Patterns of HDV reinfection in liver transplantation

Ottobrelli, A.; Salizzoni, Mauro; Cornù, C.; Lamy, M; Rayer, J.; G, Otte; Grendele, M.; Galmarini, D.; Marinucci, G.; Smedile, A.; Recehia, S.; Rizzetto, Mario

doi:10.1016/0168-8278(89)90313-9

“…The that both HDV and HBV recurred. The active replication of HBV might have been responsible for the increased patho-most detailed follow-up of HDV-infected patients with active HBV replication is available from Ottobrelli et al 11 Five cases genesis of HDV, which could have lead to the fulminant recurrence with massive hepatic necrosis. with HDV infection had active HBV replication before transplantation, noted by the presence of HBcAg in the liver and/ Our experience with two patients is not sufficient to associate active HBV replication in HDV-infected patients with a or HBV-DNA in serum.…”

mentioning

confidence: 99%

“…infection and could sustain a chronic, asymptomatic infection after transplantation. 11 This was notable, because it was prePersistent HBV replication, in chronic HDV-infected patients, has been associated with a worse outcome and a higher viously assumed that an HDV infection was dependent on a simultaneous HBV infection. These isolated HDV reinfec-severity of liver disease, compared to HDV-infected patients without active HBV replication.…”

mentioning

confidence: 99%

Fulminant Hepatitis B Virus: Recurrence After Liver Transplantation in Two Patients Also Infected With Hepatitis Delta Virus

Marsman

¹

,

Wiesner

²

,

Batts

³

et al. 1997

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sulted in a decrease in HBV recurrence and improved Liver transplantation for hepatitis B virus (HBV)-resurvival after transplantation. 5 However, despite the use of lated liver disease is complicated by HBV recurrence HBIG, patients with active HBV replication still experienced and, consequently, poor patient and graft survival. Paa high recurrence of HBV infection after liver transplantatients transplanted for hepatitis delta virus (HDV)-retion. lated cirrhosis are reported to have a diminished inciAn interesting subgroup of HBV-infected patients are those dence of HBV recurrence and improved graft survival.who are also infected with hepatitis delta virust (HDV). Such However, only a few reported HDV-infected patients had patients are reported to have a decrease in HBV recurrence active HBV replicative disease before liver transplantaand better survival after transplantation. The multicenter tion. In our experience, we transplanted two HDV-instudy in Europe reported 32% HBV recurrence and 85% surfected patients, both of whom had active HBV replicavival rate 3 years after transplantation in patients also intion before liver transplantation. In one patient, fected with HDV. 1 Recently, an HBV recurrence of only 13% hepatitis B surface antigen (HBsAg) recurred four and a 5-year actuarial survival rate of 88% was reported for months after transplantation. Two months later, Hepatiliver transplantation in patients with HDV infection. 6 All tis Be antigen (HBeAg) and HBV-DNA became positive, patients were also negative for HBV-DNA at the time of and the patient died of fulminant recurrent hepatitis B transplant. It has been suggested that suppressed HBV repliand hepatitis delta. In the other patient, HBV persisted cation in patients with HDV infection plays a role in the after transplantation, and 2 months later the patient rediminished recurrence of HBV. Indeed, the number of HDVquired retransplantation for fulminant recurrent hepainfected patients who had active replication of HBV before titis B and hepatitis delta. With the second graft, the transplantation was quite small. 6 patient remained free of HBV infection for 1 year. ThereThe outcome of patients with HDV infection who have acafter, the patient experienced HBV recurrence with active HBV replication remains undefined. Therefore, we report tive replication and died of fulminant hepatitis B and the clinical course of the only two HDV-infected patients who delta recurrence. In the first case and in the second graft underwent liver transplantation at our center. Both patients of the second case, hepatitis B immunoglobulin (HBIG) had active HBV replication before transplantation, noted by immunoprophylaxis was administered in an attempt to the presence of both hepatitis-Be-antigen (HBeAg) and HBVprevent recurrence of HBV. The literature suggests that DNA. Three liver transplantations were performed in these an HDV infection inhibits the replication of HBV and two patients, and both died because of fulminant recurrence therefore plays a role in preventing the rec...

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“…The that both HDV and HBV recurred. The active replication of HBV might have been responsible for the increased pathomost detailed follow-up of HDV-infected patients with active HBV replication is available from Ottobrelli et al 11 Five cases genesis of HDV, which could have lead to the fulminant recurrence with massive hepatic necrosis. with HDV infection had active HBV replication before transplantation, noted by the presence of HBcAg in the liver and/ Our experience with two patients is not sufficient to associate active HBV replication in HDV-infected patients with a or HBV-DNA in serum.…”

mentioning

confidence: 99%

Fulminant hepatitis B virus: Recurrence after liver transplantation in two patients also infected with hepatitis delta virus

Marsman¹

1997

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sulted in a decrease in HBV recurrence and improved Liver transplantation for hepatitis B virus (HBV)-resurvival after transplantation. 5 However, despite the use of lated liver disease is complicated by HBV recurrence HBIG, patients with active HBV replication still experienced and, consequently, poor patient and graft survival. Paa high recurrence of HBV infection after liver transplantatients transplanted for hepatitis delta virus (HDV)-retion. lated cirrhosis are reported to have a diminished inciAn interesting subgroup of HBV-infected patients are those dence of HBV recurrence and improved graft survival.who are also infected with hepatitis delta virust (HDV). Such However, only a few reported HDV-infected patients had patients are reported to have a decrease in HBV recurrence active HBV replicative disease before liver transplantaand better survival after transplantation. The multicenter tion. In our experience, we transplanted two HDV-instudy in Europe reported 32% HBV recurrence and 85% surfected patients, both of whom had active HBV replicavival rate 3 years after transplantation in patients also intion before liver transplantation. In one patient, fected with HDV. 1 Recently, an HBV recurrence of only 13% hepatitis B surface antigen (HBsAg) recurred four and a 5-year actuarial survival rate of 88% was reported for months after transplantation. Two months later, Hepatiliver transplantation in patients with HDV infection. 6 All tis Be antigen (HBeAg) and HBV-DNA became positive, patients were also negative for HBV-DNA at the time of and the patient died of fulminant recurrent hepatitis B transplant. It has been suggested that suppressed HBV repliand hepatitis delta. In the other patient, HBV persisted cation in patients with HDV infection plays a role in the after transplantation, and 2 months later the patient rediminished recurrence of HBV. Indeed, the number of HDVquired retransplantation for fulminant recurrent hepainfected patients who had active replication of HBV before titis B and hepatitis delta. With the second graft, the transplantation was quite small. 6 patient remained free of HBV infection for 1 year. ThereThe outcome of patients with HDV infection who have acafter, the patient experienced HBV recurrence with active HBV replication remains undefined. Therefore, we report tive replication and died of fulminant hepatitis B and the clinical course of the only two HDV-infected patients who delta recurrence. In the first case and in the second graft underwent liver transplantation at our center. Both patients of the second case, hepatitis B immunoglobulin (HBIG) had active HBV replication before transplantation, noted by immunoprophylaxis was administered in an attempt to the presence of both hepatitis-Be-antigen (HBeAg) and HBVprevent recurrence of HBV. The literature suggests that DNA. Three liver transplantations were performed in these an HDV infection inhibits the replication of HBV and two patients, and both died because of fulminant recurrence therefore plays a role in preventing the rec...

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Hepatitis B virus replication modulates pathogenesis of hepatitis D virus in chronic hepatitis D

Smedile

¹

,

Rosina

²

,

Saracco

³

et al. 1991

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Hepatitis D virus and hepatitis B virus nucleic acids were detected by Northern and Southern blot hybridization in the sera and livers of 85 chronic carriers of HBsAg and anti-hepatitis D followed up for a mean of 10 yr. We identified three subsets of patients: 13 with hepatitis D virus and hepatitis B virus viremia, 53 with serum hepatitis D virus RNA, but without hepatitis B virus DNA and 19 negative for both nucleic acids. Genomic and subgenomic forms of hepatitis D virus RNA were detected only in patients with hepatitis D virus and hepatitis B virus viremia. Histological findings and disease activity at admission were comparable in the three groups of patients, but the outcome was significantly worse in patients with active replication of both viruses; two of them died of terminal liver failure and hepatocellular carcinoma developed in two; the remaining patients had an uneventful course. These results suggest that active hepatitis B virus replication represents an important previously unrecognized determinant of severe liver damage in patients with chronic hepatitis D virus infection. Since hepatitis B virus provides the means for hepatitis D virus secretion and release from infected cells, active hepatitis B virus multiplication favoring the spread of hepatitis D virus from cell to cell may increase the pathogenetic potential of the defective agent.

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Patterns of HDV reinfection in liver transplantation

Cited by 8 publications

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Fulminant Hepatitis B Virus: Recurrence After Liver Transplantation in Two Patients Also Infected With Hepatitis Delta Virus

Fulminant Hepatitis B Virus: Recurrence After Liver Transplantation in Two Patients Also Infected With Hepatitis Delta Virus

Fulminant hepatitis B virus: Recurrence after liver transplantation in two patients also infected with hepatitis delta virus

Hepatitis B virus replication modulates pathogenesis of hepatitis D virus in chronic hepatitis D

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