Pectin-like acidic polysaccharide from Panax ginseng with selective antiadhesive activity against pathogenic bacteria

A novel phenol-bound pectic polysaccharide fromDecalepis hamiltoniiwith multi-step ulcer preventive activity

“…The results are in accordance with the observation made by Lee et al [36] , where inhibition of H pylori growth by pectic polysaccharide was reported. However the mechanism still needs to be established.…”

The inhibitory effect of ginseng pectin on L-929 cell migration

“…Ginseng polysaccharides are mainly composed of neutral polysaccharides (starch-like glucans) and acidic substances (ginseng pectin) (Ovodov and Solov'eva, 1966). Ginseng pectin has a wider range of pharmacological activities than ginseng neutral polysaccharides, including inhibiting gastric lesions (Kiyoyaha et al, 1994), inhibiting adhesion of bacteria to host cells (Lee et al, 2006(Lee et al, , 2009, protecting animals from the lethal effects of ionizing radiation (Song et al, 2003;Kim et al, 2007), reducing blood glucose levels in normal and hyperglycemic mice (Konno et al, 1984;Suzuki and Hikino, 1989), inhibiting tumor growth and metastasis (Kim et al, 1990;Yun et al, 1993;Shin et al, 2004), and modulating the immune system (Song et al, 2003;Han et al, 2005;Du et al, 2008). However, less is known of the mechanisms by which ginseng pectin exerts these effects.…”

Inhibition of Pathogen Adhesion to Host Cells by Polysaccharides fromPanax ginseng

“…Acidic polysaccharides from the roots of P. ginseng were prepared as described previously. 11) Final gel filtration chromatography revealed a major peak of PG-F2 and a minor peak of PG-HMW at higher molecular weight.…”

“…8) Since PG-F2 from P. ginseng first demonstrated a marked inhibitory effect against the adhesion of Helicobacter pylori to erythrocytes, it has been found to be effective against P. gingivalis, A. actinomycetemcomitans, P. acnes, and S. aureus by hemagglutination assay. [9][10][11][12] In the present study, we examined the antiadhesive role of acidic polysaccharides of P. ginseng against oral and skin bacterial adhesion to human and mouse cell lines.…”

“…12) At least 25 mM (about 5 mg/ml) glucuronic acid was necessary to inhibit P. gingivalis adherence to host cells significantly. 25) Importantly, ginseng polysaccharides show no inhibitory effects against L. acidophilus, B. bifidum, E. coli, or S. epidermidis, 11) suggesting that they have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on beneficial bacteria. Our results might provide a novel clue to the health benefits of P. ginseng.…”