Peak trabecular vertebral density: A comparison of adolescent and adult females

Gilsanz, Vicente; Gibbens, D T; Carlson, Michael; Boechat, M. Ines; Cann, Christopher E.; Schulz, Eloy

doi:10.1007/bf02555144

Cited by 207 publications

(83 citation statements)

References 13 publications

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“…(11,26) We found FN values to occur substantially earlier (3 years after PHV) than the other sites, but LS peaks were similar to the TH, with TB occurring 2 years later.…”

Section: Discussionmentioning

confidence: 62%

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Baxter-Jones

Faulkner

Forwood

et al. 2011

Journal of Bone and Mineral Research

541

385

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Bone area (BA) and bone mineral content (BMC) were measured from childhood to young adulthood at the total body (TB), lumbar spine (LS), total hip (TH), and femoral neck (FN). BA and BMC values were expressed as a percentage of young-adult values to determine if and when values reached a plateau. Data were aligned on biological ages [years from peak height velocity (PHV)] to control for maturity. TB BA increased significantly from À4 to þ4 years from PHV, with TB BMC reaching a plateau, on average, 2 years later at þ6 years from PHV (equates to 18 and 20 years of age in girls and boys, respectively). LS BA increased significantly from À4 years from PHV to þ3 years from PHV, whereas LS BMC increased until þ4 from PHV. FN BA increased between À4 and þ1 years from PHV, with FN BMC reaching a plateau, on average, 1 year later at þ2 years from PHV. In the circumpubertal years (À2 to þ2 years from PHV): 39% of the young-adult BMC was accrued at the TB in both males and females; 43% and 46% was accrued in males and females at the LS and TH, respectively; 33% (males and females) was accrued at the FN. In summary, we provide strong evidence that BA plateaus 1 to 2 years earlier than BMC. Depending on the skeletal site, peak bone mass occurs by the end of the second or early in the third decade of life. The data substantiate the importance of the circumpubertal years for accruing bone mineral. ß

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“…(11,26) We found FN values to occur substantially earlier (3 years after PHV) than the other sites, but LS peaks were similar to the TH, with TB occurring 2 years later.…”

Section: Discussionmentioning

confidence: 62%

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Baxter-Jones

Faulkner

Forwood

et al. 2011

Journal of Bone and Mineral Research

541

385

View full text Add to dashboard Cite

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“…Other, and sometimes the same, growth and closure of epiphyseal growth zones at hormones and growth factors can stimulate both about age 19 years. [155] The cumulative result of proliferation and differentiation and hypertrophy of different time courses of longitudinal growth, cells. Examples of such dual agents in the bone are [157] includes DNA replication (S phase), preparation for mitosis (G2 phase) and mitosis (M phase).…”

Section: Messengers That Influence Bonementioning

confidence: 99%

Physical Activity in the Prevention and Amelioration of Osteoporosis in Women

2005

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“…This significant increase stops at the end of the third decade [4][5][6]. Peak bone mass is an important risk factor for the development of osteoporosis in later life [7]. By knowing physiological variations in bone mass accrual during childhood and adolescence we could predict who is at greater risk for osteoporotic fractures and other bone metabolism disorders [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Many factors affect bone growth, BMC and BMD, such as birth weight, maternal ultraviolet B exposure during pregnancy [10], and behavioural factors like physical activity [9,11], diet [7], vitamin D [12] and calcium intake [13,14], alcohol consumption [7] and carbonated soft drinks [15]. Hormonal balance and its fine interplay are also very important and necessary for normal bone development, primarily sex hormones, growth hormone (GH) [16] and insulin-like growth factors (IGFs) [17].…”

Section: Introductionmentioning

confidence: 99%

Interaction Between Clinical and Laboratorys Indicators and Genetic Polymorphysms of the Calcaneal Bone Mineral Density in Children Starting Puberty. Is this a Time for Intervention?

Miškić¹,

Raguž²

2015

J Osteopor Phys Act

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Volume 3 • Isse 2 • 1000130length before menarche, suggesting that during puberty, circulating IGF-1 promotes bone periosteal apposition and mass accrual [9].Genetic factors also affect the speed of maturation and growth. Adult height is considered to be a highly heritable and polygenetic trait. Bone mineral density is also highly heritable trait, with as much as 60-80% of variance attributable to genetic factors [21][22][23]. In recent years many studies investigated genetic background of BMD and osteoporosis revealing different genetic markers across the chromosomes [24-27].Previous results indicated the association between genetic markers for IGF-1 gene, gene for estrogen receptor alpha, gene for androgen receptor, aromatase gene [28], vitamin D receptor gene [18], gene for colagen-1 [19] with BMD, bone geometry and osteoporosis. Majority of the research included adults, only recently there is an increased interest in researching genetic determinants of bone metabolism in children [19,20].There are few approaches in measurement of bone mineral density (BMD), but the easiest and ethically more acceptable approach in children is the use of quantitative ultrasound (QUS), a quick, noninvasive and inexpensive method to measure bone strength [21][22][23].

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Peak trabecular vertebral density: A comparison of adolescent and adult females

Cited by 207 publications

References 13 publications

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Physical Activity in the Prevention and Amelioration of Osteoporosis in Women

Interaction Between Clinical and Laboratorys Indicators and Genetic Polymorphysms of the Calcaneal Bone Mineral Density in Children Starting Puberty. Is this a Time for Intervention?

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