Pearls and pitfalls of imaging metastatic disease from pancreatic adenocarcinoma: a systematic review

Zaheer, Atif; Wadhwa, Vibhor; Oh, Joseph; Fishman, Elliot K.

doi:10.1016/j.clinimag.2015.04.017

Cited by 12 publications

(4 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imaging modalities such as Computed Tomography (CT) and Magnetic Resonance (MR) are routinely performed during the follow-up of oncologic patients [6][7][8][9][10]. In this setting CT and MR may play a crucial role in the early identification of PM, but their part in the management of PM has been evaluated only on small series of patients [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Previous studies ( 32 , 33 ) have suggested that clinical symptoms of PM-SCLC and PDAC were similar including weight loss, jaundice, pain, dyspepsia and nausea, etc. The clinical symptoms of PM-SCLC were not prominent except in a few cases, while most PDAC is accompanied by clinical symptoms except for early PDAC ( 30 , 32 , 34 , 35 ). In our study, the absence of clinical symptoms was discriminating variable to differentiate PPM from PDAC, there were significant differences in clinical symptoms between the two groups (P < 0.001).…”

Section: Discussionmentioning

confidence: 90%

A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers

Yang

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveTo investigate clinical characteristics, radiological features and biomarkers of pancreatic metastases of small cell lung carcinoma (PM-SCLC), and establish a convenient nomogram diagnostic predictive model to differentiate PM-SCLC from pancreatic ductal adenocarcinomas (PDAC) preoperatively.MethodsA total of 299 patients with meeting the criteria (PM-SCLC n=93; PDAC n=206) from January 2016 to March 2022 were retrospectively analyzed, including 249 patients from hospital 1 (training/internal validation cohort) and 50 patients from hospital 2 (external validation cohort). We searched for meaningful clinical characteristics, radiological features and biomarkers and determined the predictors through multivariable logistic regression analysis. Three models: clinical model, CT imaging model, and combined model, were developed for the diagnosis and prediction of PM-SCLC. Nomogram was constructed based on independent predictors. The receiver operating curve was undertaken to estimate the discrimination.ResultsSix independent predictors for PM-SCLC diagnosis in multivariate logistic regression analysis, including clinical symptoms, CA199, tumor size, parenchymal atrophy, vascular involvement and enhancement type. The nomogram diagnostic predictive model based on these six independent predictors showed the best performance, achieved the AUCs of the training cohort (n = 174), internal validation cohort (n = 75) and external validation cohort (n = 50) were 0.950 (95%CI, 0.917-0.976), 0.928 (95%CI, 0.873-0.971) and 0.976 (95%CI, 0.944-1.00) respectively. The model achieved 94.50% sensitivity, 83.20% specificity, 86.80% accuracy in the training cohort and 100.00% sensitivity, 80.40% specificity, 86.70% accuracy in the internal validation cohort and 100.00% sensitivity, 88.90% specificity, 87.50% accuracy in the external validation cohort.ConclusionWe proposed a noninvasive and convenient nomogram diagnostic predictive model based on clinical characteristics, radiological features and biomarkers to preoperatively differentiate PM-SCLC from PDAC.

show abstract

“…The accurate staging of PAC is essential, due to the metastatic nature and course of treatment of the disease (111). Therefore, imaging techniques are essential in differentiating metastatic disease from other entities (56).…”

Section: Discussionmentioning

confidence: 99%

A pancreatic adenocarcinoma mimicking hepatoid carcinoma of uncertain histogenesis: A case report and literature review

Iliesiu,

Toma,

Ciongariu

et al. 2023

Oncol Lett

View full text Add to dashboard Cite

In rare cases, metastatic adenocarcinomas of different origin may exhibit the features of hepatoid carcinoma (HC), a rare malignant epithelial tumor, most commonly occurring in the ovaries and stomach, as well as in the pancreas and biliary ducts. A case of a 72-year-old female patient who developed a highly aggressive, poorly differentiated pancreatic ductal adenocarcinoma with peritoneal carcinomatosis, demonstrating hepatoid differentiation upon conventional hematoxylin and eosin staining is reported in the present study. The patient presented with severe abdominal pain, and the radiological investigations performed revealed ovarian and hepatic tumor masses and peritoneal lesions, which were surgically removed. The gross examination of the peritoneum and omentum revealed multiple solid, firm, grey-white nodules, diffusely infiltrating the adipose tissue. The microscopic examination revealed a malignant epithelial proliferation, composed of polygonal cells with abundant eosinophilic cytoplasm and irregular, pleomorphic nuclei. Certain cells presented with intracytoplasmic mucus inclusions, raising suspicion of a HC with an uncertain histogenesis. Immunohistochemical staining was performed, and the tumor cells were found to be positive for cytokeratin (CK)7, CK18 and mucin 5AC, whereas negative staining for CK20, caudal-type homeobox transcription factor 2, α-fetoprotein, paired box gene 8, GATA-binding protein 3 and Wilms tumor 1 were documented. Thus, the diagnosis of metastatic pancreatic adenocarcinoma was established. The main aim of the present study was to provide further knowledge concerning poorly differentiated metastatic adenocarcinoma resembling HC, emphasizing the histopathological and immunohistochemical features of these malignant lesions and raising awareness of the diagnostic difficulties that may arise, as well as the importance of the use immunohistochemistry in differentiating carcinomas of uncertain histogenesis.

show abstract

Pearls and pitfalls of imaging metastatic disease from pancreatic adenocarcinoma: a systematic review

Cited by 12 publications

References 65 publications

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers

A pancreatic adenocarcinoma mimicking hepatoid carcinoma of uncertain histogenesis: A case report and literature review

Contact Info

Product

Resources

About