Patterns of IgE sensitization in house dust mite‐allergic patients: implications for allergen immunotherapy

Batard, Thierry; Baron‐Bodo, Véronique; Martelet, Armelle; Mignon, Maxime Le; Lemoine, P.; Jain, K.; Mariano, S.; Horiot, S.; Chabre, Henri; Harwanegg, Christian; Marquette, Christophe A.; Corgier, Benjamin P.; Soh, Wai Tuck; Satitsuksanoa, Pattraporn; Jacquet, Alain; Chew, Fook Tim; Nony, Emmanuel; Moingeon, Philippe

doi:10.1111/all.12796

Cited by 92 publications

(105 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This may explain why SC antigen injection resulted in elevation of both IgG and IgE. In addition, some parasites such as house dust mites attach onto the skin surface to eat the desquamated corneal layer or sebum [27]. They usually grab the hair shaft or epidermal layer surface and do not invade into the dermal region.…”

Section: Discussionmentioning

confidence: 99%

Intradermal Delivery of Antigens Enhances Specific IgG and Diminishes IgE Production: Potential Use for Vaccination and Allergy Immunotherapy

et al. 2016

View full text Add to dashboard Cite

Skin is protected by a tough but flexible multilayered barrier and is a front line for immune responses against invading particles. For many years now, skin has been a tissue where certain vaccines are injected for the prevention of infectious disease, however, the detailed mechanisms of the skin immune response are not yet well understood. Using thin and small injection needles, we carefully injected OVA into a restricted region of mouse skin, i.e., intradermal (ID), and examined the antibody response in comparison with subcutaneous (SC) injection or epicutaneous patch administration of OVA. Epicutaneous patches induced a high IgE response against OVA, but IgG production was low. High IgG production was induced by both ID and SC injection, moreover, ID injection induced higher IgG production without any adjutants. Furthermore, OVA-specific IgE production was diminished by ID injection. We found that ID injection could efficiently stimulate skin resident DCs, drive Th1-biased conditions and diminish IgE production. The ID injection response was regulated by Langerin+ dermal DCs, because OVA was taken up mainly by these cells and, after transiently deleting them, the IgE response was no longer diminished and IgG1 production was enhanced. We also tested whether ID injection might be an effective allergy treatment by attempting to inhibit ongoing IgE production in mice with experimentally induced high serum IgE levels. Multiple ID injections of OVA were shown to prevent elevation of serum OVA-specific IgE after repeated allergen challenge. In contrast, SC OVA injection could only transiently inhibit the OVA-specific IgE production. These findings indicated that ID injection results in higher induction of antigen-specific IgG, and thus may be useful for vaccine delivery with little or no adjuvant components. Moreover, the observed diminishment of IgE and induction of Th1-biased immune responses suggest that ID may be a useful injection route for allergy immunotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Intradermal Delivery of Antigens Enhances Specific IgG and Diminishes IgE Production: Potential Use for Vaccination and Allergy Immunotherapy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…group 1, group 2 and group 23 allergens, are immunodominant based on the prevalence and magnitude of IgE responses determined by gravimetric estimations or comparative titrations with proteins of known allergenicity [22–26]. Using these criteria, the group 4, 5, 7 and 21 allergens exhibit medium or mid-tier allergenicity [22, 24–27] and the other groups minor or unknown allergenicity [15, 24, 25].…”

Section: Mite Allergensmentioning

confidence: 99%

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Sánchez‐Borges

Fernández-Caldas

Thomas

et al. 2017

World Allergy Organization Journal

View full text Add to dashboard Cite

Since mite allergens are the most relevant inducers of allergic diseases worldwide, resulting in significant morbidity and increased burden on health services, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), formed by the American Academy of Allergy, Asthma and Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO), has proposed to issue an International Consensus (ICON) on the clinical consequences of mite hypersensitivity. The objectives of this document are to highlight aspects of mite biology that are clinically relevant, to update the current knowledge on mite allergens, routes of sensitization, the genetics of IgE responses to mites, the epidemiologic aspects of mite hypersensitivity, the clinical pictures induced by mites, the diagnosis, specific immunotherapeutic approaches, and prevention.

show abstract

“…9 A limitation of this protocol is that these studies were performed with whole mite extract in order to sample the maximum number of RNA transcripts and proteins for stability assays. Since allergens are found in both whole bodies and fecal pellets, 10 human exposures are at least partially represented in the whole body extracts used here. Future studies will attempt to quantify the amount of DP proteins in dust mite fecal particles and samples of house dust to better compare the allergens and non-allergens to which humans are exposed.…”

Section: To the Editormentioning

confidence: 99%

Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?

Ogburn

Randall

et al. 2017

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

Patterns of IgE sensitization in house dust mite‐allergic patients: implications for allergen immunotherapy

Abstract: Mite-specific AIT should rely upon a mixture of D. pteronyssinus and D. farinae extracts, manufactured from both feces and bodies. Such a combination is appropriate to treat children and adult Dermatophagoides-allergic patients from Asia, Europe, and North America.

Cited by 92 publications

References 39 publications

Intradermal Delivery of Antigens Enhances Specific IgG and Diminishes IgE Production: Potential Use for Vaccination and Allergy Immunotherapy

Intradermal Delivery of Antigens Enhances Specific IgG and Diminishes IgE Production: Potential Use for Vaccination and Allergy Immunotherapy

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?

Contact Info

Product

Resources

About