Pecularities of lesions in viral and mycoplasma infections of the respiratory tract

Zinserling, A. V.

doi:10.1007/bf00543159

Cited by 52 publications

(15 citation statements)

References 5 publications

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“…Other findings seen in the current study included groundglass attenuation, centrilobular nodules, and centrilobular branching structures present in 97%, 61%, and 34% of patients with bacterial pneumonia, respectively. Mycoplasmal pneumonia is characterized by an infiltration of inflammatory cells predominantly in the bronchiolar and peribronchiolar regions [15,22,23]. The characteristic high-resolution CT findings consist of centrilobular branching structures and nodules, bronchial wall thickening, air-space consolidation, and ground-glass attenuation with lobular distribution [1].…”

Section: Discussionmentioning

confidence: 99%

Acute Parenchymal Lung Disease in Immunocompetent Patients

Tomiyama

Müller

Johkoh

et al. 2000

American Journal of Roentgenology

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Section: Discussionmentioning

confidence: 99%

Acute Parenchymal Lung Disease in Immunocompetent Patients

Tomiyama

Müller

Johkoh

et al. 2000

American Journal of Roentgenology

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“…Histopathologically, the target of M. pneumoniae is regarded to be the ciliated cells of the respiratory tract, resulting in acute cellular bronchiolitis with edematous and ulcerative changes of the bronchial/bronchiolar walls and peribronvascular interstitial infiltrates of lymphocytes, plasma cells, and macrophages [12][13][14]. A mononuclear cell infiltrate occurs to a variable degree in adjacent parenchyma surrounding involved bronchioles.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma pneumoniae pneumonia: CT features in 16 patients

2005

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The objective of this study was to assess the computed tomography (CT) features of Mycoplasma pneumoniae pneumonia. We retrospectively reviewed CT findings of 16 patients (M:F = 9:7, age range 1-74 years, median 9 years) with serologically proven Mycoplasma pneumoniae pneumonia and with chest CT scan available. Two distinctive patterns of CT features of M. pneumoniae pneumonia were noted between the paediatric (age < 18 years) and the adult (age > or = 18 years) groups. The pediatric group (n=11) showed lobar or segmental consolidation (100%) with frequent pleural effusion (82%) and regional lymphadenopathy (82%) and mild volume decrease of the involved lobe (73%), while four of the five adult patients showed diffuse and/or multifocal, centrilobular or peribronchovascular areas of ground-glass attenuation (80%) with a lobular distribution, and frequent thickening of interlobular septa (60%) and the bronchial walls (40%) were also detected at high-resolution CT. The CT finding of a lobar or segmental consolidation with a parapneumonic effusion seen in our children with M. pneumoniae pneumonia was similar to that of bacterial lobar pneumonia. In contrast, the CT findings noted in our adult patients consisted of a mixture of a bacterial bronchopneumonia pattern and a viral interstitial pneumonia pattern.

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“…When pneumonia is predominant, a moderate hyperplasia of alveolar epithelia is observed and fluid containing some macrophages, erythrocytes, and leukocytes accumulates (117). The mechanisms of cell damage include both direct destruction by the virus and effects of the immune response (70).…”

Section: Proteins and Their Antigenic Structurementioning

confidence: 99%

Biology of parainfluenza viruses

Vainionpää

Hyypiä

1994

Clin Microbiol Rev

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Parainfluenza virus types 1 to 4 (PIV1 to PIV4) are important human pathogens that cause upper and lower respiratory tract infections, especially in infants and children. PIV1, PIV2, and PIV3 are second only to respiratory syncytial virus as a cause of croup in young children. Although some clinical symptoms are typical of PIVs, etiologic diagnosis always requires detection of infectious virus, viral components, or an antibody response. PIVs are typical paramyxoviruses, causing a syncytial cytopathic effect in cell cultures; virus growth can be confirmed either by hemadsorption or by using immunological reagents. Currently, PIV is most often diagnosed by demonstrating viral antigens in clinical specimens by rapid and highly sensitive immunoassays. More recently, PCR has been used for the detection of PIVs. Serological diagnosis is made by detecting a rising titer of immunoglobulin G or by demonstrating immunoglobulin M antibodies. PIVs infect species other than humans, and animal models are used to study the pathogenesis of PIV infections and to test candidate vaccines. Accumulating knowledge on the molecular structure and mechanisms of replication of PIVs has accelerated research on prevention and treatment. Several strategies for vaccine development, such as the use of live attenuated, inactivated, recombinant, and subunit vaccines, have been investigated, and it may become possible to prevent PIV infections in the near future.

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Pecularities of lesions in viral and mycoplasma infections of the respiratory tract

Cited by 52 publications

References 5 publications

Acute Parenchymal Lung Disease in Immunocompetent Patients

Acute Parenchymal Lung Disease in Immunocompetent Patients

Mycoplasma pneumoniae pneumonia: CT features in 16 patients

Biology of parainfluenza viruses

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