This research is carried out in Traditional medicine a company, at Jakarta. Which is one of the pharmaceutical companies in Indonesia. This company has conducted research from the year 2000 to find "active ingredients of medicines" from natural ingredients native to Indonesia. This herbal medicine production process produces animal protein extract product derived from cork fish that are rich in albumin. However, when the evaporation process the protein content produced is below the set standards, so that the impact on protein extraction result is less than the maximum. The evaporation process aims to get extracts that are highly concentrated by efforts to reduce the solvent in the product so that it only leaves the active ingredients alone. By evaporating the product in a vessel accompanied by a vacuum so that the activity level of protein content contained in the product can be increased. To prevent the decrease in activity of protein levels, resulting from evaporation. Effort were made to increase the activity of protein levels in the evaporation process using the Plan-Do-Check-Action method, the results obtained from the improvement process with the PDCA pattern this was found to be improved by increasing protein levels by 73.43%, with these results expected to optimize the efficacy and quality of the medicinal product for consumption