Pcn110 - Costs Associated With Trachea, Bronchus and Lung Cancer in Russia in 2016 Year

Abstract

The aim of the study is to determine the correlates of in-hospital costs for palliative care in a university hospital setting. METHODS: This is a retrospective cost-of-illness study using data from the records of patients who were admitted to Katip Celebi University Hospital during December 2013-December 2015. Direct medical costs were calculated from the Social Security Institute perspective. Socio-demographic and clinical information was abstracted from patient files. A generalized linear model was used in the multivariate analysis to generate cost ratios(CR). The average exchange rate for USD/TL was 2.72 for year 2015. RESULTS: We included 374 in-patients in total in the study. Gastrointestinal system cancers were the most common cancer type (42.4%) followed by genitourinary system cancers (20.1%), central nervous system (16.4%), breast cancer (10,7%) respectively. Neurologic cancers (4746±3989 TL) and genitourinary system cancers (3968±3804 TL) had the highest costs. The largest proportion of the total cost was formed by medical interventions (55.8%), followed by medications (17.0%). Radiotherapy CR:1.67(95%

Cyano Enone-Bearing Triterpenoid Soloxolone Methyl Inhibits Epithelial-Mesenchymal Transition of Human Lung Adenocarcinoma Cells In Vitro and Metastasis of Murine Melanoma In Vivo

“…Lung cancer is the most widespread and deadliest cancer worldwide, accounting for more than 14 million new cases and more than 1.6 million deaths annually [ 59 ]. In Russia, respiratory organs cancer is the most common type of oncologic diseases—according to Avxentyeva et al, in total, 185,631 patients were diagnosed with trachea, bronchus and lung cancer in 2016 in Russia with 51,769 incident cases and 51,476 deaths [ 60 ]. The one of the important cause of such high mortality of patients, along with the late diagnosis, is the lack of drugs, being able to effectively block signals from tumor microenvironment, which stimulate motility, invasion and dissemination of tumor cells from the primary site to distant organs due to induction of epithelial-mesenchymal transition (EMT), leading to an acquisition of mesenchymal-like highly invasive phenotype by malignant cells [ 1 , 2 , 5 ].…”