a long, more than 20-years, follow-up are rare. The 10-year incidence of diabetes in people born 1935 in northern Finland was 17.1% as evaluated from 1996 to 2008 [41].…”

Section: Discussionmentioning

confidence: 99%

22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland

Saramies

Koiranen

Auvinen

et al. 2021

Primary Care Diabetes

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Patterns of changes in fasting plasma glucose, hemoglobin A1c and the area under the curve during oral glucose tolerance tests in prediabetic subjects: results from a 16-year prospective cohort study among first-degree relatives of type 2 diabetic patients

Cited by 4 publications

References 44 publications

Hemoglobin A1c in combination with fasting plasma glucose trumps fasting plasma glucose alone as predictive indicators for diabetes mellitus: an ambidirectional cohort study of Thai people with impaired fasting glucose

Hemoglobin A1c in combination with fasting plasma glucose trumps fasting plasma glucose alone as predictive indicators for diabetes mellitus: an ambidirectional cohort study of Thai people with impaired fasting glucose

Blood Glucose and Insulin Values on Daily Profile, M Value and Meal Tolerance in Patients with Type 2 Diabetes Mellitus (T2DM)

22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland

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