Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumor

Paulino, Arnold C.; Daniel, Todd; Barker, Jerry L.; Lo, Simon S.; Manera, Ricarchito

doi:10.1016/j.ijrobp.2003.08.022

Cited by 24 publications

(15 citation statements)

References 18 publications

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“…Headache, vomiting, visual disturbance and ataxia were the common presenting features in our study cohort. SPNET shows a high propensity of CSF dissemination (14-20 %) [17,18]. In the present series, 3 patients had M3 and 1 patient had M1 disease at presentation.…”

Section: Survival Analysismentioning

confidence: 48%

“…Keeping in mind the natural history of the tumour, craniospinal irradiation (CSI) followed by local boost to tumour bed is considered standard [18]. The most commonly used time dose fractionation schedule is CSI to a dose of 36 Gy (range 18-40 Gy) followed by local boost to 54 Gy (range 45-72 Gy) in conventional fractionation (Table 3).…”

Section: Survival Analysismentioning

confidence: 99%

“…Reduced dose CSI (23.4 Gy) or focal RT alone has been used in very young children (1.5-3 years) in few studies to minimize the late effects of radiation (Table 3). Paulino et al in a series of 25 patients of SPNET reported 5-year and 10-year progression-free survival (PFS) rates of 47.1 % in patients treated with CSI compared to 12.5 and 0 % in patients undergoing whole brain RT (WBRT) or focal RT(P=0.02) [18]. Failure at untreated neuraxis site was the most common cause of progression in 6 out of 8 patients receiving WBRT or focal RT [18].…”

Section: Survival Analysismentioning

confidence: 99%

“…Paulino et al in a series of 25 patients of SPNET reported 5-year and 10-year progression-free survival (PFS) rates of 47.1 % in patients treated with CSI compared to 12.5 and 0 % in patients undergoing whole brain RT (WBRT) or focal RT(P=0.02) [18]. Failure at untreated neuraxis site was the most common cause of progression in 6 out of 8 patients receiving WBRT or focal RT [18]. McBride et al in a retrospective review of 15 patients of non-pineal SPNET observed a statistically significant difference in overall survival in patients who received upfront RT versus those who did not (P=0.048) [17].…”

Section: Survival Analysismentioning

confidence: 99%

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Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India

et al. 2015

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Maximal safe resection followed by craniospinal irradiation and systemic chemotherapy with 6 cycles of carboplatin-etoposide regimen is a reasonable treatment strategy in patients of pinealoblastoma more than 8 years of age in a developing nation. However, the same strategy is less effective in younger children and innovative study designs of intensification of post-operative treatment must be explored in this age group.

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Section: Survival Analysismentioning

confidence: 48%

Section: Survival Analysismentioning

confidence: 99%

Section: Survival Analysismentioning

confidence: 99%

Section: Survival Analysismentioning

confidence: 99%

See 2 more Smart Citations

Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India

et al. 2015

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“…Medulloblastomas are among the most lethal tumours in children, both because of their intracranial location and their high degree of invasiveness, one of the major predictors of poor outcome being leptomeningeal spread 36 . Because of the way in which tumour cells invade surrounding normal brain, their dissemination via the cerebrospinal fluid 37 , and their resultant spread distant to the site of the initial tumour, complete surgical resection often is not feasible.…”

Section: Discussionmentioning

confidence: 99%

Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness

Ranger¹,

McDonald²,

Maestro

2009

Can. j. neurol. sci.

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In children, brain cancers can be particularly devastating; and medulloblastoma (MB), a primitive tumour of neuroectodermal origin, is among the most common. Rare in adults [1][2][3][4][5] , these tumours generally account for between 20 and 40% of paediatric intracranial malignancies worldwide [6][7][8][9][10][11][12] , and have an incidence of approximately 1-7 per million, depending upon the population studied and how medulloblastoma and the base populations are defined 11,[13][14][15][16] . They are especially common among preschoolers 17,18 , even among infants who are less than 18 months-of-age 19,20 . Outcomes in paediatric medulloblastoma patients, relative to those with most other childhood malignancies, tend to be poor, with five-year survival rates in ABSTRACT: Objectives: Surgical resection and adjuvant radiation are mainstays of medulloblastoma (MB) patient management. We utilized a novel 3-dimensional assay to identify how (a) radiation, (b) excision of the primary tumour aggregate, and (c) both treatments combined influence MB cell invasiveness. Methods: Five MB cell lines (UW228-1, 2 and 3; Daoy, and Madsen) were implanted onto a 3-dimensional, type I collagen gel assay to assess tumour invasion distance over five days, in response to (1) needle-assisted excision of the central cell aggregate; (2) pre-exposure to single-dose and fractionated dose irradiation in doses from 6-25 and 8-24 Gy, respectively; and (3) excision plus either single-dose or fractionated radiation. Results: Within hours, individual MB cells detached from the surface of the cell aggregates and invaded the collagen matrix, to distances up to 1200 µm and at rates up to 300 µm daily. The UW228-1 cell line was less invasive than the other cell lines and was dropped from further analysis. In the four remaining lines, a dosedependent decline in tumour invasiveness was identified, both for single-dose and fractionated radiation, which achieved statistically decreased invasion distances at higher doses, especially of fractionated irradiation. Excision of the central tumour aggregate tended towards exerting a late effect on cell invasion, but exerted no significant influence on the radio-sensitivity of residual cells. Conclusions: Both single-dose and fractionated dose irradiation appear to inhibit MB cell invasiveness in a dose-dependent manner, whereas excision of the central cell aggregate exerts no effect on residual invading cells. RÉSUMÉ: Effets de l'excision chirurgicale et de l'irradiation sur le caractère envahissant du médulloblastome.Objectifs : La résection chirurgicale et la radiothérapie sont le traitement de base du médulloblastome (MB). Nous avons utilisé une nouvelle méthode d'analyse tridimensionnelle pour identifier comment l'irradiation, l'excision de la tumeur primaire et les deux traitements combinés influencent le caractère envahissant des cellules du MB. Méthodes : Cinq lignées cellulaires de MB (UW228-1, 2, 3, Daoy et Madsen) ont été implantées dans un gel de collagène de type I tridimensionnel pour évaluer la...

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Evaluating the positional uncertainty of intrafraction, adjacent fields, and daily setup with the BrainLAB ExacTrac system in patients who are receiving craniospinal irradiation

Duan

Zhou

Dai

et al. 2020

J Applied Clin Med Phys

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Purpose: To investigate the daily setup, interfraction motion, variability in the junction areas, and dosimetric effect in craniospinal irradiation (CSI) patients. Methods: Fifteen CSI patients who had undergone split-field IMRT were followed in the study. Previous, middle, and posttreatment, each target volume position was evaluated using the ExacTrac system. Interfraction and intrafraction motions, the margin of the junction in adjacent targets volumes, and the dosimetric effect of the longitudinal residual error were analyzed. Results: The lowest attainment rate within the tolerance of the initial setup error was 66.79% in six directions. The values of the initial error were within 15 mm (SD 4.5 mm) in the translation direction and 5°(SD 1.3°) in the rotation direction after the transposition of the treatment isocenter. With the guidance of the ExacTrac system, the interfraction and intrafraction residual errors were almost within the tolerance after correction, the margin of CTV-to-PCTV was in the range of target expansion criteria. The residual longitudinal errors resulted in only slight changes in the mean doses of PGTV and PCTV, while the maximum dose of the spinal cord increased by 16.1%. The patients did not exhibit any side-effects by the overall treatment during the follow-up period. Conclusions: Position correction is necessary after setup and the transposition of the treatment isocenter. Intra-fraction motion in the lateral direction should be monitored throughout treatment. The position errors in junction areas are almost within the tolerance after correction. The patients did not exhibit any side-effects by the overall treatment.

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Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumor

Cited by 24 publications

References 18 publications

Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India

Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India

Effects of Surgical Excision and Radiation on Medulloblastoma Cell Invasiveness

Evaluating the positional uncertainty of intrafraction, adjacent fields, and daily setup with the BrainLAB ExacTrac system in patients who are receiving craniospinal irradiation

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