Introduction: Primary root canal treatment success depends on a number of variables, including debridement and disinfection of the root canal system to remove all bacteria and diseased pulpal and dentinal tissues. Complex root canal anatomy, such as concealed isthmuses, apical deltas and lateral canals, hinder this objective, making instrumentation of these regions nearly impossible. Recent advancements within the endodontic space have focused on improved cleaning and disinfection techniques that will enhance cleaning and debridement, even in difficult to navigate anatomy within the apical third.