Patterns of Positive and Negative Symptoms in First Episode Schizophrenia

Vázquez‐Barquero, José Luís; Lastra, I.; Núñez, Marta; Castanedo, S. Herrera; Dunn, Graham

doi:10.1192/bjp.168.6.693

Cited by 67 publications

(42 citation statements)

References 21 publications

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“…[12, 28, 43]. We have found delusions to load on to three factors; bizarre delusions loading with the disorganisation symptoms; mood congruent delusions with the affective dimensions and finally persecutory and systematised delusions loading on a discrete dimension; suggesting potentially different underlying psychopathological mechanisms for different forms of delusion.…”

Section: Discussionmentioning

confidence: 87%

Do symptom dimensions or categorical diagnoses best discriminate between known risk factors for psychosis?

Allardyce

McCreadie

Morrison

et al. 2007

Soc Psychiat Epidemiol

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j Abstract Objective To describe symptom dimensions of psychosis using detailed psychopathological information from epidemiologically defined incident cases which include the full spectrum of functional psychosis across all age ranges. Then, assess the comparative usefulness of the dimensional and categorical representations of psychosis in discriminating between demographic and pre-morbid risk factors. Method A total of 464 incident cases of psychosis assessed with OPCRIT (Operational Checklist for Psychotic Symptoms) were included in an exploratory factor analysis. Using Regression analyses we modelled the associations of the dimensional and categorical representations of psychosis with antecedent validating variables and compared the subsequent models using the likelihood ratio test. Results Factor analysis produced five-symptom dimensions, manic, disorganisation, depressive, delusional and auditory hallucinatory symptoms, explaining 58% of the total variance. Different dimensions were differentially associated with the pre-morbid risk factors. Neither the dimensional nor the categorical representations on their own were sufficient to explain associations with the antecedent validating variables. Conclusion Neither the dimensional or the diagnostic representation of psychosis was superior in discriminating between known risk factors, combining dimensional measures with categorical diagnoses will probably be more informative in determining the causes and correlates of psychosis.j Key words first episode psychosis -exploratory factor analyses -dimensions -classification systems -premorbid risk factors

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Section: Discussionmentioning

confidence: 87%

Do symptom dimensions or categorical diagnoses best discriminate between known risk factors for psychosis?

Allardyce

McCreadie

Morrison

et al. 2007

Soc Psychiat Epidemiol

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“…Vázquez-Barquero et al 1996 ;Peralta & Cuesta, 1999). Nevertheless, from such reports of positive psychotic symptoms, it would seem likely that paranoia is associated with youth, single marital status, urban dwelling, migrant status, low socio-economic status and emotional disorders (e.g.…”

Section: Introductionmentioning

confidence: 91%

Concomitants of paranoia in the general population

McManus²,

et al. 2010

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“…Despite their longevity of use, the diagnoses may prove an obstacle in the advancement of the understanding and treatment of the difficult experiences for which patients require help. The empirical research indicates that within these diagnoses are multiple independent experiences, such as paranoia, hallucinations, grandiosity, thought disorder, and anhedonia [13, 20–22]. A research approach, particularly adopted by cognitive psychology, has been to try to explain these single psychotic experiences.…”

Section: Introductionmentioning

confidence: 99%

Advances in understanding and treating persecutory delusions: a review

Freeman

Garety

2014

Soc Psychiatry Psychiatr Epidemiol

312

261

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PurposePersecutory delusions are a central psychotic experience, at the severe end of a paranoia spectrum in the general population. The aim of the review is to provide an introduction to the understanding of persecutory delusions, highlight key putative causal factors that have the potential to be translated into efficacious treatment, and indicate future research directions.MethodsA narrative literature review was undertaken to highlight the main recent areas of empirical study concerning non-clinical and clinical paranoia.ResultsSix main proximal causal factors are identified: a worry thinking style, negative beliefs about the self, interpersonal sensitivity, sleep disturbance, anomalous internal experience, and reasoning biases. Each has plausible mechanistic links to the occurrence of paranoia. These causal factors may be influenced by a number of social circumstances, including adverse events, illicit drug use, and urban environments.ConclusionsThere have been numerous replicated empirical findings leading to a significant advance in the understanding of persecutory delusions, now beginning to be translated into cognitive treatments. The first trials specifically focussed on patients who have persecutory delusions in the context of psychotic diagnoses are occurring. Initial evidence of efficacy is very promising.

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Patterns of Positive and Negative Symptoms in First Episode Schizophrenia

Abstract: The psychopathological structure of the early stages of schizophrenia, as evaluated by the SANS/SAPS, is characterised by the presence of four dimensions: two 'positive', one 'negative' and one 'disorganisation'.

Cited by 67 publications

References 21 publications

Do symptom dimensions or categorical diagnoses best discriminate between known risk factors for psychosis?

Do symptom dimensions or categorical diagnoses best discriminate between known risk factors for psychosis?

Concomitants of paranoia in the general population

Advances in understanding and treating persecutory delusions: a review

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