Patterns of Prostatic Intraepithelial Neoplasia

Abstract

BACKGROUND Prostatic intraepithelial neoplasia (PIN) remains as a well-known precancerous condition. Identification in biopsy specimen warrants repeat biopsy for subsequent carcinoma. The main aim of the study is to describe the morphological spectrum of prostatic intraepithelial neoplasia (PIN), its relationship to carcinoma of the prostate and its clinical significance. MATERIALS AND METHODS This is a descriptive study. Patients who were diagnosed clinically as benign prostatic hyperplasia (BPH) with symptoms of obstruction (hesitancy, poor flow, intermittent stream, dribbling) were included. Sections of the TURP chips were reviewed retrospectively in the Department of Pathology, Siddhartha Medical College, Vijayawada. A total of 75 cases were studied during a period of 2 years (October 2015 to November 2017) from the age group between 40-90 years. RESULTS 75 cases of TURP specimens were studied. Majority of cases are PIN, 43 cases (58%). All PIN cases were graded into 22 cases of low-grade PIN (LGPIN) (51%) and 21 cases of high-grade PIN (HGPIN) (49%). HGPIN shows marked nuclear enlargement, prominent eosinophilic nucleoli and increased chromatin compared to low-grade PIN. Majority of HGPIN cases in our study were noted in 60-69 yrs. constituting about 30 cases. CONCLUSION As prostatic intraepithelial neoplasia is a precursor lesion for prostatic carcinoma, it needs to be detected as early as possible. Prostatic biopsy helps to identify and treat the patients with high-grade PIN as well as carcinoma.