PDMS membrane-based flexible bi-layer microfluidic device for blood oxygenation

Narendran, G.; Hoque, S. Z.; Satpathi, Niladri Sekhar; Nampoothiri, Krishnadas Narayanan; Sen, A. K.

doi:10.1088/1361-6439/ac7ea6

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…The width and interelectrode spacing are kept fixed at 20 μm which gives a resonant frequency of 49.98 MHz. To avoid direct electrical connections between the ice and the IDTs, thin polydimethylsiloxane (PDMS) film of 20 μm thickness is fabricated and placed over the IDTs and the lead wires. With such thin PDMS layers, the attenuation of SAW power due to the presence of a PDMS layer is found to be negligible .…”

Section: Methodsmentioning

confidence: 99%

“…With such thin PDMS layers, the attenuation of SAW power due to the presence of a PDMS layer is found to be negligible. 39 The thin layer of PDMS is applied by spin coating a mixture of liquid PDMS with a base-to-curing agent ratio of 1:10 over a glass slide at 4000 rpm for 10 s using a spin coater 38 after which it is peeled off and placed over the IDTs.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Deicing of Sessile Droplets Using Surface Acoustic Waves

et al. 2023

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Deicing has significant relevance in various applications such as transportation, energy production, and telecommunication. The use of surface acoustic waves (SAWs) is an attractive option for deicing as it offers several advantages such as localized heating, in situ control, low power, and system integration for highly efficient deicing. Here, we report an understanding of the dynamics of deicing of microlitre volume water droplets (1 to 30 μL) exposed to low power (0.3 W) SAW actuation using an interdigitated electrode on a piezoelectric (LiNbO 3 ) substrate. We study the time variation of the volume of liquid water from the onset of SAW actuation to complete deicing, which takes 2.5 to 35 s depending on the droplet volume. The deicing phenomenon is attributed to acoustothermal heating which is found to be greatly influenced by the loss of ice adhesion with the substrate and the acoustic streaming within the liquid water. Acoustothermal heating inside the droplet is characterized by the temperature distribution inside the droplet using infrared thermography, and acoustic streaming is observed using dye-based optical microscopy. A rapid enhancement in deicing is observed upon the detachment of ice from the substrate and the onset of acoustic streaming, marked by a sudden increase in the liquid water volume, droplet temperature, and heat transfer coefficient. The deicing time is found to increase linearly with droplet volume as observed from experiments and further verified using a theoretical model. Our study provides an improved understanding of the recently introduced SAW-based deicing technique that may open up the avenue for a suitable alternative to standard deicing protocols.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Deicing of Sessile Droplets Using Surface Acoustic Waves

et al. 2023

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“…Hollow fiber membranes have been used as an oxygenator and are usually obtained via a phase inversion process [ 191 , 192 ]. The commonly used polymers for hollow fiber membranes are hydrophobic polymers, such as polymethylpentene (PMP), polypropylene (PP), PDMS, polysulfone (PSf), polyethersulfone (PES), polyethylene (PE) and polyvinylidene fluoride (PVDF) [ 26 , 192 , 193 , 194 , 195 , 196 , 197 , 198 ]. Wang et al [ 194 ] reported the production of poly (4-methyl-1-pentene)/polypropylene (PMP/PP) thin film composite (TFC) with a PVA/PSS coating was anchored on the membrane surface via crosslinking and PDA binding for membrane oxygenator application.…”

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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“…In severe liver dysfunction, toxins might build up in the blood and lead to hepatic encephalopathy, potentially leading to multi-organ failure [ 8 ]. This can be addressed by artificial devices similar to dialysis [ 9 ] and blood oxygenator [ 10 ] systems. These devices work by recapitulating liver functions within a synthetic liver that is capable of adsorption and filtering as an artificial liver support device [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Demonstration of Compact Polymer Mass Transfer Device Manufactured by Additive Manufacturing with Hydrogel Integration to Bio-Mimic the Liver Functions

et al. 2023

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In this paper, we designed and demonstrated a stimuli-responsive hydrogel that mimics the mass diffusion function of the liver. We have controlled the release mechanism using temperature and pH variations. Additive manufacturing technology was used to fabricate the device with nylon (PA-12), using selective laser sintering (SLS). The device has two compartment sections: the lower section handles the thermal management, and feeds temperature-regulated water into the mass transfer section of the upper compartment. The upper chamber has a two-layered serpentine concentric tube; the inner tube carries the temperature-regulated water to the hydrogel using the given pores. Here, the hydrogel is present in order to facilitate the release of the loaded methylene blue (MB) into the fluid. By adjusting the fluid’s pH, flow rate, and temperature, the deswelling properties of the hydrogel were examined. The weight of the hydrogel was maximum at 10 mL/min and decreased by 25.29% to 10.12 g for the flow rate of 50 mL/min. The cumulative MB release at 30 °C increased to 47% for the lower flow rate of 10 mL/min, and the cumulative release at 40 °C climbed to 55%, which is 44.7% more than at 30 °C. The MB release rates considerably increased when the pH dropped from 12 to 8, showing that the lower pH had a major impact on the release of MB from the hydrogel. Only 19% of the MB was released at pH 12 after 50 min, and after that, the release rate remained nearly constant. At higher fluid temperatures, the hydrogels lost approximately 80% of their water in just 20 min, compared to a loss of 50% of their water at room temperature. The outcomes of this study may contribute to further developments in artificial organ design.

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PDMS membrane-based flexible bi-layer microfluidic device for blood oxygenation

Cited by 8 publications

References 49 publications

Deicing of Sessile Droplets Using Surface Acoustic Waves

Deicing of Sessile Droplets Using Surface Acoustic Waves

Polymeric Membranes for Biomedical Applications

Experimental Demonstration of Compact Polymer Mass Transfer Device Manufactured by Additive Manufacturing with Hydrogel Integration to Bio-Mimic the Liver Functions

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