2023
DOI: 10.1128/spectrum.03038-22
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PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability

Abstract: The growing problem of antibiotic resistance in Gram-negative pathogens is linked to three key aspects, (i) the progressive worldwide epidemic spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) Gram-negative strains, (ii) a decrease in the number of effective new antibiotics against multiresistant isolates, and (iii) the lack of mechanistically informed combinations and dosing strategies. Our combined efforts should focus not only on the development of new antimi… Show more

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Cited by 9 publications
(13 citation statements)
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“…However, the number of colistin-resistant (COL-R) bacteria is also increasing. The appearance of COL-R GNB has been frequently reported, signifying the failure of the last-resort agents to defeat drug-resistant GNB. , New antimicrobial agents to deal with this situation are urgently needed at this time. , …”
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confidence: 99%
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“…However, the number of colistin-resistant (COL-R) bacteria is also increasing. The appearance of COL-R GNB has been frequently reported, signifying the failure of the last-resort agents to defeat drug-resistant GNB. , New antimicrobial agents to deal with this situation are urgently needed at this time. , …”
mentioning
confidence: 99%
“…2,3 Based on their resistance characteristics toward antibiotics in the course of clinical treatment, drug-resistant pathogens are classified as multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria. 4,5 A pathogen that is nonsusceptible to at least one agent in three or more antimicrobial categories is considered MDR. A pathogen that is nonsusceptible to at least one agent in all but two or fewer categories is considered XDR, whereas a PDR bacterium exhibits resistance to all of the tested clinical antibiotics.…”
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confidence: 99%
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