Pectin

Rolin, Claus

doi:10.1016/b978-0-08-092654-4.50014-0

Cited by 80 publications

(44 citation statements)

References 104 publications

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“…As a result pectin has increasingly gained acceptance as the carrier polymer for sustained release and site specific delivery dosage forms, such as beads, pellets, tablets, and films [26,27]. Upon addition, pectin forms rigid gels with calcium, which cross-links the galacturonic acid chains [28]. Several researchers have successfully incorporated protein or peptide into calcium pectinate beads for a colonic delivery system [29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

2016

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Folic acid is used for preventing and treating multiple diseases and disorders, administered in the form of oral supplements. The present research work was aimed to study the influence of two non-ionic surfactants Poloxamer and Tween 80 (Polysorbate 80) on pectin submicrospheres formulations. Typical natural polymer pectin was used to encapsulate folic acid by cross linking method. The resultant submicrospheres contributed to improve the aqueous solubility to enhance the bioavailability of folic acid. During investigation, it was observed that pectin polymers influenced kinetics of the rate of reaction more intensively than the surfactants. The physical phenomenon caused the change in their size, shape and chemistry of pectin polymers transforming into submicrospheres in aqueous condition. The characteristic differences of submicrospheres were assessed by scanning electron microscopy, differential scanning calorimetry and Fouriertransform infrared spectroscopy. The average diameters of the submicrospheres ranged between 250 and 500 nm. The encapsulation efficiency of submicrospheres ranged between 80 and 96 %. The characteristic swelling behavior of lyophilized submicrospheres was influenced by the ratio of pectin polymers and folic acid used in the formulations. The submicrospheres systems exhibited controlled release of folic acid due to the pH-dependent solubility of pectin polymers in aqueous medium. The submicrospheres showed good haemocompatibility suggesting them to be promising candidates for oral delivery.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

2016

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“…A investigação do processo de gelificação em sistemas HMP-sacarose tem mostrado que o tempo de gelificação apresenta uma dependência complexa com a temperatura [27,28] . As interações hidrofóbicas, eletrostáticas e ligações de hidrogê-nio contribuem para a formação e estabilização da rede do gel e essas interações são afetadas pela temperatura.…”

Section: Resultsunclassified

Influência de fatores estruturais no processo de gelificação de pectinas de alto grau de metoxilação

Brandão

Andrade

1999

Polímeros

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RESUMO: Duas amostras de pectina de alto grau de metoxilação, amostras A e B, foram purificadas, levando-se em conta os teores em grupos metoxílicos. Sua caracterização estrutural foi realizada através de dosagem de açúcares neutros com auxílio de cromatografia gasosa, GLC, e determinação do grau de metoxilação por técnicas de cromatografia líquida de alta resolução, HPLC. A amostra A apresentou teores mais elevados em açúcares neutros totais e grau de metoxilação mais alto. As viscosidades intrínsecas, [eta] = 3,68 dL/g e [eta] = 3,56 dL/g foram determinadas a pH 7,0 para as amostras A e B, respectivamente. A pH 3,0, valores menores foram obtidos. A gelificação das amostras foi investigada, em função da concentração e da temperatura, medindo-se os módulos de armazenamento, G', e de perda, G", em função do tempo. A pH 3,0 a pectina A apresentou taxas de gelificação mais elevadas, tanto em função da concentração como da temperatura.

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“…This is because at acidic pH, alginate microspheres shrink due to the tightening of gel meshwork, whereas at pH 6.8 alginate errodes and releases the contents in a sustained manner (14). Algino-pectinate microspheres (F5 to F8) were more efficient in sustaining the drug release compared to alginate microspheres (F1-F4) because pectin could form a rigid coat with calcium ions (15), thus forming a calcium-pectinate gel matrix. Free carboxyl groups in the HM pectin molecule are distributed block-wise; therefore the gelation of this pectin is possible because of the »egg-box« structure, resulting from chelation of calcium ions in electronegative cavities formed by the carboxyl residues and hydroxyl groups (16).…”

Section: Bioadhesive Property Of Microspheresmentioning

confidence: 99%

Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis

Chakraborty¹,

Khandai²,

Sharma³

et al. 2010

Acta Pharmaceutica

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Aceclofenac (AC) is a phenyl acetic acid derivative [2-(2',6'-dichlorophenyl)amino] phenylacetoxyacetic acid], a novel NSAID indicated for the symptomatic treatment of pain and inflammation (1). The short biological half-life (about 4 h) and high frequency of dosing make aceclofenac an ideal candidate for sustained release. The bioadhesive microspheres of aceclofenac would prolong the residence time at the absorption site to facilitate intimate contact with the absorption surface and thereby improve and enhance bioavailability and increase patient compliance. Natural hydrophilic polymers like alginate and pectin are widely used in numerous biomedical applications for their bioadhesion properties. Alginic acid and pectin are natural polysaccharides that are widely Ionotropic gelation was used to entrap aceclofenac into algino-pectinate bioadhesive microspheres as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Microspheres were investigated in vitro for possible sustained drug release and their use in vivo as a gastroprotective system for aceclofenac. Polymer concentration and polymer/drug ratio were analyzed for their influence on microsphere properties. The microspheres exhibited good bioadhesive property and showed high drug entrapment efficiency. Drug release profiles exhibited faster release of aceclofenac from alginate microspheres whereas algino-pectinate microspheres showed prolonged release. Dunnet's multiple comparison analysis suggested a significant difference in percent inhibition of paw edema when the optimized formulation was compared to pure drug. It was concluded that the algino-pectinate bioadhesive formulations exhibit promising properties of a sustained release form for aceclofenac and that they provide distinct tissue protection in the stomach.

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Pectin

Cited by 80 publications

References 104 publications

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Influência de fatores estruturais no processo de gelificação de pectinas de alto grau de metoxilação

Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis

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