2007
DOI: 10.1016/j.jss.2007.05.033
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Patterns of Kinase Activation Induced by Injury in the Murine Femoral Artery

Abstract: Background-Intimal hyperplasia remains the principal lesion in the development of restenosis after vessel wall injury. Cell signaling in vascular smooth muscle cells remains a potential molecular target to modulate the development of intimal hyperplasia. The aim of this study is to define a baseline pattern of histological changes and kinase activation in a murine model.

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Cited by 19 publications
(35 citation statements)
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“…Endoluminal injury to the common femoral artery was produced by three passages of a 0.25-mm-diameter angioplasty guidewire (Advanced Cardiovascular Systems, Santa Clara, CA) as previously described [3]. Control sham-operated arteries underwent dissection, temporary clamping, arteriotomy, and ligature, without passage of the wire.…”
Section: Femoral Wire Injurymentioning
confidence: 99%
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“…Endoluminal injury to the common femoral artery was produced by three passages of a 0.25-mm-diameter angioplasty guidewire (Advanced Cardiovascular Systems, Santa Clara, CA) as previously described [3]. Control sham-operated arteries underwent dissection, temporary clamping, arteriotomy, and ligature, without passage of the wire.…”
Section: Femoral Wire Injurymentioning
confidence: 99%
“…The vessels were harvested for Western blotting to detect peak gelatinase expression and activity and final morphometry. Pluronic gel (1 mL of 30% F127 Pluronic gel; Sigma, St. Louis, MO) was applied to the external surface of the femoral artery at the end of the procedure as previously described [3,8,9]. The pluronic gel remains in a liquid form at 4°C and rapidly forms a gel on exposure to body temperature.…”
Section: Femoral Wire Injurymentioning
confidence: 99%
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