Patterns of Dupuytren Disease in Fingers

Lanting, Rosanne; Nooraee, Nazanin; Werker, Paul M. N.; Heuvel, Edwin R. van den

doi:10.1097/prs.0000000000000429

Cited by 12 publications

(3 citation statements)

References 27 publications

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“…Gebereegziabher et al are the first to describe a substantial series of 75 Ethiopian cases of DD originating from various tribes living in various parts of the country, but seen in one hospital in Addis Ababa over the course of 2 years. The age distribution, as well as the phenotypical characteristics of DD in these cases are, in general, similar to those of a previously described (Caucasian) series (Lanting et al, 2014), except for the underrepresentation of symptoms in the left hand. Of note is the relatively high prevalence of hypertension found in this series, which has not been reported in Caucasian series, but has in a nation-wide population-based study in Taiwan (Yeh et al, 2015).…”

supporting

confidence: 85%

Commentary on Dupuytren’s contracture in Ethiopia. A. Gebereegziabher, A. Baraki, Y. Kebede, I. Mohammed and V. Finsen. J Hand Surg Eur. 2017, 42: 26–8.

Werker

2016

J Hand Surg Eur Vol

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supporting

confidence: 85%

Commentary on Dupuytren’s contracture in Ethiopia. A. Gebereegziabher, A. Baraki, Y. Kebede, I. Mohammed and V. Finsen. J Hand Surg Eur. 2017, 42: 26–8.

Werker

2016

J Hand Surg Eur Vol

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“…[ 2 ] Myofibroblasts differentiated from normal fibroblasts have been considered a cause of the flexion contractures. Because clinical investigations of Dupuytren disease have demonstrated a strong, unexplained predominance in men, with a male:female ratio of about 6:1 among Dupuytren disease patients, [ 3 ] and a predominance in the ulnar rays, that is, the fourth and fifth digits, [ 4 ] we developed a hypothesis that myofibroblast metabolism may be regulated by endogenous androgenic male hormones, which is also supported by the previous reports. Pagnotta et al [ 5 , 6 ] have shown that the palmar fascia of Dupuytren disease had higher expression of androgenic receptors than in those without Dupuytren disease, and that cultured fibroblasts from patients with Dupuytren disease were significantly differentiated into myofibroblasts by stimulation with androgens.…”

Section: Introductionsupporting

confidence: 67%

Low second to fourth digit ratio in Dupuytren disease

Yokoi

Uemura²,

Kazuki³

et al. 2017

Medicine

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The ratio of the lengths of the second and fourth digits (2D:4D) has been described as reflecting endogenous prenatal androgen exposure. In general, 2D:4D is lower in men than in women and has potential as a biomarker or predictor for various diseases, athletic ability, and academic performance. Dupuytren disease has digital flexion contractures and is known to predominate in men, but the pathogenesis of the disease remains unclear. To clarify the relationships between Dupuytren disease and endogenous androgens, we performed a retrospective analysis of hand radiographs to investigate 2D:4D in Dupuytren disease. The study included male patients with Dupuytren disease (n = 22) and a control group (n = 18) of male patients with carpal tunnel syndrome. Only unaffected hands, without contractures or osteoarthritis, were evaluated for the purpose of radiographic assessment. The lengths of the phalanx and metacarpal bones in the second and fourth digits were measured by 2 independent observers who each performed 2 sets of measurements separated by a minimum 1-week interval. The 2D:4D was calculated separately for the phalanges and metacarpals, and a combined (phalanx + metacarpal) 2D:4D was also calculated. The reliability of the observer measurements was established using the intraclass correlation coefficient, and both the intra- and interobserver reliability showed excellent agreement. We found that compared with control group, the Dupuytren disease group had significantly lower phalanx and combined 2D:4D. These findings suggest that endogenous prenatal androgens could contribute to the development of Dupuytren disease, leading to its characteristic clinical presentation predominantly in men and affecting the ulnar rays.

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“…Nodules can present in both the palm and fingers. The ring finger is most often affected, and then, in order of frequency, the small finger, thumb, middle finger, and index finger [ 2 ]. DD is commonly bilateral, and it can become both a physically and a psychosocially disabling condition that significantly affects healthcare resources [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological profile of Dupuytren’s disease in Taiwan (Ethnic Chinese): a nationwide population-based study

Yeh

Huang

et al. 2015

BMC Musculoskelet Disord

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BackgroundThe epidemiologic profile of ethnic Chinese patients with Dupuytren’s disease is unknown. We therefore investigated the epidemiology of Dupuytren’s disease using Taiwan’s National Health Insurance Research Database.MethodsPatients who filed claims for treatment for Dupuytren’s disease between January 2000 and December 2011 were identified in the database. Age- and gender-specific incidences were estimated by dividing the incidence number by population data.ResultsWe identified 1,078 patients with Dupuytren’s disease (681 men, 397 women; male/female ratio: 1:1.72). The annual incidence rate ranged from 0.39-0.63/105 for men and 0.14-0.44/105 for women. A trend analysis revealed a rising trend in the annual incidence from 2001 to 2011 (p = 0.0199). The prevalence rate increased steadily from 0.46/105 in 2000 to 4.52/105 in 2011 (p = 0.0186). The mean age at onset was significantly higher in men than in women (60.7 ± 18.4 vs. 53.7 ± 15.5 years). Peak age at onset for men was 70–79 (28.1%) and for women was 50–59 (33.5%). Men > 60 years old had higher incidence rates than did women (incidence rate ratios: 2.0, 4.5, and 6.6 for those 60–69, 70–79, and ≥ 80, respectively). Hypertension (29.6%), diabetes mellitus (21.9%), hyperlipidemia (14.8%), ischemic heart disease (10.5%), and chronic obstructive pulmonary disease (8.0%) were the most common comorbidities.ConclusionsThe incidence and prevalence of Dupuytren’s disease and the male/female ratio were significantly lower in ethnic Chinese than in Western ethnic groups. Moreover, the age at onset was significantly lower in ethnic Chinese women. However, the incidences of three comorbidities (hypertension, diabetes mellitus, and hyperlipidemia) were similar to those in other ethnicities.

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Patterns of Dupuytren Disease in Fingers

Abstract: Risk, III.

Cited by 12 publications

References 27 publications

Commentary on Dupuytren’s contracture in Ethiopia. A. Gebereegziabher, A. Baraki, Y. Kebede, I. Mohammed and V. Finsen. J Hand Surg Eur. 2017, 42: 26–8.

Commentary on Dupuytren’s contracture in Ethiopia. A. Gebereegziabher, A. Baraki, Y. Kebede, I. Mohammed and V. Finsen. J Hand Surg Eur. 2017, 42: 26–8.

Low second to fourth digit ratio in Dupuytren disease

Epidemiological profile of Dupuytren’s disease in Taiwan (Ethnic Chinese): a nationwide population-based study

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