Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair

Zhou, Chuchao; Luo, Chao; Liu, Shaokai; Jiang, Shangxuan; Liu, Xin; Li, Jialun; Zhang, Xinyue; Wu, Xiaoyan; Sun, Jiaming; Wang, Zhenxing

doi:10.1016/j.mtbio.2022.100307

Cited by 16 publications

(10 citation statements)

References 64 publications

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“…The osteogenesis promoted by the GO-based collagen scaffold could be boosted by adding inorganics, such as strontium, to the mixture [ 89 ], activating a protein complex responsible for bone-cell proliferation and differentiation. GO-based collagen composites can also be coupled with hydroxyapatite, as reported by Zhou et al [ 90 ]. The authors crafted a multi-layer mineralized composite able to upregulate genes involved in osteogenesis, providing a comfortable microenvironment for hosting the cells of bone tissues.…”

Section: Carbon-containing Biopolymer Composites For Biomedical Appli...mentioning

confidence: 95%

A Short Review on Nanostructured Carbon Containing Biopolymer Derived Composites for Tissue Engineering Applications

2023

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The development of new scaffolds and materials for tissue engineering is a wide and open realm of material science. Among solutions, the use of biopolymers represents a particularly interesting area of study due to their great chemical complexity that enables creation of specific molecular architectures. However, biopolymers do not exhibit the properties required for direct application in tissue repair—such as mechanical and electrical properties—but they do show very attractive chemical functionalities which are difficult to produce through in vitro synthesis. The combination of biopolymers with nanostructured carbon fillers could represent a robust solution to enhance composite properties, producing composites with new and unique features, particularly relating to electronic conduction. In this paper, we provide a review of the field of carbonaceous nanostructure-containing biopolymer composites, limiting our investigation to tissue-engineering applications, and providing a complete overview of the recent and most outstanding achievements.

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Section: Carbon-containing Biopolymer Composites For Biomedical Appli...mentioning

confidence: 95%

A Short Review on Nanostructured Carbon Containing Biopolymer Derived Composites for Tissue Engineering Applications

2023

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“…To further validate the therapeutic efficacy of GO/Cu-functionalized hydrogel scaffolds in bone reconstruction, a modified calvarial bone defect model in rats was established according to previously published procedures [6,27,35]. The animal experiments reported herein were evaluated and approved by the Laboratory Animal Welfare and Ethical Committee (IACUC) of Central South University (Nos.…”

Section: In Vivo Bone Reconstruction Efficacy 271 Establishment Of a ...mentioning

confidence: 99%

“…To achieve satisfactory therapeutic outcomes, autologous, allogenic and artificial bone grafts have been extensively applied in current clinical scenarios [5]. Nevertheless, the clinical promotion and application of these grafts are always restricted due to donor site injury, limited availability, potential infectious disease transmission, immunological rejection and substantial economic burden [5][6][7]. As an alternative approach to satisfy the ever-increasing demand for bone repair, bone tissue engineering (BTE) has been a research hotspot for the last decade that has shown improvements in material science, processing techniques and in-depth understanding of bone healing mechanisms [5,8].…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide/copper nanosheet-integrated hydrogel platform as a bioactive and biocompatible scaffold to accelerate calvarial defect restoration

Yang,

Zhou,

et al. 2023

Preprint

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Background The treatment of craniofacial bone defects caused by trauma, tumors, and infectious and degenerative diseases is a significant issue in current clinical practice. Following the rapid development of bone tissue engineering (BTE) in the last decade, bioactive scaffolds coupled with multifunctional properties are in high demand with regard to effective therapy for bone defects. Methods In this study, motivated by the versatile biological functions of nanomaterials and synthetic hydrogels, copper nanoparticle (CuNP)-decorated graphene oxide (GO) nanosheets (GO/Cu) were combined with methacrylated gelatin (GelMA)-based organic-inorganic hybrids to construct porous bone scaffolds that mimic the extracellular matrix (ECM) of bone tissues by photocrosslinking. The material characterizations, in vitro cytocompatibility and osteogenesis of the biohybrid hydrogel scaffolds were investigated, and two different animal models were established to further confirm the in vivo neovascularization, macrophage recruitment, biocompatibility, biosafety and bone regenerative potential. Results It found that GO/Cu-functionalized GelMA/β-TCP hydrogel scaffolds exhibited evidently promoted osteogenic activities and excellent cytocompatibility, with favorable surface characteristics and sustainable release of Cu2+. Additionally, improved neovascularization, macrophage recruitment and tissue integration were found in mice implanted with the bioactive hydrogels. More importantly, the observations of microCT reconstruction and histological analysis in a calvarial bone defect model in rats treated with GO/Cu-incorporated hydrogel scaffolds, demonstrated significantly accelerated bone healing. Conclusions Taken together, this BTE-based bone repair strategy provides a promising and feasible method for constructing multifunctional GO/Cu nanocomposite- incorporated biohybrid hydrogel scaffolds with facilitated osteogenesis, angiogenesis and immunoregulation in one system, thereby demonstrating the great application potential for correcting craniofacial bone defects in future clinical scenarios.

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“…Collagen is capable of inducing osteogenic differentiation for bone repairing by providing a suitable microenvironment [148]. Currently, the focus of bone defect recovery is centered on promoting osteogenic differentiation via the use of mineralized collagen gels [149]. Enlighted by the pearl assembly procedure, the multi-structure of the gel with the addition of graphene oxide and hydroxyapatite was established.…”

Section: Bone and Cartilage Repairingmentioning

confidence: 99%

Structure, extraction, processing, and applications of collagen as an ideal component for biomaterials - a review

et al. 2023

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Collagen with a multi-hierarchical architecture exhibits powerful biological performance, thus being developed in biomedical applications as a processing building block. The isolated collagen after extraction from biological tissues can be processed into various forms such as fibrils, scaffolds, membranes, microspheres, hydrogels, and sponges for further use in specific applications. This review briefly discusses the multi-hierarchical structure, powerful biological performances, extraction, and processing approaches of collagen as a natural biomaterial. The processing of collagen including dissolution, self-assembly, cross-linking, and electrospinning, is discussed to show more feasibility for specific applications of collagen composite biomaterials. Further emphasis is directed towards the biomedical applications of drug and gene delivery, as well as tissue repair involving bone, cartilage, vascular, and corneal, along with wound healing. Additionally, there is a focus on the development of flexible sensors and electronic skins (e-skins). Furthermore, the potential challenges and perspectives for the development of collagen-based biomaterials are proposed. In short, collagen-based biomaterials are expected to facilitate sustainable development and the next generation of advanced biomaterial applications. Graphical Abstract

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Pearl-inspired graphene oxide-collagen microgel with multi-layer mineralization through microarray chips for bone defect repair

Cited by 16 publications

References 64 publications

A Short Review on Nanostructured Carbon Containing Biopolymer Derived Composites for Tissue Engineering Applications

A Short Review on Nanostructured Carbon Containing Biopolymer Derived Composites for Tissue Engineering Applications

Graphene oxide/copper nanosheet-integrated hydrogel platform as a bioactive and biocompatible scaffold to accelerate calvarial defect restoration

Structure, extraction, processing, and applications of collagen as an ideal component for biomaterials - a review

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