Patterns of Gastric Emptying in Dysmotility-Like Dyspepsia

Bortolotti, Mauro; Bolondi, Luigi; Santi, Vittorio; Sarti, Paolo; Brunelli, Federico; Leggett, Barbara A.

doi:10.3109/00365529509093299

Cited by 42 publications

(30 citation statements)

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“…[21][22][23][24] Several studies have established that delayed gastric emptying is present in a subset of patients with unexplained dyspeptic symptoms [1][2][3][4][5][6][7][8][9][10][11][12] and most largescale studies found a relationship between the presence of delayed emptying and the dyspeptic symptom pattern. [10][11][12] These observations suggest a possible pathophysiological role for delayed gastric emptying in eliciting dyspeptic symptoms like fullness, nausea and vomiting.…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the study, the percentage of dyspeptic patients with delayed gastric emptying is ranging from 25% to 50%. [1][2][3][4][5][6][7][8][9][10][11][12] Most studies failed to find a relationship between delayed gastric emptying and symptom pattern, 1-9 but recent large-scale studies showed that patients with delayed gastric emptying for solids are more likely to report postprandial fullness, nausea and vomiting. [10][11][12] The relationship between symptom pattern and the presence of delayed emptying suggests a possible pathophysiological role for delayed gastric emptying in eliciting dyspeptic symptoms like fullness, nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of delaying gastric emptying on meal‐related symptoms in healthy subjects

Tack¹,

Coulie²,

Verbeke³

et al. 2006

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of delaying gastric emptying on meal‐related symptoms in healthy subjects

Tack¹,

Coulie²,

Verbeke³

et al. 2006

Aliment Pharmacol Ther

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“…This impaired accommodation results in disproportional volume distribution, with a larger than normal antral volume, but smaller fundus volume 65 . The degree of antral distension is related to the severity of functional dyspepsia symptoms 66 . In addition, patients with functional dyspepsia show impaired fundus accommodation in response to duodenal distension 67 .…”

Section: Gastroduodenal Motilitymentioning

confidence: 99%

Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

260

247

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| Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation. A genetic predisposition is probable but less evident than in other functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). Psychiatric comorbidity and psychopathological state and trait characteristics could also play a part, although they are not specific to functional dyspepsia and are less pronounced than in IBS. Possible differential diagnoses include Helicobacter pylori infection and peptic ulceration. Pharmacological therapy is mostly based on the subtype of functional dyspepsia, such as prokinetic and fundus-relaxing drugs for PDS and acid-suppressive drugs for EPS, whereas centrally active neuromodulators and herbal drugs play a minor part. Psychotherapy is effective only in a small subset of patients, whereas quality of life can be severely affected in nearly all patients. Future therapies might include novel compounds that attempt to treat the underlying gastric and duodenal inflammation. NATURE REVIEWS | DISEASE PRIMERS VOLUME 3 | ARTICLE NUMBER 17081 | 1 PRIMER © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .standard therapy for gastro -oesophageal reflux disease. Paediatric dyspeptic symptoms are being addressed in a separate classification effort 10 . This Primer covers functional dyspepsia in adults only, although we sporadically refer to paediatric functional dyspepsia when similarities exist. EpidemiologyThe population prevalence of functional dyspepsia is quite variable across the globe, with overall high numbers (10-40%) in Western countries and low numbers (5-30%) in Asia, independent of the respective functional dyspepsia definitions 11 . A large-scale health and nutrition survey from France 12 (which involved >35,000 people) identified that 15% of individuals had suspected functional dyspepsia, 28% had irritable bowel syndrome (IBS) and 6% had both. The population of patients who are affected by both IBS and functional dyspepsia has been reported to range between 10% and 27% in previous studies 13 and to approach 30% in popu lation samples; it could be even higher in specific populations 14,15 . This observation has given rise to the term 'overlap syndrome' (REF. 13), which calls into question the sensitivity and specificity of the Rome criteria, at least for IBS and functional dyspepsia. This argument is also supported by the observation that patients with functional dyspepsia m...

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“…The serial US measurements of the antral volume enables to assess two relevant aspects of the gastric function, i.e., the antral volume, which is the expression of antral distension and the final gastric emptying time. The former cannot be assessed with scintigraphy and the latter has been shown to be the variable that best correlates with the scintigraphic method and to discriminate patients with delayed gastric emptying from controls [30][31][32]42] . In the present study extra-GI symptoms were reported by 53.7% of the patients.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

Pallotta

Pezzotti²,

Calabrese³

et al. 2005

WJG

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Abstract Abstract Abstract AIM: Delayed gastric emptying and an enlarged fasting gastric antrum are common findings in functional dyspepsia but their relationship with gastrointestinal (GI), and the frequently associated extra-GI symptoms remains unclear. This study evaluated the relationship between GI and extra-GI symptoms, fasting antral volume and delayed gastric emptying in functional dyspepsia. METHODS:In 108 functional dyspeptic patients antral volume and gastric emptying were assessed with ultrasonography (US). Symptoms were assessed with standardized questionnaire. The association of symptoms and fasting antral volume with delayed gastric emptying was estimated with logistic regression analysis. RESULTS:Delayed gastric emptying was detected in 39.8% of the patients. Postprandial drowsiness (AOR 11.25; 95%CI 2.75-45.93), nausea (AOR 3.51; 95%CI 1.19-10.32), fasting antral volume (AOR 1.93; 95%CI 1.22-3.05), were significantly associated with delayed gastric emptying. Symptoms, mainly the extra-GI ones as postprandial drowsiness and nausea, combined with fasting antral volume predicted the modality of gastric emptying with a sensitivity and specificity of 78%. CONCLUSION:In functional dyspeptic patients, (1) an analysis of fasting antral volume and of symptoms can offer valuable indication on the modality of gastric emptying, and (2) it seems appropriate to inquire on postprandial drowsiness that showed the best correlation with delayed gastric emptying.

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Patterns of Gastric Emptying in Dysmotility-Like Dyspepsia

Cited by 42 publications

References 11 publications

Influence of delaying gastric emptying on meal‐related symptoms in healthy subjects

Influence of delaying gastric emptying on meal‐related symptoms in healthy subjects

Functional dyspepsia

Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

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