Patterns of disease among adults hospitalized with dengue infections

Malavige, Gathsaurie Neelika; Velathanthiri, V.G.N.S.; Wijewickrama, Eranga; Fernando, S.S.N.; Jayaratne, S D; Aaskov, John; Seneviratne, SL

doi:10.1093/qjmed/hcl039

Cited by 93 publications

(116 citation statements)

References 18 publications

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“…Similar to the results published in other papers, a higher percentage of women in our study were in their third trimester; and in contrast to a previous Sri Lankan study of dengue in pregnancy [20], our cohort showed that secondary infections were more common than primary (44% versus 62%). This pattern is similar to that of non-pregnant adults [5,29].…”

Section: Resultssupporting

confidence: 81%

“…In general, the most common symptoms include fever, myalgia and arthralgia [5]. Fluid leakage (elevated hematocrit, pleural effusion or ascites) and hemorrhagic manifestations are characteristic features of DHF.…”

Section: Resultsmentioning

confidence: 99%

“…Significant outbreaks of dengue occur every few years due to the presence of all four viral serotypes [4]. The predominant serotypes during the last few years were DENV-2 and DENV-3 [5]. Infection by one serotype produces lifelong immunity to that specific serotype but only a few months of immunity to the others [6].…”

Section: Introductionmentioning

confidence: 99%

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Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka

Kariyawasam¹,

Senanayake²

2010

J Infect Dev Ctries

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Introduction: Dengue is the most important mosquito-borne disease in Sri Lanka, leading to more than 340 deaths during the last outbreak (≈35,000 reported cases) starting in mid April 2009. The predominant dengue virus serotypes during the last few years have been DENV-2 and DENV-3. Dengue infection in pregnancy carries the risk of hemorrhage for both the mother and the newborn. Other risks include premature birth, fetal death, and vertical transmission. We report clinical and laboratory findings and outcomes in pregnant women hospitalized with dengue infection during pregnancy. Methodology: Clinical, laboratory, maternal/fetal outcomes and demographic data were collected from patients with confirmed dengue infections during pregnancy treated at De Soysa Maternity Hospital, Sri Lanka from 1 May 2009 to 31 December 2009. Results: Fifteen seropositive dengue infected pregnant women were diagnosed in the period. Multiorgan failure leading to intrauterine fetal and maternal death occurred in one case of dengue hemorrhagic fever (DHF) IV. One patient with DHF III had a miscarriage at the 24 th week of gestation. Perinatal outcomes of the other cases were satisfactory. One woman developed dengue myocarditis but recovered with supportive treatments. No cases of perinatal transmission to the neonate occurred. Conclusion: Dengue in pregnancy requires early diagnosis and treatment. A high index of clinical suspicion is essential in any pregnant woman with fever during epidemic. Further studies are mandatory as evidence-based data in the management of dengue specific for pregnancy are sparse.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

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Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka

Kariyawasam¹,

Senanayake²

2010

J Infect Dev Ctries

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“…Bleeding manifestation was not a common feature in our study, majority of the patients presented with fever, headache, myalgia and generalized rash except four cases who presented with DHF and two cases with DSS which correlates well with other authors [6]. But others had reported higher incidence of bleeding manifestations in their study [7,8]. The major diagnostic methods currently available are viral culture, viral RNA detection by RT-PCR and serological tests such as IgM capture ELISA.…”

Section: Discussionsupporting

confidence: 87%

NS1 Antigen Capture ELISA an Effective Method for Diagnosis of Early Dengue Infection - Report of an Outbreak at Angul District, Odisha, India

Mahapatra

Sarangi

Mahapatra

et al. 2014

JCDR

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“…Figure 1 shows the number of DHF cases and deaths since 1989 in Sri Lanka. The occurrence of the massive epidemic in year 2004 is thought to be due to yet another change in the predominant circulating virus serotype (from DEN-2 to DEN-3) 18,19 . DEN-3 was also the cause of the epidemics that occurred in India and other countries of the region during this period 20 .…”

Section: Dengue Viral Infections In Sri Lankamentioning

confidence: 99%

Emerging infectious diseases

Fernando¹,

Malavige²,

Karunaratne³

et al. 2008

J. Natn. Sci. Foundation Sri Lanka

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Emerging infections diseases (EIDs) cause a significant burden on the global economies and are a major public health problem in many countries. The incidence of EID has increased dramatically in recent years, mainly due to zoonotic infections. Sri Lanka has also been significantly affected by EIDs such as dengue, chikungunya and antibiotic resistant bacterial infections. Diseases such as leptospirosis, which have been present for many decades in Sri Lanka are now causing significant public health problems and have been associated with very high mortality. In addition, infections due to the avian influenza A (H5N1) strain, Severe Acute Respiratory Syndrome (SARS) virus and the Nipah virus are some of the pathogens which have a potential of causing severe epidemics in Sri Lanka in the future.As it is beyond the scope of this review to discuss all the current EIDs, it will mainly concentrate on EIDs that have recently caused major public health problems in Sri Lanka and also those that have a possibility of causing major epidemics.

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Patterns of disease among adults hospitalized with dengue infections

Cited by 93 publications

References 18 publications

Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka

Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka

NS1 Antigen Capture ELISA an Effective Method for Diagnosis of Early Dengue Infection - Report of an Outbreak at Angul District, Odisha, India

Emerging infectious diseases

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