Pectin beads loaded with chitosan–iron microspheres for specific colonic adsorption of ciprofloxacin

Reynaud, Franceline; Tsapis, Nicolas; Guterres, Sílvia Stanisçuaski; Pohlmann, Adriana Raffin; Fattal, Elias

doi:10.1016/j.jddst.2015.07.014

Cited by 16 publications

(4 citation statements)

References 26 publications

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“…However, a low drug loading efficiency, a short half-time, and the lack of targeting limited the application of pectin-based drug delivery systems. − Commonly, the reduction of blood component interactions will induce the activation of the complement system, resulting in a decrease in the blood clearance rate of the drug carrier, namely, the stealth effect . Polyethylene glycol (PEG) is a nonionic hydrophilic polymer with stealth behavior, which reduces the aggregation tendency of nanoparticles by spatial stability and affects the pharmacokinetic performance of drugs or carriers. , PEG shielding or PEG administration could prolong the blood circulation time and increase the possibility of the drug reaching the site of action …”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Folic Acid-Targeted Pectin-Multi-Arm Polyethylene Glycol Nanoparticles for Tumor Intracellular Chemotherapy

et al. 2021

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Ursolic acid is widely used as an effective anticancer drug for the treatment of various cancers. However, its poor water solubility, short circulation time in vivo, and lack of targeting have made it a burden for clinical applications. We report a self-assembled folatemodified pectin nanoparticle for loading ursolic acid (HCPT@F-Pt-PU NPs) and embed the anticancer drug hydroxycamptothecin to achieve synergistic treatment with ursolic acid. In addition, the galactose residue of the pectin molecule can be recognized by the asialoglycoprotein receptor on the surface of the liver cancer cell, promoting the rapid penetration and release of HCPT@F-Pt-PU NPs intracellularly. In particular, the introduction of multiarm polyethylene glycol can improve the uniformity (106 nm) and concealment of the nanoparticles and avoid the early release of the drug or the toxicity to normal cells. HCPT@F-Pt-PU NPs have a high drug loading (7.27 wt %) and embedding efficiency (19.84 wt %) and continuous circulation up to 80 h, leading to more apoptosis (91.

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Section: Introductionmentioning

confidence: 99%

Self-Assembled Folic Acid-Targeted Pectin-Multi-Arm Polyethylene Glycol Nanoparticles for Tumor Intracellular Chemotherapy

et al. 2021

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“…The pharmacokinetic parameters of the proposed drug system have been determined in vivo on rats [22]. Other studies reported pectin microparticles for targeted drug delivery in the colon of 5-fluorouracil [68,69], metronidazole [70][71][72], vancomycin [23], indomethacin [73,74], ciprofloxacin [75], curcumin [76,77], methotrexate [21], sulfasalazine [78], etc.…”

Section: Figure 4 Pectin-based Microparticles As Drug Delivery Systemsmentioning

confidence: 99%

Utilization of pectin as a polysaccharide microcarrier for drug delivery

Paolina Lukova

2023

World J. Bio. Pharm. Health Sci.

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Pectin is a polysaccharide of natural origin, which has been widely exploited in the food and pharmaceutical industry due to its biodegradable and biocompatible nature. It is commonly used as an efficient texturizer and stabilizer in different food products due to its high stability and also as a pharmaceutical excipient in various drug formulations due to its valuable characteristics. The utilization of pectin as a drug carrier for achieving controlled drug release in pharmaceutical dosage forms has been extensively researched recently. Pectin has the potential for targeted drug delivery due to its degradation by colonic microorganisms, making it a popular subject of investigation for biomedical applications. The developed in recent years pectin microparticle systems have several advantages over classical pectin gel formulations. These advantages include higher drug loading efficiency, reduced burst drug release, and the ability to better control the drug release and limit the polymer swelling. This review outlines the recent developments of pectin as a microcarrier in the production of drug delivery systems, which include the properties of the polysaccharide material essential for microparticle production, specific formulation methods with their key technological parameters, influencing the final microparticle product and potential applications of the proposed pectin microsized formulations.

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“…Research has been carried out using the ionotropic gelation method with pectin microspheres to encapsulate violet crystal, ciprofloxacin, polyphenols, and β-carotenes of Taraxacum officinale [59][60][61]. All of this research has applications for human health.…”

Section: Ionotropic Gelationmentioning

confidence: 99%

Pectin Microspheres: Synthesis Methods, Properties, and Their Multidisciplinary Applications

2022

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There is great contemporary interest in using cleaner technologies through green chemistry and utilizing biopolymers as raw material. Pectin is found on plant cell walls, and it is commonly extracted from fruit shells, mostly apples or citrus fruits. Pectin has applications in many areas of commercial relevance; for this reason, it is possible to find available information about novel methods to transform pectin and pursuing enhanced features, with the structuring of biopolymer microspheres being highly cited to enhance its activity. The structuring of polymers is a technique that has been growing in recent decades, due to its potential for diverse applications in various fields of science and technology. Several techniques are used for the synthesis of microspheres, such as ionotropic gelation, extrusion, aerosol drying, or emulsions, with the latter being the most commonly used method based on its reproducibility and simplicity. The most cited applications are in drug delivery, especially for the treatment of colon diseases and digestive-tract-related issues. In the industrial field, it is used for protecting encapsulated compounds; moreover, the environmental applications mainly include the bioremediation of toxic substances. However, there are still many possibilities for expanding the use of this biopolymer in the environmental field.

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Pectin beads loaded with chitosan–iron microspheres for specific colonic adsorption of ciprofloxacin

Cited by 16 publications

References 26 publications

Self-Assembled Folic Acid-Targeted Pectin-Multi-Arm Polyethylene Glycol Nanoparticles for Tumor Intracellular Chemotherapy

Self-Assembled Folic Acid-Targeted Pectin-Multi-Arm Polyethylene Glycol Nanoparticles for Tumor Intracellular Chemotherapy

Utilization of pectin as a polysaccharide microcarrier for drug delivery

Pectin Microspheres: Synthesis Methods, Properties, and Their Multidisciplinary Applications

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