PCR in herpes simplex virus infections of the central nervous system

Boerman, R.H.; Arnoldus, E. P. J.; Bloem, Bastiaan R.; Raap, A. K.; Peters, A. C. B.

doi:10.1016/0888-0786(94)90029-9

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…A PCR on CSF in herpes simplex encephalitis has been reported to be very sensitive for the diagnosis,3 8 but as we have shown, great care must be taken in interpreting a negative result if there is strong clinical suspicion. We have no adequate explanation as to why the PCR was negative on three occasions including the sample before any treatment in this definite case.…”

Section: Discussionmentioning

confidence: 90%

Imaging and laboratory investigation in herpes simplex encephalitis

Coren

Buchdahl²,

Cowan³

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

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A 14 day old baby presented with signs of an acute encephalitis. Clinically, herpes simplex encephalitis (HSE) was suspected. Early MRI and EEG were normal and there was rapid clinical improvement. A negative polymerase chain reaction (PCR) result on the initial CSF sample seemed to make HSE most unlikely. This diagnosis was subsequently proved after demonstration of specific antibody production using immunoelectrophoresis of the CSF. The child had extensive damage to brain tissue. The need for sequential analysis of CSF in making or refuting this diagnosis is illustrated. (J Neurol Neurosurg Psychiatry 1999;67:243-245)

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Section: Discussionmentioning

confidence: 90%

Imaging and laboratory investigation in herpes simplex encephalitis

Coren

Buchdahl²,

Cowan³

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

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Chronic meningitis due to herpes simplex virus in an immunocompetent host

Chin

Ross

Taylor

et al. 1996

Eur. J. Clin. Microbiol. Infect. Dis.

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Herpes simplex virus (HSV) typically causes mucocutaneous disease, encephalitis, and acute men ingitis. There have been no previous reports of chronic meningitis due to this virus. A case of chronic meningitis due to herpes simplex virus type 2 (HSV-2) in a previously healthy 35-year-old woman whose predominant symptoms were headache and meningism without fever is described. Analysis of cerebrospinal fluid (CSF) revealed a lymphocytic pleocytosis, elevated protein, and hypoglycorrhachia. The diagnosis of herpes simplex meningitis was supported by the detection of HSV-2 DNA in CSF by polymerase chain reaction and by intrathecal production of HSV-specific antibody. The patient recovered after treatment with intravenous acyclovir and glucocorticoids.

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Cerebrospinal fluid.

Thompson¹

1995

Journal of Neurology, Neurosurgery & Psychiatry

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PCR in herpes simplex virus infections of the central nervous system

Cited by 3 publications

References 54 publications

Imaging and laboratory investigation in herpes simplex encephalitis

Imaging and laboratory investigation in herpes simplex encephalitis

Chronic meningitis due to herpes simplex virus in an immunocompetent host

Cerebrospinal fluid.

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