Objective. To survey the application of PDCA (plan, do, check, and action) process management in day operation ward and the influence of nursing quality and safety. Methods. The routine nursing management was carried out in our hospital from March 2019 to March 2020, which was set as the control group (
N
=
20
), and the PDCA process management was implemented from March 2020 to March 2021 as the research group (
N
=
20
). Twenty nurses and patients were selected as subjects in two periods of time. The nursing quality, the score of individual quality control examination in clinical department, the nursing quality of operating room, the incidence of adverse events and nursing errors, the number of problems existing in the quality management of nursing documents, and the score of nursing satisfaction were accessed. Results. In the comparison of nursing quality, the nursing safety, specialty quality, and nursing norms of the study group were higher compared to the control (
P
<
0.05
). In terms of the scores of individual quality control examination in clinical departments, the scores of ward management, rescue, therapeutic articles, drug management, first-level nursing, nursing documents, and head nurses in the study group were greater compared to the control (
P
<
0.05
). In terms of the operating room nursing quality score, the instrument management, instrument preparation, nurses’ cooperation skills, disinfection and isolation quality, and the total score of the study group were above the control (
P
<
0.05
). In terms of the incidence of operative adverse events and nursing errors, the incidence of nosocomial infection, iatrogenic injury, information check error, equipment failure, violation of operation regulations, ECG monitoring error, infusion operation error, and medication error in the study group was lower compared to the control (
P
<
0.05
). According to the comparison of the number of problems existing in the quality management of nursing documents, the number of problems in temperature sheet, medical order, evaluation sheet, nursing record, and other nursing documents in the study group was lower than the control (
P
<
0.05
). The scores of nursing communication, professional technology, nursing service attitude, nursing environment, and knowledge education in the study group were higher in contrast to the control (
P
<
0.05
). Conclusion. The application of PDCA management can effectively enhance the nursing quality and safety of the day operation ward, further facilitate the quality of hospital nursing work, and improve patient satisfaction, which exert great potential, and application value in the management of day ward in the future.