PD-1-expressing B cells suppress CD4+ and CD8+ T cells via PD-1/PD-L1-dependent pathway

Wang, Xufu; Wang, Guoqiang; Wang, Zenghua; Liu, Bin; Han, Na; Li, Jiao; Lu, Chunyang; Liu, Xinfeng; Zhang, Qin; Yang, Qingbo; Wang, Guo‐Ming

doi:10.1016/j.molimm.2019.02.009

Cited by 96 publications

(87 citation statements)

References 20 publications

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“…Moreover, the modulating effect of IL-10 on B cells was already demonstrated in earlier studies 72,73 , whether IL-10 influences directly the expression of cell inhibitory molecules e.g. PD-L1, FasL, to increase cell contact-dependent suppressive activity of B cells 41,43,[74][75][76] , is currently unknown but suggested by previous publications showing an IL-10-inducible PD-L1 expression on monocytes 77,78 . Another possibility is that IL-10 is able to directly affect T cell suppression, but only in the presence of signaling from cell inhibitory molecules; however, this needs further investigation.…”

Section: Discussionmentioning

confidence: 83%

“…7d). In addition to IL-10, Bregs impair T cell function via surface proteins such as PD-L1 40,41 and FasL 42,43 . Therefore, we determined, whether Bregs generated by TLR9 activation show enhanced expression of these proteins.…”

Section: Regulatory B Cells Can Inhibit or Suppress Inflammation Medimentioning

confidence: 99%

“…Besides IL-10 secretion, the immunosuppressive capacity or checkpoint activity of regulatory B cells has also been associated with the production of IL-35 38 , TGF-ß 39 and inhibitory costimulatory molecules e.g. PD-L1 40,41 and FasL 42,43 .…”

Section: Introductionmentioning

confidence: 99%

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TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines

Honke

Lowin

Opgenoorth

et al. 2020

Preprint

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The sympathetic nervous system (SNS) contributes to immune balance by promoting antiinflammatory B cells. However, whether B cells possess a self-regulating mechanism by which they modulate regulatory B cell (Breg) function is not well understood. In this study, we investigated the ability of B cells to synthesize catecholamines upon stimulation with different B cell activators. We found, that expression of the enzymes required to generate catecholamines, is upregulated by TLR9. TLR-9-specific expression of tyrosine hydroxylase (TH) correlated with upregulation of adrenergic receptors, enhanced IL-10 production, and with an overexpression of the co-inhibitory ligands PD-L1 and FasL. Moreover, concomitant stimulation of ß1-3-adrenergic receptors together with a BCR/TLR9 stimulus enhances the anti-inflammatory potential of Bregs to suppress CD4 T cells, a crucial population in the pathogenesis of autoimmune diseases, like rheumatoid arthritis. In conclusion, our data show that B cells possess autonomous mechanisms to modulate their regulatory function. These findings help to better understand the function of Bregs in autoimmune diseases and the interplay of sympathetic nervous system and B cell function.3 Introduction:

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Section: Discussionmentioning

confidence: 83%

Section: Regulatory B Cells Can Inhibit or Suppress Inflammation Medimentioning

confidence: 99%

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TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines

Honke

Lowin

Opgenoorth

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Whether ectopic germinal centers are 290 present in the brain with cryptococcal meningitis, which has a prominent component in 291 the brain parenchyma, as were identified with neurosyphilis (40) was increased on activated B cells, particularly CD27+ and tissue-like memory cells, as 307 reported by others (43,45). Indeed, microbial antigens, modeled by toll-like receptor-9 to its effects on T cells, PD-1 on B cells can inhibit B cell activation, suppress B cell 310 proliferation and impair B cell inflammatory cytokine responses (12,13,45,47). 311…”

Section: Pd-1 Plasmablasts/plasma Cells Expression Subjects With Thementioning

confidence: 81%

“…including plasma cells, modulate the activity of other immune cells in the local 120 environment (4), as may B cells expressing surface immunomodulatory molecules such 121 as PD-1 (12,13). 122…”

Section: Introduction 101mentioning

confidence: 99%

B cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis

Okurut

Meya

Bwanga

et al. 2019

Preprint

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Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment

Shi,

Cheng,

Jiang

et al. 2024

Advanced Science

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B cells are crucial component of humoral immunity, and their role in the tumor immune microenvironment (TME) has garnered significant attention in recent years. These cells hold great potential and application prospects in the field of tumor immunotherapy. Research has demonstrated that the TME can remodel various B cell functions, including proliferation, differentiation, antigen presentation, and antibody production, thereby invalidating the anti‐tumor effects of B cells. Concurrently, numerous immune checkpoints (ICs) on the surface of B cells are upregulated. Aberrant B‐cell IC signals not only impair the function of B cells themselves, but also modulate the tumor‐killing effects of other immune cells, ultimately fostering an immunosuppressive TME and facilitating tumor immune escape. Blocking ICs on B cells is beneficial for reversing the immunosuppressive TME and restoring anti‐tumor immune responses. In this paper, the intricate connection between B‐cell ICs and the TME is delved into, emphasizing the critical role of targeting B‐cell ICs in anti‐tumor immunity, which may provide valuable insights for the future development of tumor immunotherapy based on B cells.

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PD-1-expressing B cells suppress CD4+ and CD8+ T cells via PD-1/PD-L1-dependent pathway

Cited by 96 publications

References 20 publications

TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines

TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines

B cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis

Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment

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