Pcn161 Risk of Venous Thromboembolism Associated With Initiation of Chemo-Immunotherapy Among Older Patients With Non-Hodgkin Lymphoma: Differences by Race and Subtype

Abstract

median age of patients with MCID was higher than those without MCID. Compared to patients without MCID, a higher proportion of patients that developed MCID were women, non-white, and had a Charlson score $ 2 at NHL diagnosis. Similar proportions of patients with and without MCID received treatment with chemoimmunotherapy. In unadjusted Fine-Gray regression models, exposure to any chemo-immunotherapy was associated with a null risk of MCID (sHR: 1.01; 95% CI: 0.77-1.33); findings were similar in multivariable models (sHR: 0.77, 95% CI: 0.57, 1.03) adjusting for potential confounders. In stratified analyses, chemo-immunotherapy exposure was consistently associated with a decreased risk of MCID regardless of age groups, race, or lymphoma subtype. Conclusions: This study suggests chemo-immunotherapy exposure in older patients with NHL is not associated with an increased risk of MCID.