PCB and chlorinated pesticide concentrations in swine and bovine adipose tissue in Sweden 1991–1997: spatial and temporal trends

Glynn, Anders; Wernroth, Lisa; Atuma, Samuel; Linder, Carl-Eric; Aune, Marie; Nilsson, Ingrid; Darnerud, Per Ola

doi:10.1016/s0048-9697(99)00458-1

Cited by 43 publications

(2 citation statements)

References 20 publications

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“…CB-153 is a well-established biomarker for PCB exposure and represents ∼25% of total PCB ( , ), suggesting a total PCB concentration in serum of 280−2500 ng/g fat in the present cohort. OH-PCB levels have been reported to constitute between 5% and 40% of the total PCB on a fat basis ( 23 , 35 , 40 , 41 ).…”

Section: Discussionmentioning

confidence: 73%

Hydroxy-PCBs, PBDEs, and HBCDDs in Serum from an Elderly Population of Swedish Fishermen's Wives and Associations with Bone Density

Weiss

Wallin

Axmon

et al. 2006

Environ. Sci. Technol.

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Lack of human exposure data is frequently reported as a critical gap in risk assessments of environmental pollutants, especially regarding "new" pollutants. The objectives of this study were to assess serum levels of the persistent 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153), hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecanes (HBCDDs) in a group of Swedish middle-aged and elderly women expected to be relatively highly exposed, and to evaluate the impact of potential determinants (e.g., fish intake, age) for the inter-individual variation, as well as to investigate the association between these pollutants and bone density. No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants. Relatively high levels of CB-153 (median 260 ng/g fat) and Σ 3 -OH-PCBs (median 1.7 ng/mL serum), and low concentrations of Σ 6 PBDEs (median 3.6 ng/g fat) were determined. Total level of HBCDDs in serum was quantified by gas chromatography with mass spectrometric detection (median 0.5 ng/g fat). HBCDD diastereomeric and enantiomeric patterns were determined by liquid chromatography with mass spectrometric detection. The dominating stereoisomer was (-)R-HBCDD, but 1-3% of γ-HBCDD was also detected in the serum samples.

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Section: Discussionmentioning

confidence: 73%

Hydroxy-PCBs, PBDEs, and HBCDDs in Serum from an Elderly Population of Swedish Fishermen's Wives and Associations with Bone Density

Weiss

Wallin

Axmon

et al. 2006

Environ. Sci. Technol.

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“…Using the environmental contamination scenario, the model predicted the PCB concentrations as a function of time in each of the trophic levels. The model predictions were compared with measurements in biota from the study area: Herring and cod from the Baltic Proper (IVL database, http://www.ivl.se/miljo/db/intro.asp), dairy products from Sweden and Denmark [73], Swedish beef [74], and Swedish human milk [75]. The results are illustrated in Figures 2 and 3 and discussed for each trophic level in the following sections.…”

Section: Resultsmentioning

confidence: 99%

A food chain model to predict the levels of lipophilic organic contaminants in humans

Czub

McLachlan

2004

Enviro Toxic and Chemistry

131

147

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A fugacity-based, nonsteady state, mechanistic model called ACC-HUMAN was developed to describe bioaccumulation of lipophilic organic pollutants from air, water, and soil to humans. The physical environment was linked via a marine and an agricultural food chain model to a human bioaccumulation model. Contaminant uptake via the primary dietary sources of persistent lipophilic contaminants in industrialized countries was addressed, namely fish, dairy products, and beef. In addition, uptake from air and water was considered, allowing the model also to treat less lipophilic compounds. To evaluate the model, the food chain characteristics were parameterized for southern Sweden and historical scenarios of polychlorinated biphenyl (PCB) concentrations in air, water, and soil in this region were constructed from published data. The resulting model predictions of PCB concentrations in fish, milk, beef, and human tissue agreed well with measured concentrations from Swedish monitoring programs. This suggests that ACC-HUMAN is a useful tool for predicting human exposure to bioaccumulative organic compounds. It can be linked easily to existing multimedia fate and transport models.

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Occurrence of PCBs, Organochlorine Insecticides, tris(4-Chlorophenyl)methane, and tris(4-Chlorophenyl)methanol in Human Breast Milk Collected from Cambodia

Kunisue

Someya

Monirith

et al. 2004

Arch Environ Contam Toxicol

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The present study determined the concentrations of persistent organochlorines (OCs) such as DDT and its metabolites (DDTs), polychlorinated biphenyls (PCBs), hexachlorocyclohexane isomers (HCHs), hexachlorobenzene (HCB), chlordane compounds (CHLs), tris(4-chlorophenyl)methane (TCPMe), and tris(4-chlorophenyl)methanol (TCPMOH) in human breast milk from Cambodia. DDTs, PCBs, HCHs, HCB, CHLs, and TCPMe were detected in almost all the human breast milk samples analyzed, and the concentrations ranged from 310 to 11,000, 6.0 to 87, <0.12 to 21, <0.12 to 8.1, <0.12 to 5.3, and 2.9 to 70 ng/g lipid wt, respectively. TCPMOH was detected in only 10 among 36 samples. Concentrations of DDTs in human breast milk from Cambodia were notably higher than those from developed countries and comparable to those from other developing countries, where usage of DDT for agricultural and public health purposes has been suspected to be continuing still, implying the recent usage of DDT in Cambodia. On the other hand, concentrations of PCBs, HCHs, HCB, and CHLs in human breast milk from Cambodia were 1-2 orders of magnitude less than those from other countries, indicating that Cambodia is one of the less contaminated countries by these OCs. Significant correlation between concentrations of TCPMe and DDTs in human breast milk suggested that exposure to DDT is the source of TCPMe in Cambodian residents. Concentrations of OCs in human breast milk tended to decrease with an increase in the number of children, implying that the first infant would be exposed to higher levels of OCs from breast milk and might be at higher risk by these contaminants, especially DDTs in Cambodia. To our knowledge, this is the first comprehensive study on the residue levels of OCs in human breast milk from Cambodia.

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PCB and chlorinated pesticide concentrations in swine and bovine adipose tissue in Sweden 1991–1997: spatial and temporal trends

Cited by 43 publications

References 20 publications

Hydroxy-PCBs, PBDEs, and HBCDDs in Serum from an Elderly Population of Swedish Fishermen's Wives and Associations with Bone Density

Hydroxy-PCBs, PBDEs, and HBCDDs in Serum from an Elderly Population of Swedish Fishermen's Wives and Associations with Bone Density

A food chain model to predict the levels of lipophilic organic contaminants in humans

Occurrence of PCBs, Organochlorine Insecticides, tris(4-Chlorophenyl)methane, and tris(4-Chlorophenyl)methanol in Human Breast Milk Collected from Cambodia

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