PCOLCE Is Potent Prognostic Biomarker and Associates With Immune Infiltration in Gastric Cancer

Abstract

BackgroundThe exact biological role of PCOLCE was not yet clear and there were few reports study the correlation of PCOLCE gene expression level with the occurrence and development of gastric cancer.MethodsThe expression of PCOLCE was analyzed by performing the Oncomine and Ualcan database. We evaluated the function of PCOLCE on clinical prognosis with the use of Kaplan–Meier plotter database. The relationship between PCOLCE and cancer immune in filtrates was researched by Tumor Immune Estimation Resource (TIMER) site database.ResultsPCOLCE significantly upregulated in gastric cancer patients compared to normal gastric samples. And the increased expression of PCOLCE mRNA was closely linked to shorter overall survival (OS), progress-free survival (PFS) in all gastric cancers. Besides, PCOLCE expression displayed a tight correlation with infiltrating levels of macrophages and dendritic cells (DCs) in gastric cancer. Moreover, PCOLCE expression was positively correlated with diverse immune marker sets in gastric cancer.ConclusionAll the results above suggested that overexpression of PCOLCE indicated unfavorable prognosis in patients with gastric cancer. PCOLCE was correlated with immune infiltrating levels including those of B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and DCs in gastric cancer patients. All the findings suggested that PCOLCE could be used as a prognostic biomarker for determining prognosis and immune infiltration in gastric cancer. Additionally, PCOLCE expression potentially contributed to the regulation of monocyte, M2 macrophage, Tfh, CD8 + T cell, TAM, Th1 cell Thus PCOLCE is a potential target for gastric cancer therapy and these preliminary findings require further study to determine whether PCOLCE-targeting reagents might be developed for clinical application in gastric cancer.

Procollagen C-protease enhancer protein is a prognostic factor for glioma and promotes glioma development by regulating multiple tumor-related pathways and immune microenvironment

“…Xiang and his team reported that PCOLCE was elevated in gastric cancer and was associated with poor prognosis of gastric cancer patients. 11 The same study also revealed that PCOLCE expression was positively correlated with the level of dendritic cells and macrophages in the tumor microenvironment.…”

“…A recent study revealed that high expression of PCOLCE affected lymph node metastasis and was associated with poor prognosis in ovarian and gastric cancer. 11 Wang reported that PCOLCE expression was elevated by TWIST1 in osteosarcoma, and identified the N-glycosylation of PCOLCE as a critical promoter of metastasis of osteosarcoma. 10 This research is the first to systematically assess the roles and mechanisms of PCOLCE in glioma.…”

Identification and Verification of Potential Biomarkers in Gastric Cancer By Integrated Bioinformatic Analysis

“…Tumor-associated neutrophils (TANs) were proposed to induce lymphangiogenesis and angiogenesis, and it was shown that local infiltration of certain types of TANs may play a role in the metastasis in GC (Hiramatsu et al, 2018). Infiltration of dendritic cells in gastric cancer and lymph nodes of GC patients are well known (Tsujitani et al, 1992;Tsujitani et al, 1995), and its infiltrating level in GC was also found to be closely correlated with macrophage infiltration (Xiang et al, 2020). One study found that higher level of dendritic cell infiltration was associated with longer OS (Higgins and Thompson, 2002;Hu et al, 2014).…”

TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer

“…In addition, it has been reported that in ltration of M 0 macrophages predicts worse OS in LUAD patients 39 . Xiang et al have con rmed that PCOLCE could become a potent prognostic biomarker due to its association with the in ltrating TAM in gastric cancer 40 . Accumulating evidence suggests that the recruitment of Treg helps cancer cells to immune escape through various mechanisms 41 , and Treg accumulation could predict worse prognosis in several tumors of epithelial origin [42][43][44] .…”