2017
DOI: 10.3747/co.24.3551
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Patterns of Failure in Anaplastic and Differentiated Thyroid Carcinoma Treated with Intensity-Modulated Radiotherapy

Abstract: BackgroundThe radiotherapy (rt) volumes in anaplastic (atc) and differentiated thyroid carcinoma (dtc)

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Cited by 10 publications
(6 citation statements)
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“…This IMRT technique is important to deliver the optimal dose to the different treatment volumes which most often include the operative bed, the thyroid, and lymph node areas I to VI with the upper mediastinum up to the carina [ 63 , 78 , 79 , 89 , 95 ]. Few relapses at the edge of the radiotherapy field (less than 10% marginal relapses) have been reported [ 96 , 97 ]. The rate of loco-regional failure rate may relate to the extent of the EBRT field, as reported by Kim et al, with a five-year local control rate of 40% in ATC patients treated with a large extended field ( n = 12) (such as described before) vs. 9% in case of limited field EBRT ( n = 11) to involved site (tumor and node) ( p = 0.04).…”
Section: Treatment: To Treat Aggressively or To Palliate The Symptoms?mentioning
confidence: 99%
“…This IMRT technique is important to deliver the optimal dose to the different treatment volumes which most often include the operative bed, the thyroid, and lymph node areas I to VI with the upper mediastinum up to the carina [ 63 , 78 , 79 , 89 , 95 ]. Few relapses at the edge of the radiotherapy field (less than 10% marginal relapses) have been reported [ 96 , 97 ]. The rate of loco-regional failure rate may relate to the extent of the EBRT field, as reported by Kim et al, with a five-year local control rate of 40% in ATC patients treated with a large extended field ( n = 12) (such as described before) vs. 9% in case of limited field EBRT ( n = 11) to involved site (tumor and node) ( p = 0.04).…”
Section: Treatment: To Treat Aggressively or To Palliate The Symptoms?mentioning
confidence: 99%
“…Kim et al [14] ont aussi observé une réduction significative du risque de rechute locorégional de 27 % à 8 % en cas d'inclusion dans les volumes irradiés prophylactiquement du médiastin supérieur et des aires ganglionnaires cervicales non atteintes mais contiguës aux aires ganglionnaires atteintes, dans une cohorte rétrospective de 23 patients. À l'inverse, Vulpe et al [8] ont conduit une étude rétrospective sur 30 patients pour évaluer les lieux de rechutes après radiothérapie pour un carcinome thyroïde différencié. Parmi les 30 patients atteints d'un carcinome différencié de la thyroïde, quatre rechutes ont été observées, dont une seulement dans les volumes de traitement.…”
Section: Discussionunclassified
“…La radiothérapie cervicale trouve sa place pour le traitement des rechutes cervicales, mais comme une option dont la place est mal définie, avec peu de données d'efficacité en dehors de données rétrospectives, principalement dans un contexte postopératoire [6,7]. La place de la radiothérapie externe en rechute cervicale non résécable et réfractaire à l'iode est mal définie, elle est souvent proposée en dernier recours dans un objectif de contrôle de la maladie cervicale afin d'éviter notamment un syndrome de compression vasculaire ou des voies aérodigestives supérieures avec un faible niveau de preuve [6,[8][9][10][11][12]. L'objectif de cette cohorte est de rapporter la survie sans rechute locorégionale, la survie globale et la toxicité au décours d'une radiothérapie cervicale en situation de rechute cervicale de carcinomes différenciés de la thyroïde, en association ou non à une chimiothérapie concomitante.…”
Section: Introductionunclassified
“…The benefit of radiation in the setting of nonmetastatic ATC is thought to primarily stem from improved locoregional control. [11][12][13][14] A significant cause of morbidity and mortality in ATC is tumor invasion into, and obstruction of, the structures adjacent to the thyroid gland. The trachea and esophagus are particularly vulnerable to the effects of local tumor invasion, and death from airway obstruction or aspiration pneumonia is a serious concern in ATC.…”
Section: Discussionmentioning
confidence: 99%