Pd31-06 the Effect of Naftopidil 75mg for the Double-J Stent Related Discomfort: Multicenter, Randomized, Double-Blind, Placebo Controlled Study.

Abstract

Chi-Square, Fischer's exact, student's t or Mann Whitney U tests as appropriate.RESULTS: 151 participants were enrolled and randomized into the study. 31 participants did not return their 24 hour VAS and were excluded. There was no difference in age, sex, stent duration, largest stone size, stone location, stone number, or initial VAS between groups (all >0.05). 3 of 120 (2.5%) of participants had severe pain (VAS >70) at follow-up. Opiate use did not differ between groups (12.5% vs 7.8%, p¼0.39), but patients who used opiates (n ¼ 12) had higher 24 hour VAS scores that those who did not (mean 32.1 mm in those using opiates, 4.9 mm in those not using opiates p<0.001) and a greater decrease in VAS (p¼ 0.004). 24 hour VAS scores were significantly lower in the treatment group (median VAS, 3.3 mm versus 0 mm, p¼0.04), but there was no difference between groups in the frequency of a change in VAS >20 (p¼0.20) or of patients with severe pain (p¼1.0).CONCLUSIONS: Though there was a statistically significant difference in 24 hour VAS between groups, it does not appear to be clinically relevant. Significant pain after ureteral stent removal appears to be a rare phenomenon not requiring prophylactic pain medication.

Treatment of Ureteral Stent-Related Symptoms

“…Finally, as secondary outcome, we focused on the IPSS and QoL score from Shalaby et al [25], Tehranchi et al [19], and Oh et al [26]. Our results confirmed the ones obtained from the USSQ analysis.…”